Prokaryotic Diacylglycerol Kinase and Undecaprenol Kinase [PDF]
Annual Review of Biophysics, 2012 Prokaryotic diacylglycerol kinase (DAGK) and undecaprenol kinase (UDPK) are the lone members of a family of multispan membrane enzymes that are very small, lack relationships to any other family of proteins—including water soluble kinases—and exhibit an unusual structure and active site architecture.
Charles R. Sanders, Wade D. Van Horn
openaire +3 more sources
Zeitschrift für Kristallographie - New Crystal Structures, 2019 C23H23N3O6, monoclinic, P21/c (no. 14), a = 11.235(6) Å, b = 11.251(7) Å, c = 17.814(10) Å, β = 98.872(12)°, V = 2225(2) Å3, Z = 4, Rgt(F) = 0.0581, wRref(F2) = 0.1590, T = 296(2) K.
Tan Hong-bo, Hu Chun-sheng
doaj +1 more source
Characterization of a Plastoglobule-Localized SOUL4 Heme-Binding Protein in Arabidopsis thaliana
Frontiers in Plant Science, 2020 Heme plays an active role in primary plant metabolic pathways as well as in stress signaling. In this study, we characterized the predicted heme-binding protein SOUL4.
Venkatasalam Shanmugabalaji +2 more
doaj +1 more source
Targeting kinases with anilinopyrimidines: Discovery of N-phenyl-N'-[4-(pyrimidin-4-ylamino)phenyl]urea derivatives as selective inhibitors of class III receptor tyrosine kinase subfamily [PDF]
, 2015 Kinase inhibitors are attractive drugs/drug candidates for the treatment of cancer. The most recent literature has highlighted the importance of multi target kinase inhibitors, although a correct balance between specificity and non-specificity is ...
Chilin, Adriana +5 more
core +1 more source
Biomolecules, 2019 The identification and clarification of the mechanisms of action of drugs used against leishmaniasis may improve their administration regimens and prevent the development of resistant strains.
Andrés Vacas +7 more
doaj +1 more source
Oncogenic RET Kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans [PDF]
, 2014 To decipher the molecular basis for RET kinase activation and oncogenic deregulation, we defined the temporal sequence of RET autophosphorylation by label-free quantitative mass spectrometry.
Airaksinen +40 more
core +1 more source
Unraveling the Function of Lemur Tyrosine Kinase 2 Network
Frontiers in Pharmacology, 2019 Lemur Tyrosine Kinase 2 (LMTK2) is a recently cloned transmembrane protein, actually a serine/threonine kinase named after the Madagascar primate lemur due to the long intracellular C-terminal tail.
Daniel F. Cruz +3 more
doaj +1 more source
Positional information readout in $Ca^{2+}$ signaling [PDF]
Phys. Rev. Lett. 123, 058102 (2019), 2017 Living cells respond to spatial signals. Signal transmission to the cell interior often involves the release of second messengers like $Ca^{2+}$ . They will eventually trigger a physiological response by activating kinases that in turn activate target proteins through phosphorylation. Here, we investigate theoretically how positional information can be
arxiv +1 more source
Phosphoinositide-dependent protein kinase-1 (PDK1)-independent activation of the protein kinase C substrate, protein kinase D [PDF]
, 2007 Phosphoinoisitide dependent kinase l (PDK1) is proposed to phosphorylate a key threonine residue within the catalytic domain of the protein kinase C (PKC) superfamily that controls the stability and catalytic competence of these kinases.
April P. Kelly +29 more
core +3 more sources
A synthetic inhibitor of the mitogen-activated protein kinase cascade.
Proceedings of the National Academy of Sciences of the United States of America, 1995 Treatment of cells with a variety of growth factors triggers a phosphorylation cascade that leads to activation of mitogen-activated protein kinases (MAPKs, also called extracellular signal-regulated kinases, or ERKs).
D. T. Dudley +4 more
semanticscholar +1 more source