Results 151 to 160 of about 8,462,139 (217)

Mechanisms by Which Kinesin-5 Motors Perform Their Multiple Intracellular Functions. [PDF]

Int J Mol Sci, 2021
Pandey H, Popov M, Goldstein-Levitin A, Gheber L.   +3 more
europepmc   +1 more source

Effect of Kinesin-5 Tail Domain on Motor Dynamics for Antiparallel Microtubule Sliding. [PDF]

Int J Mol Sci, 2021
Liu Y, Wang Y, Wang P, Xie P.
europepmc   +1 more source

Flexible microtubule anchoring modulates the bi-directional motility of the kinesin-5 Cin8. [PDF]

Cell Mol Life Sci, 2021
Pandey H, Singh SK, Sadan M, Popov M, Singh M, Davidov G, Inagaki S, Al-Bassam J, Zarivach R, Rosenfeld SS, Gheber L.   +10 more
europepmc   +1 more source

“Mitotic” kinesin-5 is a dynamic brake for axonal growth

During neuronal development, neurons undergo significant microtubule reorganization to shape axons and dendrites, establishing the framework for efficient wiring of the nervous system. Previous studies from our laboratory demonstrated the key role of kinesin-1 in driving microtubule-microtubule sliding, which provides the mechanical ...
Wen Lu, Brad S. Lee, Helen Xue Ying Deng, Margot Lakonishok, Enrique Martin-Blanco, Vladimir I. Gelfand   +5 more
openaire   +2 more sources

Kinesin-8 and Dis1/TOG collaborate to limit spindle elongation from prophase to anaphase A for proper chromosome segregation in fission yeast

, 2020
High-fidelity chromosome segregation relies on proper microtubule regulation. Kinesin-8 has been shown to destabilise microtubules to reduce metaphase spindle length and chromosome movements in multiple species.
Corinne Pinder (8319063), Yuzy Matsuo (334029), Takashi Toda (102488), Sebastian P Maurer (8319066)   +3 more
core  

Allosteric inhibition of kinesin-5 modulates its processive directional motility

, 2006
Small-molecule inhibitors of kinesin-5 (refs. 1-3), a protein essential for eukaryotic cell division(4), represent alternatives to antimitotic agents that target tubulin(5,6).
Schmidt, C., Kapoor, Tarun M., Peterman, E.J.G., Lukas C Kapitein, Benjamin H Kwok, Kwok, B. H., Kapitein, Lukas C., Kim, J., Christoph F Schmidt, Kapitein, L.C., Kapoor, T. M., Kwok, Benjamin H., Peterman, Erwin J. G., Jeffrey H Kim, Erwin J G Peterman, Kim, Jeffrey H., Schmidt, Christoph, Tarun M Kapoor   +17 more
core   +1 more source

Increased <i>KIF11</i>/<i>kinesin-5</i> expression offsets Alzheimer Aβ-mediated toxicity and cognitive dysfunction. [PDF]

iScience, 2022
Lucero EM, Freund RK, Smith A, Johnson NR, Dooling B, Sullivan E, Prikhodko O, Ahmed MM, Bennett DA, Hohman TJ, Dell'Acqua ML, Chial HJ, Potter H.   +12 more
europepmc   +1 more source

The Arabidopsis thaliana Kinesin-5 AtKRP125b Is a Processive, Microtubule-Sliding Motor Protein with Putative Plant-Specific Functions. [PDF]

Int J Mol Sci, 2021
Strauß T, Schattner S, Hoth S, Walter WJ.   +3 more
europepmc   +1 more source

Mechanism of Microtubule Stabilization by Kinesin-5 [PDF]

Biophysical Journal, 2018
Geng-Yuan Chen, Ana B. Asenjo, Hernando J. Sosa, William O. Hancock   +3 more
openaire   +1 more source

Kinetic and mechanistic basis of the nonprocessive Kinesin-3 motor NcKin3

, 2006
Kinesin-3 motors have been shown to transport cellular cargo along microtubules and to function according to mechanisms that differ from the conventional hand-over-hand mechanism.
Woehlke, G., Leier, Sven, Adio, S., Bloemink, Marieke J., Woehlke, Gunther, Geeves, M., Bloemink, M., Leier, S., Geeves, Michael A., Hartel, M., Hartel, Michaela, Adio, Sarah   +11 more
core   +1 more source