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Bidirectional motility of the fission yeast kinesin-5, Cut7
Biochemical and Biophysical Research Communications, 2014Kinesin-5 is a homotetrameric motor with its motor domain at the N-terminus. Kinesin-5 crosslinks microtubules and functions in separating spindle poles during mitosis. In this study, the motile properties of Cut7, fission yeast kinesin-5, were examined for the first time.
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Role of kinesin-5 in growth cone behavior
The growth cone at the tip of the axon is essential for guiding the axon during development to its appropriate target. Growth cones can be divided into a microtubule-rich central (C-) domain, an actin-rich peripheral (P-) domain and the transition (T-) zone between them.Vidya C. Nadar, Peter W. Baas
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An “In Schizo” Evaluation System to Screen for Human Kinesin-5 Inhibitors
Kinesin-5 motor proteins are essential for mitotic spindle formation and maintenance, ensuring accurate chromosome segregation. Human kinesin-5 is highly expressed in various cancer cells but not in nonproliferative tissues; therefore, it is expected to be an attractive target for cancer chemotherapy, with fewer adverse side effects.Fara Difka, Afdilla +2 more
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Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments
Nature Communications, 2020Verena Henrichs +2 more
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Kinesin-1 activity recorded in living cells with a precipitating dye
Nature Communications, 2021Simona Angerani +2 more
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A Kinesin-14 Motor Activates Neocentromeres to Promote Meiotic Drive in Maize
Cell, 2018R Kelly Dawe +2 more
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