Results 181 to 190 of about 8,462,139 (217)

Cryo-EM structure of the Ustilago maydis kinesin-5 motor domain bound to microtubules.

J Struct Biol, 2019
von Loeffelholz O, Moores CA.
europepmc   +1 more source

Cryo-EM Structure (4.5-Å) of Yeast Kinesin-5-Microtubule Complex Reveals a Distinct Binding Footprint and Mechanism of Drug Resistance.

J Mol Biol, 2019
von Loeffelholz O, Peña A, Drummond DR, Cross R, Moores CA.   +4 more
europepmc   +1 more source

Correction: Sensory cilia: How molecular motors can shape ciliary tip organization and diversity. [PDF]

J Cell Biol
Durand B.
europepmc   +1 more source

Nuclei on the move: LINC complex-dependent and -independent mechanisms of nuclear migration in development. [PDF]

Nucleus
Gümüşderelioğlu S, Gant Luxton GW, Starr DA.   +2 more
europepmc   +1 more source

Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis [PDF]

Journal of Cell Biology, 2003
We have investigated the function of mitotic kinesin-like protein (MKlp) 2, a kinesin localized to the central spindle, and demonstrate that its depletion results in a failure of cleavage furrow ingression and cytokinesis, and disrupts localization of ...
Christian Preißinger, Erich A Nigg, Thomas U Mayer   +2 more
exaly   +2 more sources

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Characterization of the motility of monomeric kinesin-5/Cin8

Biochemical and Biophysical Research Communications, 2021
Cin8, the Saccharomyces cerevisiae kinesin-5, has an essential role in mitosis. In in vitro motility assays, tetrameric and dimeric Cin8 constructs showed bidirectional motility in response to ionic strength or Cin8 motor density. However, whether property-switching directionality is present in a monomeric form of Cin8 is unknown.
Masahiko Yamagishi, Yohei Maruyama, Mitsuhiro Sugawa, Junichiro Yajima   +3 more
openaire   +2 more sources

Kinesin-5 Regulation and Function in Mitosis

Trends in Cell Biology, 2019
Chromosome segregation during cell division requires a bipolar mitotic spindle. Therefore, how the spindle is formed, maintained, and functions is of fundamental importance for all eukaryotic cells. Members of the evolutionarily conserved kinesin-5 family of motor proteins have been shown to play an essential role in spindle formation by generating ...
Barbara J, Mann, Patricia, Wadsworth
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A common ATP-dependent stepping model for kinesin-5 and kinesin-1: Mechanism of bi-directionality of kinesin-5

Biophysical Chemistry, 2021
Kinesin-5 and kinesin-1 proteins are two families of kinesin superfamily molecular motors that can move processively on microtubules powered by ATP hydrolysis. Kinesin-1 is a unidirectional motor. By contrast, some yeast kinesin-5 motors are bidirectional and the directionality can be switched by changing the experimental conditions. Here, on the basis
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Kinesin‐5 is not essential for mitotic spindle elongation in Dictyostelium

Cell Motility, 2008
AbstractThe proper assembly and operation of the mitotic spindle is essential to ensure the accurate segregation of chromosomes and to position the cytokinetic furrow during cell division in eukaryotes. Not only are dynamic microtubules required but also the concerted actions of multiple motor proteins are necessary to effect spindle pole separation ...
Irina, Tikhonenko, Dilip K, Nag, Nora, Martin, Michael P, Koonce   +3 more
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Walking, hopping, diffusing and braking modes of kinesin-5

Biochemical Society Transactions, 2009
It is clear that the main cellular mission of the molecular motor kinesin-5 (known as Eg5 in vertebrates) is to cross-link antiparallel microtubules and to slide them apart, thus playing a critical role during bipolar spindle formation. Nonetheless, important questions about the cell biological and biophysical mechanisms of Eg5 remain unanswered.
Kuniyoshi, Kaseda, Andrew D, McAinsh, Robert A, Cross   +2 more
openaire   +2 more sources