Results 131 to 140 of about 83,587 (297)

Kinesin 1 regulates cilia length through an interaction with the Bardet-Biedl syndrome related protein CCDC28B

Scientific Reports, 2018
Bardet-Biedl syndrome (BBS) is a ciliopathy characterized by retinal degeneration, obesity, polydactyly, renal disease and mental retardation. CCDC28B is a BBS-associated protein that we have previously shown plays a role in cilia length regulation ...
Rossina Novas, Magdalena Cardenas-Rodriguez, Paola Lepanto, Matías Fabregat, Magela Rodao, María Inés Fariello, Mauricio Ramos, Camila Davison, Gabriela Casanova, Lucía Alfaya, Federico Lecumberry, Gualberto González-Sapienza, Florencia Irigoín, Jose L. Badano   +13 more
doaj   +1 more source

Imaging malaria parasites across scales and time

Journal of Microscopy, EarlyView.
Abstract The idea that disease is caused at the cellular level is so fundamental to us that we might forget the critical role microscopy played in generating and developing this insight. Visually identifying diseased or infected cells lays the foundation for any effort to curb human pathology.
Julien Guizetti
wiley   +1 more source

A model for hand-over-hand motion of molecular motors

, 2008
A simple flashing ratchet model in two dimensions is proposed to simulate the hand-over-hand motion of two head molecular motors like kinesin. Extensive Langevin simulations of the model are performed.
E. Helfand, F. Falo, H. S. Greensidea, J. Howard, J. J. Mazo, J. Munárriz, P. Nelson   +6 more
core   +1 more source

Molecular insights into electroreceptor ribbon synapses from differential gene expression in sturgeon lateral line organs

Journal of Anatomy, EarlyView.
The expression of various genes involved in synapse development, stability and/or function was studied in developing mechanosensory neuromasts and electrosensory ampullary organs in sterlet sturgeon. Most were shared, including Slc17a8, Slc1a3 and Nrxn3, but Cbln18 was neuromast‐restricted and Tulp1 was ampullary organ‐restricted.
Alexander S. Campbell, Martin Minařík, David Buckley, Tanmay Anand, David Gela, Martin Pšenička, Clare V. H. Baker   +6 more
wiley   +1 more source

RNAi reveals a unique set of kinesins mediating chloroplast motility in the giant cytoplasm of Bryopsis (Ulvophyceae), a coenocytic green alga

Journal of Phycology, EarlyView.
Abstract RNA interference (RNAi) is a powerful tool for protein knockdown and is widely used in model animals and plants. Here, we implemented RNAi in Bryopsis, a green feather alga that develops a coenocytic thallus >10 cm in length without cytokinesis.
Harumi A. Ogawa, Kanta K. Ochiai, Maki Shirae‐Kurabayashi, Gohta Goshima   +3 more
wiley   +1 more source

Starch synthesis in Brachypodium distachyon endosperm occurs in dynamic, connected amyloplast compartments

New Phytologist, EarlyView.
Summary The morphology of starch granules is a major determinant of the functional and nutritional properties of starch and is highly variable among cereal species. Much of this morphological variation stems from differences in the spatial and temporal patterns of starch granule initiation in amyloplasts during grain development.
Lara Esch, Qi Yang Ngai, Sergio G. Lopez, J. Elaine Barclay, Inmaculada Hernández‐Pinzón, Matthew J. Moscou, David Seung   +6 more
wiley   +1 more source

Unconventional Secretion of Angiogenic Sonic Hedgehog–Containing Extra‐Large Extracellular Vesicles is Driven by PI3K–Rab18‐GDP Signalling [PDF]

J Extracell Biol
Human mesenchymal stem cells conditionally secrete sonic hedgehog (SHH)‐containing extra‐large extracellular vesicles (XLEVs) upon PI3K activation, which enriches the GDP‐bound form of Rab18. Rab18‐GDP drives perinuclear maturation and polarized vertical release of SHH‐XLEVs via Hsp90α‐ and nSMase2‐dependent mechanisms.
Wang S, Imai R, Kaneko Y, Tanaka Y.
europepmc   +2 more sources

A Single‐Base Mutation in TaWAK3‐B Reduces Plant Height via Cytoskeleton in Bread Wheat

Plant Biotechnology Journal, EarlyView.
ABSTRACT Introduction of Reduced height (Rht) genes into modern wheat cultivars has resulted in ‘Green Revolution’ that skyrocketed wheat grain yields worldwide since the 1960s. These ‘Green Revolution’ cultivars show shorter plant height, but higher lodging resistance and harvest index.
Naijiao Wang, Ruolin Bian, Dejie Du, Yunjie Liu, Yiao Ma, Zihao Jiang, Zhaoju Li, Yan Zhou, Xiangyu Zhang, Zhaoheng Zhang, Beilu Cao, Xiongtao Li, Zhaoyan Chen, Jie Liu, Qixin Sun, Zhongfu Ni, Lingling Chai   +16 more
wiley   +1 more source

Microfluidic Device to Measure Collective Force Dynamics of Kinesin Motor Proteins [PDF]

, 2018
Joseph M. Cleary, William O. Hancock
openalex   +1 more source

Harnessing blue light photobiomodulation for cancer therapy: Evidence from a systematic review

Photochemistry and Photobiology, EarlyView.
Conventional treatments for various types of cancer are often associated with tumor recurrence and aggressiveness. Photobiomodulation with blue light (BL; 450–470 nm) emerges as a promising alternative with antitumor effects. This systematic review, with 37 in vitro and in vivo studies from 2002 to 2024, revealed that BL reduces cell viability ...
Bárbara Evelyn Santos de Lima, Rebeca Barros Nascimento, Ana Paula Mariano Santos Ginez, Maria Stella Moreira, Rebeca Boltes Cecatto, Rodrigo Labat Marcos, Maria Fernanda Setúbal Destro Rodrigues   +6 more
wiley   +1 more source