Results 111 to 120 of about 51,301 (248)
A "holistic" kinesin phylogeny reveals new kinesin families and predicts protein functions [PDF]
, 2016 Kinesin superfamily proteins are ubiquitous to all eukaryotes and essential for several key cellular processes. With the establishment of genome sequence data for a substantial number of eukaryotes, it is now possible for the first time to analyze the ...
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RNF13 regulates the endolysosomal pathway through interaction with the small GTPase Arl8B
The FEBS Journal, EarlyView.The E3 ubiquitin ligase RNF13 functions as a regulatory scaffold, organizing Arl8B‐dependent complexes and tuning downstream signaling that controls endolysosomal organization and trafficking. In this model, wild‐type RNF13 associates with Arl8B on endolysosomes, whereas Arl8B (E22D/F55A) or RNF13 (L244A) variants weaken complex assembly, potentially ...
Audrey M. Sénécal +4 more
wiley +1 more source
PLoS Genetics, 2012 Hereditary spastic paraplegias (HSPs) comprise a group of genetically heterogeneous neurodegenerative disorders characterized by spastic weakness of the lower extremities.
Petra Füger +12 more
doaj +1 more source
The structural switch of nucleotide-free kinesin
, 2017 International audienceKinesin-1 is an ATP-dependent motor protein that moves towards microtubules (+)-ends. Whereas structures of isolated ADP-kinesin and of complexes with tubulin of apo-kinesin and of ATP-like-kinesin are available, structural data on ...
Gigant, Benoît +5 more
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Energetic dysregulations in psychotic disorders: Targets for new therapeutics
The FEBS Journal, EarlyView.The present review synthesizes literature documenting aberrant energy production and use, specifically related to mitochondrial and redox dysregulation, in psychotic disorders. Findings from different levels of investigation—genetic, cellular, and in vivo imaging—converge on aberrant energy metabolism as a hallmark of psychotic disorders.
Jacey Anderson +10 more
wiley +1 more source
A moving kinesin motor protein
, 2016 Shows two heads of the kinesin dimer work in a coordinated manner to move processively along the track. The coiled coil (gray) extends towards the top and leads up to the kinesin cargo. Each catalytic core (blue) is bound to a tubulin heterodimer (green,
Vale, Ronald D., Milligan, Ronald A.
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IFT cargo and motors associate sequentially with IFT trains to enter cilia of C. elegans
Nature CommunicationsIntraflagellar transport (IFT) orchestrates entry of proteins into primary cilia. At the ciliary base, assembled IFT trains, driven by kinesin-2 motors, can transport cargo proteins into the cilium, across the crowded transition zone. How trains assemble
Aniruddha Mitra +2 more
doaj +1 more source
Cryo-EM reveals the structural basis of microtubule depolymerization by kinesin-13s
Nature Communications, 2018 Kinesin-13s are microtubule depolymerases that lack motile activity. Here the authors present the cryo-EM structures of kinesin-13 microtubule complexes in different nucleotide bound states, which reveal how ATP hydrolysis is linked to conformational ...
Matthieu P.M.H. Benoit +2 more
doaj +1 more source
The role of casein in supporting the operation of surface bound kinesin
Journal of Biological Engineering, 2008 Microtubules and associated motor proteins such as kinesin are envisioned for applications such as bioseparation and molecular sorting to powering hybrid synthetic mechanical devices.
Hancock William O +2 more
doaj +1 more source
Natural variation in GmSOP5 regulates seed oil and protein content during soybean domestication
Journal of Integrative Plant Biology, EarlyView.The domestication‐related gene Seed Oil and Protein 5 regulates seed oil and protein content without a yield penalty, providing insight into early soybean domestication and identifying a genetic pathway that balances the trade‐off between seed quality and yield in soybean.
Yu Tian +18 more
wiley +1 more source