Results 151 to 160 of about 94,650 (353)

IFT cargo and motors associate sequentially with IFT trains to enter cilia of C. elegans

Nature Communications
Intraflagellar transport (IFT) orchestrates entry of proteins into primary cilia. At the ciliary base, assembled IFT trains, driven by kinesin-2 motors, can transport cargo proteins into the cilium, across the crowded transition zone. How trains assemble
Aniruddha Mitra, Elizaveta Loseva, Erwin J. G. Peterman   +2 more
doaj   +1 more source

Connecting neurodevelopment to neurodegeneration: a spotlight on the role of kinesin superfamily protein 2A (KIF2A)

Neural Regeneration Research
Microtubules play a central role in cytoskeletal changes during neuronal development and maintenance. Microtubule dynamics is essential to polarity and shape transitions underlying neural cell division, differentiation, motility, and maturation.
Nuria Ruiz-Reig, Janne Hakanen, Fadel Tissir   +2 more
doaj   +1 more source

High-resolution structures of kinesin on microtubules provide a basis for nucleotide-gated force-generation

eLife, 2014
Microtubule-based transport by the kinesin motors, powered by ATP hydrolysis, is essential for a wide range of vital processes in eukaryotes. We obtained insight into this process by developing atomic models for no-nucleotide and ATP states of the ...
Zhiguo Shang, Kaifeng Zhou, Chen Xu, Roseann Csencsits, Jared C Cochran, Charles V Sindelar   +5 more
doaj   +1 more source

Single kinesin molecules crossbridge microtubules in vitro. [PDF]

, 1993
S.B. Andrews, P.E. Gallant, Richard D. Leapman, Bruce J. Schnapp, Thomas S. Reese   +4 more
openalex   +1 more source

Intracellular cargo transport by kinesin-3 motors

Biochemistry (Moscow), 2017
Intracellular transport along microtubules enables cellular cargoes to efficiently reach the extremities of large, eukaryotic cells. While it would take more than 200 years for a small vesicle to diffuse from the cell body to the growing tip of a one ...
N. Siddiqui, A. Straube
semanticscholar   +1 more source

Exploration of Biomarkers of Food Intake in a Caribbean Hispanic Population

Molecular Nutrition &Food Research, EarlyView.
Validated BFIs show significant associations with food intake in an observational setting, and those associations were often modulated by non‐dietary factors. The identification of genotype‐BFI associations implies that the utility of a BFI could depend on common genetic differences.
Laurence D. Parnell, Liam E. Fouhy, Oladimeji Akinlawon, Chao‐Qiang Lai, Frederick Nusetor, José M. Ordovás, Kelsey M. Mangano, Katherine L. Tucker, Sabrina E. Noel   +8 more
wiley   +1 more source

Chromosome 20q Amplification Regulates in Vitro Response to Kinesin-5 Inhibitor

Cancer Informatics, 2008
We identified gene expression signatures predicting responsiveness to a Kinesin-5 (KIF11) inhibitor (Kinesin-5i) in cultured colon tumor cell lines.
Peter S. Linsley, Steven R. Bartz, Hongyue Dai, Matthew Biery, Teresa Ward, Sumire Kobayashi, Mao Mao, Aimee L. Jackson   +7 more
doaj  

Total Internal Reflection Fluorescence (TIRF) Single-Molecule Assay to Analyze the Motility of Kinesin

Bio-Protocol
The motile parameters of kinesin superfamily proteins are fundamental to intracellular transport. Single-molecule motility assays using total internal reflection fluorescence (TIRF) microscopy are a gold standard technique for measuring the motile ...
Tomoki Kita, Shinsuke Niwa
doaj   +1 more source

Kinesin-1 regulates dendrite microtubule polarity in Caenorhabditis elegans

eLife, 2013
In neurons, microtubules (MTs) span the length of both axons and dendrites, and the molecular motors use these intracellular ‘highways' to transport diverse cargo to the appropriate subcellular locations.
Jing Yan, Dan L Chao, Shiori Toba, Kotaro Koyasako, Takuo Yasunaga, Shinji Hirotsune, Kang Shen   +6 more
doaj   +1 more source

Maximum power operation of interacting molecular motors

, 2013
We study the mechanical and thermodynamic properties of different traffic models for kinesin which are relevant in biological and experimental contexts.
Golubeva, Natalia, Imparato, Alberto
core   +1 more source