Crystal structure of Zen4 in the apo state reveals a missing conformation of kinesin
Nature Communications, 2017 Kinesins are molecular motors that travel along microtubules through a nucleotide-dependent stepping mechanism. Here the authors present the crystal structure of Zen4 (kinesin-6) in an apo state that sheds light on a key stepping intermediate of kinesin.
Ruifang Guan +8 more
doaj +1 more source
Exploration of Biomarkers of Food Intake in a Caribbean Hispanic Population
Molecular Nutrition &Food Research, EarlyView.Validated BFIs show significant associations with food intake in an observational setting, and those associations were often modulated by non‐dietary factors. The identification of genotype‐BFI associations implies that the utility of a BFI could depend on common genetic differences.
Laurence D. Parnell +8 more
wiley +1 more source
Kinesin and dynein use distinct mechanisms to bypass obstacles
eLife, 2019 Kinesin-1 and cytoplasmic dynein are microtubule (MT) motors that transport intracellular cargoes. It remains unclear how these motors move along MTs densely coated with obstacles of various sizes in the cytoplasm.
Luke S Ferro +4 more
doaj +1 more source
Cooperative Responses of Multiple Kinesins to Variable and Constant Loads*
Journal of Biological Chemistry, 2011 Background: Multiple kinesin function is central to intracellular transport. Results: Unlike single-motor molecules, two kinesin velocities can depend on whether loads vary spatially or temporally.
K. Jamison, J. Driver, M. Diehl
semanticscholar +1 more source
From Fluctuations to Function: Unveiling the Role of Stochasticity in Life‐Like Systems
ChemSystemsChem, EarlyView.In this short review, we put forward the idea that randomly fluctuating, or stochastic, molecular events can and do play a role in the emergence of complex biological phenomena at longer length scales. There is a growing body of evidence of this occurring in natural systems, and we survey the computational and experimental attempts of researchers to ...
Aleksa Lakic, Alexander F. Mason
wiley +1 more source
Two Saccharomyces cerevisiae kinesin-related gene products required for mitotic spindle assembly. [PDF]
, 1992 M. Andrew Hoyt +3 more
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Are kinesins required for organelle trafficking in plant cells?
Frontiers in Plant Science, 2012 Plant cells exhibit active movement of membrane-bounded materials, which is more pronounced in large cells but is also appreciable in medium-sized cells and in tip-growing cells (such as pollen tubes and root hairs).
G. Cai, M. Cresti
semanticscholar +1 more source
MAP1B Variants Disrupt Neuronal Migration: Insights From Three Novel Families
Clinical Genetics, EarlyView.Pathogenic variants in MAP1B have recently emerged as a cause of neurodevelopmental disorders characterized by intellectual disability, epilepsy, and cortical malformations, including periventricular nodular heterotopia (PVNH) and polymicrogyria (PMG).
Jessica Archer +4 more
wiley +1 more source
Engineered kinesin motor proteins amenable to small-molecule inhibition
Nature Communications, 2016 The use of specific small molecule inhibitors can contribute to the study of kinesins' cellular functions. Here the authors develop a chemical-genetic approach to engineer kinesin motors that can be efficiently inhibited upon addition of cell-permeable ...
Martin F. Engelke +10 more
doaj +1 more source
Roles of kinesin and kinesin-like proteins in sea urchin embryonic cell division: evaluation using antibody microinjection. [PDF]
, 1993 Brent D. Wright +2 more
openalex +1 more source