In vitro Microtubule Bundling Assay under Physiological Conditions
Bio-Protocol, 2017 Kinesins play a role in organizing the mitotic spindle through the crosslinking of microtubules (MTs), made possible through binding sites at opposite ends of the holoenzyme.
Zach Geisterfer, Gin Tezuka, Li Tao
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Comprehensive comparative analysis of kinesins in photosynthetic eukaryotes-9
, 2011 Copyright information:Taken from "Comprehensive comparative analysis of kinesins in photosynthetic eukaryotes"BMC Genomics 2006;7():18-18.Published online 31 Jan 2006PMCID:PMC1434745.Copyright © 2006 Richardson et al; licensee BioMed Central Ltd.re ...
Mark P Simmons (72794) +2 more
core +1 more source
Targeting Cell Cycle Vulnerabilities in Cancers: Emerging Strategies for Therapeutic Development
Cancer Science, EarlyView.Dysregulated cell cycle control often involves alternative compensatory pathways in cancers to maintain its robustness but provide unique targetable vulnerabilities. We overview recent insights on cancer‐specific vulnerabilities across the cell cycle and discuss how these can be used to develop new therapeutic strategies.
Nana Kamakura +3 more
wiley +1 more source
Crystal structure of Zen4 in the apo state reveals a missing conformation of kinesin
Nature Communications, 2017 Kinesins are molecular motors that travel along microtubules through a nucleotide-dependent stepping mechanism. Here the authors present the crystal structure of Zen4 (kinesin-6) in an apo state that sheds light on a key stepping intermediate of kinesin.
Ruifang Guan +8 more
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Kinesin and dynein use distinct mechanisms to bypass obstacles
eLife, 2019 Kinesin-1 and cytoplasmic dynein are microtubule (MT) motors that transport intracellular cargoes. It remains unclear how these motors move along MTs densely coated with obstacles of various sizes in the cytoplasm.
Luke S Ferro +4 more
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Membrane‐type I metalloproteinase (MT1‐MMP): A key modifier of extracellular matrix microenvironment
The FEBS Journal, EarlyView.MT1‐MMP: A cellular microenvironment modifier. MT1‐MMP is a major cellular microenvironment modifier, maintaining collagen homeostasis by degrading excess collagen (A), creating a migration path in motile cells such as cancer cells (B), modulating local microenvironmental signaling by cleaving transmembrane receptors (C), and destroying tissue ...
Yoshifumi Itoh, Masaki Inada
wiley +1 more source
Molecular Motors in Blood–Brain Barrier Maintenance by Astrocytes
Brain SciencesThe blood–brain barrier (BBB) comprises distinct cell types, including endothelial cells, pericytes, and astrocytes, and is essential for central nervous system (CNS) homeostasis by selectively regulating molecular transport and maintaining integrity. In
Ana Filipa Sobral +4 more
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Comprehensive comparative analysis of kinesins in photosynthetic eukaryotes-4
, 2011 Copyright information:Taken from "Comprehensive comparative analysis of kinesins in photosynthetic eukaryotes"BMC Genomics 2006;7():18-18.Published online 31 Jan 2006PMCID:PMC1434745.Copyright © 2006 Richardson et al; licensee BioMed Central Ltd.lly ...
Mark P Simmons (72794) +2 more
core +1 more source
Huntingtin as an Actin Organizer: Structural and Functional Insights
Cytoskeleton, EarlyView.
M. Capizzi, S. Humbert
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RNF13 regulates the endolysosomal pathway through interaction with the small GTPase Arl8B
The FEBS Journal, EarlyView.The E3 ubiquitin ligase RNF13 functions as a regulatory scaffold, organizing Arl8B‐dependent complexes and tuning downstream signaling that controls endolysosomal organization and trafficking. In this model, wild‐type RNF13 associates with Arl8B on endolysosomes, whereas Arl8B (E22D/F55A) or RNF13 (L244A) variants weaken complex assembly, potentially ...
Audrey M. Sénécal +4 more
wiley +1 more source