Axon Initial Segment: Structure, Biological Functions, Diseases, and Therapeutic Targets
MedComm, Volume 7, Issue 4, April 2026.The axon initial segment (AIS) is a specialized axonal domain critical for maintaining neuronal polarity, action potential initiation, and network stability. This review summarizes the necessary elements for maintaining AIS structure and plasticity, discussing crucial biological functions of AIS in neuronal signaling and the neural circuit homeostasis,
Dong‐Yan Song +4 more
wiley +1 more source
Toxic mechanisms of amyloid oligomers and therapeutic strategies
Protein Science, Volume 35, Issue 4, April 2026.Abstract Amyloid oligomers are increasingly recognized as the major toxic contributors across protein‐misfolding disorders. In this review, we cover mechanistic evidence showing how these transient and structurally heterogeneous oligomers disrupt cellular homeostasis by: (i) permeabilizing lipid membranes and forming ion‐conducting pores; (ii ...
Magdalena I. Ivanova +2 more
wiley +1 more source
An improved phylogeny and revised taxonomy of Catillariaceae (Lecanoromycetes, Ascomycota)
TAXON, Volume 75, Issue 2, April 2026.Abstract The boundaries of the family Catillariaceae have largely remained untested through phylogenetic methods. Recent studies have led to the transfer of several genera previously classified in Catillariaceae to the newly described family Leprocaulaceae. Despite these changes, the distinction between Catillariaceae, Leprocaulaceae, and Catinariaceae
Måns Svensson +2 more
wiley +1 more source
Bacterial Extracellular Vesicles in Biomedical Research and Clinical Translation
Microbial Biotechnology, Volume 19, Issue 4, April 2026.Bacterial membrane vesicle biomedical applications. ABSTRACT Bacterial Extracellular Vesicles (bEVs) are lipid (single‐ or double‐bilayer) nanostructures secreted by virtually all bacteria that play fundamental roles in intercellular communication and have emerged as powerful, multifunctional tools in biomedicine. Their intrinsic ability to encapsulate
Alejandro Arce‐Rodríguez +2 more
wiley +1 more source
Identification of ceRNA Regulatory Networks Driven by the lncRNA NEAT1 in Multiple Myeloma
Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.ABSTRACT The lncRNA NEAT1 is overexpressed in multiple myeloma (MM) plasma cells and plays a key role in MM pathogenesis. NEAT1 is involved in ceRNA network in several cancers; however, data in MM are virtually absent. This study identified a NEAT1‐driven ceRNA network involving 96 miRNAs and 40 target genes, selected as concurrently downregulated in ...
Domenica Ronchetti +14 more
wiley +1 more source
Motor Protein Disruption Critically Alters Organelle Trafficking and Excitation-Contraction Coupling. [PDF]
eNeuroBansal H +5 more
europepmc +1 more source
Rules of the road: how to turn off kinesin motors. [PDF]
Biochem JTan Z, Missman A, Cianfrocco MA.
europepmc +1 more source
FOXM1 Signaling Network Transcriptionally Upregulates Expression of Proteins Involved in Mitotic Progression to Induce High Proliferation and Chromosomal Instability in Androgen Receptor-Low Triple-Negative Breast Cancer. [PDF]
Int J Mol SciRida P +5 more
europepmc +1 more source
Molecular Dynamics Simulations Provide Further Insights into the Allosteric Regulation of the Kinesin-5 Motor Domain by Loop 5. [PDF]
J Chem Inf ModelRodríguez-Santos G +5 more
europepmc +1 more source