Results 141 to 150 of about 15,656 (252)

Coronavirus Nsp3 Hijacks CLTC to Modulate Autophagosome Nucleation for Promoting DMV Formation and Viral Replication

Advanced Science, Volume 13, Issue 24, 27 April 2026.
In wild‐type cells, FIPV infection recruits CLTC to nsp3, facilitates DMV biogenesis and block autophagic flux to promote viral replication. CLTC knockout impairs autophagosome nucleation by reducing Beclin1–ATG14 complex expression. This disrupts the formation of autophagic precursor membranes, thereby preventing their hijacking by nsp3 for DMV ...
Juan Xu, Hang Li, Peng Liu, Zhe Jiao, Ding Zhang, Zhelin Su, Sai Niu, Jintao Zhang, Yuejun Shi, Guiqing Peng   +9 more
wiley   +1 more source

Proteomic profiling of brain organoids and extracellular vesicles identifies early Alzheimer's disease biomarkers and drug response heterogeneity

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) exhibits high genetic and clinical heterogeneity that limits therapeutic success. Patient‐derived brain organoids and their extracellular vesicles (EVs) provide physiologically relevant models to study disease mechanisms and individualized drug responses.
Rachel J. Boyd, Daiyun Dong, Ram Sagar, Anton Iliuk, Waqar Ahmed, Xenia Androni, Anton P. Porsteinsson, Paul B. Rosenberg, Constantine G. Lyketsos, Kenneth W. Witwer, Vasiliki Mahairaki   +10 more
wiley   +1 more source

The C‐Terminal Regions of TRAK Proteins Contain MIRO‐Independent Mitochondrial Localization Domains

Cytoskeleton, Volume 83, Issue 4, Page 187-199, April 2026.
ABSTRACT Current models suggest that MIRO GTPases anchor cytoskeletal motors to the mitochondrial outer membrane (MOM). However, our previous findings indicate that the unconventional myosin, MYO19, interacts with MIRO weakly and that a MIRO‐independent MOM‐localizing domain interacts more tightly with the MOM.
Lili Mitchell, Kathryn E. Reda, Hijab Fatima, Claudia E. Vasquez, Omar A. Quintero‐Carmona   +4 more
wiley   +1 more source

Mitochondria and the Actin Cytoskeleton in Neurodegeneration

Cytoskeleton, Volume 83, Issue 4, Page 200-210, April 2026.
ABSTRACT Mitochondrial dysfunction and cytoskeletal disorganization are widely recognized hallmarks of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS).
Shivani Tuli, Preet Patel, Aneri Shethji, David Gau   +3 more
wiley   +1 more source

Targeting KIF23 inhibits cell proliferation and primary chemoresistance in cervical cancer by inactivating the MYH9/MCM2/PCNA pathway

Clinical and Translational Medicine, Volume 16, Issue 4, April 2026.
Cisplatin treatment induces KIF23 expression in a concentration‐ and time‐dependent manner. KIF23 recruits USP7, which removes the K48‐linked ubiquitin chain of MYH9, thereby stabilising MYH9 and facilitating its nuclear transport. MYH9 recruits USP15, thereby stabilising MCM2, which, in turn, regulates the G1/S phase transition by binding to PCNA ...
Ying Zhu, Qian Wang, Yilin Zhang, Yahui Liu, Haini Fu, Zike Yang, Xiaojie Deng, Suiqun Guo   +7 more
wiley   +1 more source

Physical exercise mitigates chronic psychological stress‐induced vascular inflammation via the BDNF–Kif4–TARM1 axis

Clinical and Translational Medicine, Volume 16, Issue 4, April 2026.
Schematic model of the potential mechanisms by which physical exercise alleviates stress‐induced vascular inflammation via the BDNF–Kif4–TARM1 axis, revealing a neuroimmune‐mediated brain–heart axis that supports exercise therapy for psychogenic coronary artery disease. This graphical abstract was drawn with the FigDraw tool (www.fgdraw.com).
Xianghui Zheng, Yunqi Li, Peiyao Wang, Zhou Guo, Yuxuan Liu, Qi Liu, Baitao Wang, Huiyu Wang, Lizhi Zheng, Cien Li, Shuhong Liu, Shiyu Wang, Xinyu Hou, Xiaojun Wu, Yong Sun, Bo Yu, Yang Zheng, Jian Wu   +17 more
wiley   +1 more source

Genomic Analysis and Population Divergence Driven by Geographic Isolation in Neotetracus sinensis

Ecology and Evolution, Volume 16, Issue 4, April 2026.
We generated the first chromosome‐level reference genome for Neotetracus sinensis and resequenced populations from the Gaoligong and Wuliang Mountains to investigate divergence across the Hengduan “sky‐island” landscape. Genomic data reveal strong population structure with negligible gene flow and parallel demographic histories shaped by Pleistocene ...
Jianxuan Zhou, Nannan Chen, Weihao Dou, Zhonglai Luo, Libo Jiang, Meidong Jing, Fengtang Yang   +6 more
wiley   +1 more source

Protective Effect of LGG From Lophatherum Gracile Brongn. on Alcohol‐Injured HepG2 Cells and Exploration of Potential Mechanism

eFood, Volume 7, Issue 2, April 2026.
LGG was separated from L. gracile and its hepatoprotective effect was investigated. LGG significantly reduced the mortality, ROS and MDA content in alcohol‐injured liver cells. LGG up‐regulated 156 mRNAs (63 miRNAs) and down‐regulated 1529 mRNAs (35 miRNAs).
Yi‐Long Ma, Xin Guo, Zheng‐Fang Wu, Qian‐Lan Wu, Jing Li, Tian‐Le Mao, Zhi Li, Ya‐Fang Shang, Kiran Thakur, Zhao‐Jun Wei   +9 more
wiley   +1 more source

Kinesin: What Gives? [PDF]

Cell, 1998
openaire   +2 more sources

Heat‐Induced Toxicants: Sensory Appeal Distracts Consumers' Attention From Potential Toxicological Risks of Thermally Processed Foods

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
The central paradox of thermal processing of foods. (A) The application of heat (e.g., frying, baking, grilling) to food initiates complex chemical reactions, most notably the Maillard reaction and thermal degradation of protein, lipids, and carbohydrate. (B) These reactions create a desirable sensory experience characterized by enticing aromas, golden‐
Joachim Dotto Matondo, Abdulsudi Issa‐Zacharia   +1 more
wiley   +1 more source