Results 121 to 130 of about 25,177 (273)
Journal of the Chinese Chemical Society, EarlyView.Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley +1 more source
The velocity and run length of kinesins over the density of motors.
, 2016 (a) depicts the motions of the kinesin in (K + MΦ), (K + M+), and (K + M−) situations. Motors with an arrow directed to the right are moving kinesins. Motors with an arrow directed to the left are minus-end directed motors.
Woochul Nam (697172) +1 more
core +1 more source
Journal of the Chinese Chemical Society, EarlyView.The conventional “local activation–global inhibition” (LAGI) models utilize mean‐field averaging inhibition to suppress distant activations. As the inhibition diminishes with distance, LAGI models struggle to achieve robust single‐axis polarity in large systems.
Chin‐Lin Guo, Chiao‐Yu Tseng
wiley +1 more source
Bottom‐Up Synthesis and Active Assembly of DNA Networks by Biomolecular Nanomachines
Small, EarlyView.This study demonstrates a dynamic, bottom‐up assembly of DNA materials driven by two biomolecular nanomachines: DNA polymerase and kinesin. Through sequential chemical synthesis and motor‐driven mechanical manipulation, DNA fibrous networks are dynamically formed with complex morphologies unattainable by self‐assembly alone.
Farhana Afroze +11 more
wiley +1 more source
Journal of Experimental Botany, 2013 Rapid cell division and expansion in early fruit development are important phases for cucumber fruit yield and quality. Kinesin proteins are microtubule-based motors responsible for modulating cell division and enlargement.
Xueyong Yang +7 more
semanticscholar +1 more source
Regulation of the Cytoskeleton by Kinesins
, 2016 Kinesins are motor proteins that associate with microtubules. The position of the motor domain has been linked to kinesin function. While amino-terminal and carboxy-terminal localization of the motor domain is linked to cargo transport, kinesins with ...
Weil, Lauren Melissa
core
Effects of Tributyltin Chloride on Human Neuronal Differentiation and Mice Brain Development
Environmental Toxicology, EarlyView.ABSTRACT According to the developmental origins of health and disease hypothesis, perinatal exposure to an environmental toxicant during the development of the nervous system could cause a permanent cellular modification that may promote the appearance of neurodegenerative diseases at an older age.
Ester López‐Gallardo +10 more
wiley +1 more source
Engineering Heterodimeric Kinesins through Genetic Incorporation of Noncanonical Amino Acids
, 2018 Kinesins are commonly homodimers with two identical heavy chains (protomers) and play indispensable roles in many intracellular processes. Engineered heterodimeric kinesins with two distinct protomers are important tools for dissecting coordination and ...
Ryan A. Mehl (1313565) +3 more
core +1 more source
British Journal of Pharmacology, EarlyView.This study compares the molecular mechanisms of chemotherapy‐related peripheral neurotoxicity of two proteasome inhibitors, bortezomib and carfilzomib, using a multidisciplinary approach to reveal that, alongside shared effects on mitochondria structure and function, the more neurotoxic drug BTZ has specific effects on microtubules and mitochondrial ...
Federico Iseppon +27 more
wiley +1 more source