Results 111 to 120 of about 15,656 (252)
Cryo‐EM reveals ArnA contamination during purification of a ciliary protein complex
Acta Crystallographica Section D, EarlyView.ArnA contamination was independently observed during the purification of a soluble, low‐yield protein complex, leading to an unintended 3.23 Å resolution cryo‐EM structure. This work broadens recent findings and highlights ArnA as a recurrent His‐tag‐associated contaminant in Escherichia coli purification workflows.Endogenous Escherichia coli proteins ...
Xuguang Jiang, Masahide Kikkawa
wiley +1 more source
Mitochondrial Transfer in the Tumor Microenvironment
Cancer Science, EarlyView.Mitochondria are actively exchanged among tumor, immune, stromal, and neuronal cells within the tumor microenvironment. Such transfer rewires tumor metabolism, promotes immune evasion, and drives therapy resistance. Targeting mitochondrial transfer or harnessing mitochondrial transplantation represents a promising strategy to restore antitumor immunity
Ryo Omae +2 more
wiley +1 more source
Enhanced reaction kinetics in biological cells
, 2008 The cell cytoskeleton is a striking example of "active" medium driven out-of-equilibrium by ATP hydrolysis. Such activity has been shown recently to have a spectacular impact on the mechanical and rheological properties of the cellular medium, as well as
A Ajdari +33 more
core +1 more source
Cancer Science, EarlyView.Patient‐derived head and neck squamous cell carcinoma (HNSCC) cells were genomically and cytogenetically characterized, revealing actionable alterations and chromosomal instability. Targeted therapies suppressed growth according to EGFR amplification or PIK3CA mutation status.
Kazue Ito +17 more
wiley +1 more source
Interaction Between Motor Domains Can Explain the Complex Dynamics of Heterodimeric Kinesins
, 2007 Motor proteins are active enzyme molecules that play a crucial role in many biological processes. They transform the chemical energy into the mechanical work and move unidirectionally along rigid cytoskeleton filaments.
A. Yildiz +6 more
core +2 more sources
In vitro Microtubule Bundling Assay under Physiological Conditions
Bio-Protocol, 2017 Kinesins play a role in organizing the mitotic spindle through the crosslinking of microtubules (MTs), made possible through binding sites at opposite ends of the holoenzyme.
Zach Geisterfer, Gin Tezuka, Li Tao
doaj +1 more source
Tau Differentially Regulates Kinesin-1, Kinesin-2, and Kinesin-3 [PDF]
Biophysical Journal, 2019 Dominique V. Lessard +1 more
openaire +1 more source
Membrane‐type I metalloproteinase (MT1‐MMP): A key modifier of extracellular matrix microenvironment
The FEBS Journal, EarlyView.MT1‐MMP: A cellular microenvironment modifier. MT1‐MMP is a major cellular microenvironment modifier, maintaining collagen homeostasis by degrading excess collagen (A), creating a migration path in motile cells such as cancer cells (B), modulating local microenvironmental signaling by cleaving transmembrane receptors (C), and destroying tissue ...
Yoshifumi Itoh, Masaki Inada
wiley +1 more source
Generic principles of active transport
, 2006 Nonequilibrium collective motion is ubiquitous in nature and often results in a rich collection of intringuing phenomena, such as the formation of shocks or patterns, subdiffusive kinetics, traffic jams, and nonequilibrium phase transitions.
Franosch, Thomas +4 more
core +2 more sources
Crystal structure of Zen4 in the apo state reveals a missing conformation of kinesin
Nature Communications, 2017 Kinesins are molecular motors that travel along microtubules through a nucleotide-dependent stepping mechanism. Here the authors present the crystal structure of Zen4 (kinesin-6) in an apo state that sheds light on a key stepping intermediate of kinesin.
Ruifang Guan +8 more
doaj +1 more source