Results 171 to 180 of about 25,177 (273)

Molecular and Cell Biological Characterization of Patient‐Derived Head and Neck Squamous Carcinoma Cell Lines

Cancer Science, Volume 117, Issue 6, Page 1623-1634, June 2026.
Patient‐derived head and neck squamous cell carcinoma (HNSCC) cells were genomically and cytogenetically characterized, revealing actionable alterations and chromosomal instability. Targeted therapies suppressed growth according to EGFR amplification or PIK3CA mutation status.
Kazue Ito, Noriko Ishida, Shin Ito, Norihisa Shindo, Satoshi Souma, Mai Mochizuki, Haruna Fujimori, Keiichi Tamai, Takayuki Imai, Tomoko Yamazaki, Kazunori Yamaguchi, Kento Sasaki, Yuya Miyakura, Shigekazu Murakami, Yuka Unno, Naoki Asano, Yukinori Asada, Jun Yasuda   +17 more
wiley   +1 more source

Effects of Lysine Deacetylation Inhibition Alone or in Combination With Arimoclomol on TDP‐43 Proteinopathy

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
TDP‐43 pathology is a hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Peptidyl‐prolyl cis–trans isomerase A (PPIA), a foldase and chaperone protein, modulates TDP‐43 function in an acetylation‐dependent manner. Here, we show that inhibition of lysine deacetylation with vorinostat (SAHA) increases PPIA acetylation and ...
Serena Scozzari, Stefano Fabrizio Columbro, Monica Favagrossa, Massimo Tortarolo, Alfredo Cagnotto, Mario Salmona, Giovanni De Marco, Caterina Bendotti, Andrea Calvo, Laura Pasetto, Valentina Bonetto   +10 more
wiley   +1 more source

FTLD‐TDP‐43 With Motor Neuron Disease Pathology in an Autopsied Patient With Spastic Paraplegia‐30B Harbouring a Homozygous KIF1A Variant

Neuropathology and Applied Neurobiology, Volume 52, Issue 3, June 2026.
KIF1A‐associated neurological disorder (KAND) is a rare hereditary condition caused by KIF1A variants, affecting axonal transport and presenting with a wide clinical spectrum, including hereditary spastic paraplegia. This case of childhood‐onset KAND reveals FTLD‐TDP43 with motor neuron disease pathology emerging late in the disease course, suggesting ...
Rie Saito, Arika Hasegawa, Tetsuya Takahashi, Ryoko Koike, Norikazu Hara, Ramil Gabdulkhaev, Kishin Koh, Akio Kawakami, Yoshihisa Takiyama, Takeshi Ikeuchi, Akiyoshi Kakita   +10 more
wiley   +1 more source

Genome assembly and genome‐wide association studies decipher the genetic basis of isovitexin synthesis and yield traits in mungbean

The Plant Journal, Volume 126, Issue 5, June 2026.
Significance Statement A high‐quality mungbean genome was assembled and connected with domestication and GWAS analysis. EVM0030058 improved isovitexin in hairy roots. VrLFRH1 was found associated with yield‐related traits. This study presents a high‐quality chromosome‐level genome assembly of the southern Chinese mungbean cultivar Sulv1, with superior ...
Jinyang Liu, Suhua Zhang, Qiang Yan, Jingbin Chen, Yun Lin, Chenchen Xue, Ranran Wu, Prakit Somta, Xingxing Yuan, Yuan‐Ming Zhang, Xin Chen   +10 more
wiley   +1 more source

Unraveling the Dynamics of Oxytocin in Hypothalamic Neurons

Traffic, Volume 27, Issue 2, June 2026.
Oxytocin (OT) plays an important role in regulating social behavior, and dysregulation of the oxytocinergic system leads to social impairments, such as autism spectrum disorder. Central OT release is poorly understood. Using live‐cell imaging to track vesicle trajectories, combined with machine learning‐based classification, the analysis reveals ...
Beatriz Aznar‐Escolano, Vera Egorova, José Villanueva, Luis Miguel Gutiérrez, Virginia González‐Vélez, Amparo Gil, Sandra Jurado   +6 more
wiley   +1 more source

Kinesins and Myosins: Molecular Motors that Coordinate Cellular Functions in Plants.

Annual Review of Plant Biology, 2018
A. Nebenführ, R. Dixit
semanticscholar   +1 more source

Motor Protein Disruption Critically Alters Organelle Trafficking and Excitation-Contraction Coupling. [PDF]

eNeuro
Bansal H, Hana TA, Michael AH, Kamaridinova S, Bransford J, Ormerod KG.   +5 more
europepmc   +1 more source

Rules of the road: how to turn off kinesin motors. [PDF]

Biochem J
Tan Z, Missman A, Cianfrocco MA.
europepmc   +1 more source

Correction: Sensory cilia: How molecular motors can shape ciliary tip organization and diversity. [PDF]

J Cell Biol
Durand B.
europepmc   +1 more source

FOXM1 Signaling Network Transcriptionally Upregulates Expression of Proteins Involved in Mitotic Progression to Induce High Proliferation and Chromosomal Instability in Androgen Receptor-Low Triple-Negative Breast Cancer. [PDF]

Int J Mol Sci
Rida P, Andreae R, Bikhazi N, Jackson B, Wang I, Jinna N.   +5 more
europepmc   +1 more source