Results 131 to 140 of about 117,673 (373)
Nature Communications, 2016 Chromosomal instability (CIN) is a hallmark of cancer that contributes to tumour heterogeneity and other malignant properties. Aberrant centromere and kinetochore function causes CIN through chromosome missegregation, leading to aneuploidy ...
Weiguo Zhang +6 more
semanticscholar +1 more source
DSK1, a novel kinesin-related protein from the diatom Cylindrotheca fusiformis that is involved in anaphase spindle elongation. [PDF]
, 1996 We have identified an 80-kD protein that is involved in mitotic spindle elongation in the diatom Cylindrotheca fusiformis. DSK1 (Diatom Spindle Kinesin 1) was isolated using a peptide antibody raised against a conserved region in the motor domain of the ...
Brady, B +3 more
core +2 more sources
Advanced Intelligent Systems, EarlyView.DNA methylation and chromosomal copy number profiling have recently become essential for tumor diagnostics. The open‐source tool Mepylome enables this task in clinical routine. It combines several machine learning strategies and allows users to interactively examine respective data through an intuitive graphical interface. Running up to 65 times faster
Jon Brugger +6 more
wiley +1 more source
Mitotic spindle: kinetochore fibers hold on tight to interpolar bundles
European Biophysics Journal, 2017 When a cell starts to divide, it forms a spindle, a micro-machine made of microtubules, which separates the duplicated chromosomes. The attachment of microtubules to chromosomes is mediated by kinetochores, protein complexes on the chromosome.
I. Tolic
semanticscholar +1 more source
Autoantibody Response Toward Chromatin in Patients With Juvenile Idiopathic Arthritis
Arthritis &Rheumatology, EarlyView.Objective Patients with juvenile idiopathic arthritis (JIA) frequently exhibit antinuclear antibodies (ANAs), but the specific antigen target recognized by them and the presence of additional autoantibody specificities in patients with JIA remains elusive.
Viola Pitkänen +13 more
wiley +1 more source
A Randomized, Placebo‐Controlled Trial of Hydroxychloroquine in Incomplete Lupus
Arthritis &Rheumatology, EarlyView.Objective Patients with features of systemic lupus erythematosus (SLE) who do not fulfill classification criteria can be designated as incomplete lupus erythematosus (ILE). This condition includes individuals with a high risk of progression to SLE. Treatment of ILE may reduce symptoms, severity, and incidence of SLE.
Nancy J. Olsen +14 more
wiley +1 more source
BUB-1 promotes amphitelic chromosome biorientation via multiple activities at the kinetochore
eLife, 2018 Accurate chromosome segregation relies on bioriented amphitelic attachments of chromosomes to microtubules of the mitotic spindle, in which sister chromatids are connected to opposite spindle poles.
Frances Edwards +4 more
doaj +1 more source
Kinetochore-associated Mps1 regulates the strength of kinetochore-microtubule attachments via Ndc80 phosphorylation [PDF]
, 2021 Krishna K. Sarangapani +4 more
openalex +1 more source
Arthritis &Rheumatology, Accepted Article.Objective Complement component 4 (C4), encoded by C4A and C4B within the major histocompatibility complex (MHC) on chromosome 6, regulates the immune response and clears immune complexes. Variable copy number (CN) of C4 genes and retroviral HERV‐K element influence its function.
Javier Martínez‐López +23 more
wiley +1 more source
The Saccharomyces cerevisiae kinetochore
FEBS Letters, 1996 Accurate chromosome segregation is DApenDAnt on a specialized chromosomal structure, the kinetochore/centromere. The only essential constituent of the S. cerevisiae kinetochore established today is CBF3, a multisubunit complex that binds to S. cerevisiae centromere DNA.
Lechner, Johannes, Ortiz, Jennifer
openaire +2 more sources