Results 131 to 140 of about 115,854 (373)

Lateral and End-On Kinetochore Attachments Are Coordinated to Achieve Bi-orientation in Drosophila Oocytes.

PLoS Genetics, 2015
In oocytes, where centrosomes are absent, the chromosomes direct the assembly of a bipolar spindle. Interactions between chromosomes and microtubules are essential for both spindle formation and chromosome segregation, but the nature and function of ...
Sarah J Radford, Tranchau L Hoang, A Agata Głuszek, Hiroyuki Ohkura, Kim S McKim   +4 more
doaj   +1 more source

Molecular mechanisms facilitating the initial kinetochore encounter with spindle microtubules [PDF]

, 2017
The initial kinetochore encounter with a spindle microtubule (kinetochore capture) is one of the rate-limiting steps in establishing proper kinetochore–microtubule interaction during mitosis. Kinetochore capture is facilitated by multiple factors such as
Al-Bassam, Amberg, Athale, Bressan, Brun, Carazo-Salas, Cheerambathur, Clarke, Etsushi Kitamura, Fu, Gandhi, Gonen, Haruki, Hill, Janke, Kalinina, Kaláb, Kerppola, Khodjakov, Kirschner, Kitamura, Kitamura, Knop, Lim, Long, Ma, Maekawa, Maffini, Maiato, Marek Gierlinski, Maure, Michaelis, Miller, Natsume, Nicola O’Reilly, Nishimura, Ortiz, O’Reilly, Pasqualone, Peset, Richmond, Rieder, Shrestha, Straight, Straight, Sullivan, Sung, Tanaka, Tanaka, Tanaka, Tanaka, Tanaka, Tanaka, Tomoyuki U. Tanaka, Uhlmann, Vanya Vasileva, Wieczorek, Winey, Wollman, Yabuki, Yin, Zuojun Yue   +61 more
core   +2 more sources

A Forward Genetics Strategy for High‐Throughput Gene Identification via Precise Image‐Based Phenotyping of an Indexed EMS Mutant Library

Advanced Science, EarlyView.
The GeneHunter‐Gene‐Level Association (GH‐GLA) pipeline enables high‐throughput gene identification in an indexed EMS population of wheat cultivar KN9204. It identifies 5905 trait‐associated wheat genes and validates key regulators of kernel weight and spikelet architecture via gene editing and haplotype analysis.
Haojie Wang, Fujun Sun, Zeyu Shi, Yufeng Yang, Yi Ding, Tengteng Zhang, Caihong Zhao, Jingzhong Xie, Yaqian Zhang, Caihua Li, Wenqiang Tang, Junming Li, Xigang Liu, Shusong Zheng, Ni Jiang, Fei He, Shuzhi Zheng   +16 more
wiley   +1 more source

Anaphase B. [PDF]

, 2016
Anaphase B spindle elongation is characterized by the sliding apart of overlapping antiparallel interpolar (ip) microtubules (MTs) as the two opposite spindle poles separate, pulling along disjoined sister chromatids, thereby contributing to chromosome ...
Brust-Mascher, Ingrid, Civelekoglu-Scholey, Gul, Scholey, Jonathan M   +2 more
core   +2 more sources

Optogenetic control of kinetochore function

Nature Chemical Biology, 2017
Kinetochores act as hubs for multiple activities during cell division, including microtubule interactions and spindle checkpoint signaling. Each kinetochore can act autonomously, and activities change rapidly as proteins are recruited to or removed from ...
Huaiying Zhang, Chanat Aonbangkhen, Ekaterina V Tarasovetc, Edward R. Ballister, D. Chenoweth, M. Lampson   +5 more
semanticscholar   +1 more source

Unraveling the Genomic Architecture of Supernumerary (Iso‐)Dicentric Chromosomes in Dup15q Syndrome: Insight From a Systematic Literature‐Based Study

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Chromosomal aberrations, particularly copy‐number variations (CNVs), are prevalent in neurodevelopmental disorders (NDD) and significantly contribute to their pathogenesis. Copy‐number gains (CN gains) in 15q11‐q13, primarily consisting of a pseudo (iso‐)dicentric chromosome 15 [(i)dic(15)] or an interstitial duplication, are among the most ...
Sebastian Burkart, Markus Ries, Verena Romero, Karin Burau, Christian P. Schaaf, Maja Hempel   +5 more
wiley   +1 more source

AI-Assisted Forward Modeling of Biological Structures

Frontiers in Cell and Developmental Biology, 2019
The rise of machine learning and deep learning technologies have allowed researchers to automate image classification. We describe a method that incorporates automated image classification and principal component analysis to evaluate computational models
Josh Lawrimore, Ayush Doshi, Benjamin Walker, Kerry Bloom   +3 more
doaj   +1 more source

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint

Journal of Cell Biology, 2003
The proper segregation of sister chromatids in mitosis depends on bipolar attachment of all chromosomes to the mitotic spindle. We have identified the small molecule Hesperadin as an inhibitor of chromosome alignment and segregation.
Silke Hauf, R. Cole, S. LaTerra, C. Zimmer, G. Schnapp, Rainer Walter, A. Heckel, Jacques van Meel, C. Rieder, J. Peters   +9 more
semanticscholar   +1 more source

Keeping kinetochores on track

European Journal of Cell Biology, 2012
The multiple functions of kinetochores are reflected in their complex composition, with over a hundred different proteins, which self-associate in several functional subcomplexes. Most of these kinetochore proteins were identified over the last 10-12 years using a combination of genetic, cell biological, biochemical, and bioinformatic approaches in ...
openaire   +5 more sources

Dual pathway spindle assembly increases both the speed and the fidelity of mitosis [PDF]

, 2011
Roughly half of all animal somatic cell spindles assemble by the classical prophase pathway, in which the centrosomes separate ahead of nuclear envelope breakdown (NEBD).
Cross, R. A., Kaseda, Kuniyoshi, McAinsh, Andrew D.   +2 more
core   +2 more sources