Results 251 to 260 of about 115,854 (373)

Effects of chromosome number reduction on mitotic and meiotic stability in fission yeast. [PDF]

Genome Biol
Jiang Y, Jian Y, Nie L, Gu X, Lu Z, Chu Y, Liu X, Yao X, Zhou JQ, Zheng S, Fu C.   +10 more
europepmc   +1 more source

Merotelic Kinetochore Orientation Is a Major Mechanism of Aneuploidy in Mitotic Mammalian Tissue Cells [PDF]

, 2001
Daniela Cimini, Bonnie J. Howell, Paul S. Maddox, Alexey Khodjakov, Francesca Degrassi, Edward D. Salmon   +5 more
openalex   +1 more source

Multi‐omic analysis identifies biological processes underlying progressive interstitial lung disease in systemic sclerosis

The FEBS Journal, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease, and lung complications (ILD) are the main cause of death. This study compared SSc patients with and without lung disease to healthy volunteers. We found increased inflammation, specific proteins, and higher triglyceride levels linked to lung disease progression. These findings suggest triglycerides
Selena Bouffette, Perrine Soret, Alice Cole, Emmanuel Nony, Pierre Barbier Saint Hilaire, Grégory Leclerc, Lamine Alaoui, Audrey Aussy, Isabelle Wehrle, Aude Le Gall, Mark Coulon, Marc Pallardy, Voon Ong, Jeanne Allinne, Philippe Moingeon, David Abraham, Christopher P. Denton   +16 more
wiley   +1 more source

Preserving centromere identity: right amounts of CENP-A at the right place and time. [PDF]

Chromosome Res
Pukało Z, Medina-Pritchard B, Abad MA, Jeyaprakash AA.   +3 more
europepmc   +1 more source

Essential Roles of Drosophila Inner Centromere Protein (Incenp) and Aurora B in Histone H3 Phosphorylation, Metaphase Chromosome Alignment, Kinetochore Disjunction, and Chromosome Segregation [PDF]

, 2001
Richard R. Adams, Hélder Maiato, William C. Earnshaw, Mar Carmena   +3 more
openalex   +1 more source

High‐throughput screening identifies a previously undescribed checkpoint controlling mitotic progression in response to DNA damage

The FEBS Journal, EarlyView.
DNA damage can cause mitotic delay to allow DNA repair to occur. However, the mechanism underlying this is unclear. Here, we show that in response to cells entering mitosis with DNA damage, SOD1 restrains PP2a activity via oxidation of cysteine residues at the active site. This leads to a reduction in PP2a activity at the mitotic kinetochore, resulting
Nan Li, Rachel Gatenby, Thomas Walne, Caroline Daye, Steven Watson, Priya Lata, Stephen Brown, Ruth Thompson   +7 more
wiley   +1 more source

Lysine demethylase 4A is a centrosome‐associated protein required for centrosome integrity and genomic stability

The FEBS Journal, EarlyView.
KDM4A, a chromatin eraser, localizes to the centrosomes. Its demethylase activity is essential for maintaining centrosome number and integrity, independent of gene expression changes. Loss of KDM4A leads to centrosome amplification, pseudo‐bipolar spindle formation, and chromosome segregation errors, including micronuclei and chromatin bridges.
Pratim Chowdhury, Xiaoli Wang, Richard I. Han, Manga Motrapu, Ashley G. Boice, Yuya Nakatani, Sofia Vargas‐Hernandez, Julia F. Love, Claude Chew, Sandra L. Grimm, Dereck Mezquita, Frank M. Mason, Elisabeth D. Martinez, Cristian Coarfa, Cheryl L. Walker, Anna‐Karin Gustavsson, Ruhee Dere   +16 more
wiley   +1 more source

Downregulation of kinetochore-associated 1 gene increases lagging chromosomes and contributes to chromosomal instability in gastric cancer cells. [PDF]

Med Int (Lond)
Ohsaki D, Kanayama K.
europepmc   +1 more source

Localization of Mad2 to Kinetochores Depends on Microtubule Attachment, Not Tension

, 1998
Jennifer Waters, Rey Huei Chen, Andrew W. Murray, E. D. Salmon   +3 more
openalex   +2 more sources

Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints [PDF]

, 2001
Dimitrios A. Skoufias, Paul R. Andreassen, Françoise Lacroix, Leslie Wilson, Robert L. Margolis   +4 more
openalex   +1 more source