Results 1 to 10 of about 2,200 (117)

Mu-Opioid Receptor Agonist Induces Kir3 Currents in Mouse Peripheral Sensory Neurons – Effects of Nerve Injury [PDF]

Frontiers in Pharmacology, 2018
Neuropathic pain often arises from damage to peripheral nerves and is difficult to treat. Activation of opioid receptors in peripheral sensory neurons is devoid of respiratory depression, sedation, nausea, and addiction mediated in the brain, and ...
Philip Stötzner, Viola Spahn, Melih Ö. Celik, Dominika Labuz, Halina Machelska   +4 more
doaj   +4 more sources

Involvement of Inwardly Rectifying Potassium (Kir) Channels in the Toxicity of Flonicamid to Drosophila melanogaster [PDF]

Insects
Inwardly rectifying potassium (Kir) channels regulate essential physiological processes in insects and have been identified as potential targets for developing new insecticides.
Xuan Liu, Yuying Gao, Tengfei Liu, Hailiang Guo, Jizu Qiao, Jianya Su   +5 more
doaj   +2 more sources

GABAB receptors negatively modulate excitatory plasticity at the mossy fiber synapse onto parvalbumin-expressing basket and axo-axonic cells in the dentate gyrus [PDF]

Frontiers in Synaptic Neuroscience
IntroductionGABAB receptors (GABABRs) are important modulators of neuronal excitability, synaptic transmission and plasticity in principal cells (PCs). While at the cellular level they can inhibit synaptic transmission directly, at the network level, due
Rita M. Loureiro, Rita M. Loureiro, Sam A. Booker, Sam A. Booker, Sam A. Booker, Akos Kulik, Imre Vida   +6 more
doaj   +2 more sources

The Relevance of GIRK Channels in Heart Function [PDF]

Membranes, 2022
Among the large number of potassium-channel families implicated in the control of neuronal excitability, G-protein-gated inwardly rectifying potassium channels (GIRK/Kir3) have been found to be a main factor in heart control. These channels are activated
Ana Campos-Ríos, Lola Rueda-Ruzafa, José Antonio Lamas   +2 more
doaj   +2 more sources

An increase in regulatory T cells in peripheral blood correlates with an adverse prognosis for malignant melanoma patients – A study of T cells and natural killer cells [PDF]

Current Research in Immunology
Malignant melanoma is a highly immunogenic tumour, and the immune profile significantly influences cancer development and response to immunotherapy. The peripheral immune profile may identify high risk patients. The current study showed reduced levels of
Nanna Heldager Pedersen, Helene Bjerregaard Jeppesen, Gry Persson, Sophie Bojesen, Thomas Vauvert F. Hviid   +4 more
doaj   +2 more sources

Membrane-associated estrogen receptor α prevents the amyloid β-induced suppression of GIRK channel activity in hippocampal neurons from female mice [PDF]

Biology of Sex Differences
Background Amyloid β oligomers (oAβ) are a key pathogenic driver in Alzheimer’s Disease (AD). Neuronal G protein-gated inwardly rectifying K+ (GIRK/Kir3) channels are important regulators of neuronal excitability and prominent somatodendritic effectors ...
Haichang Luo, Ezequiel Marron Fernandez de Velasco, Jaeyoon Kim, Praseuth Yang, Paul Mermelstein, Joseph V. Bonventre, Paul S. Cooke, Kevin Wickman   +7 more
doaj   +2 more sources

Inwardly rectifying potassium channels: Critical insights for insect species and Apis mellifera [PDF]

Channels
Kir (inwardly rectifying potassium) channels that play key roles in maintaining potassium homeostasis, neuronal excitability, and osmoregulation have been cloned and characterized in a variety of insects.
Fabien Sourisseau, Craig A. Doupnik, Pierre Charnet, Mohamed Chahine   +3 more
doaj   +2 more sources

Effects of moderate static magnetic fields on voltage‐gated potassium ion channels in sympathetic neuron‐like PC12 cells [PDF]

Physiological Reports
While exposure of moderate static magnetic fields (SMF) can alter neuronal excitability, the effects on sympathetic neurons remain underexplored. This study investigates the effects of moderate SMF on Kv channels in the plasma membrane of sympathetic ...
Eri Kaneda, Takafumi Kawai, Yasushi Okamura, Shigeru Miyagawa   +3 more
doaj   +2 more sources

Adenosine in human atrial fibrillation modulates and re-distributes atria-wide dominant frequencies and directs to reentry ablation sites with improved outcome [PDF]

Scientific Reports
Understanding and therapy of persistent atrial fibrillation (AF) are suboptimal partly because the dynamics, mapping, and ablation of rotational activity that has been proposed to drive AF remain elusive.
David Calvo, Lucia Salinas, Pablo Martínez-Camblor, María Salgado, Ruth Álvarez-Velasco, Amaia Martínez-León, Minel Soroa, Daniel García-Iglesias, David Filgueiras-Rama, Juan José Gonzalez-Ferrer, Victoria Cañadas, Ricardo Salgado, Alba Cruz, Jorge Quintanilla, Andrés Redondo, Miguel Rodrigo, Julián Pérez-Villacastín, Nicasio Pérez-Castellano, Omer Berenfeld   +18 more
doaj   +2 more sources

Encephalopathy-causing mutations in Gβ1 (GNB1) alter regulation of neuronal GIRK channels

iScience, 2021
Summary: Mutations in the GNB1 gene, encoding the Gβ1 subunit of heterotrimeric G proteins, cause GNB1 Encephalopathy. Patients experience seizures, pointing to abnormal activity of ion channels or neurotransmitter receptors.
Haritha P. Reddy, Daniel Yakubovich, Tal Keren-Raifman, Galit Tabak, Vladimir A. Tsemakhovich, Maria H. Pedersen, Boris Shalomov, Sophie Colombo, David B. Goldstein, Jonathan A. Javitch, Amal K. Bera, Nathan Dascal   +11 more
doaj   +1 more source