British Journal of Pharmacology, Volume 180, Issue 16, Page 2140-2155, August 2023., 2023 Background and Purpose Drugs of abuse, including alcohol, increase dopamine in the mesocorticolimbic system via actions on dopamine neurons in the ventral tegmental area (VTA). Increased dopamine transmission can activate inhibitory G protein signalling pathways in VTA dopamine neurons, including those controlled by GABAB and D2 receptors.
Margot C. DeBaker +6 more
wiley +1 more source
The polarization of the G-protein activated potassium channel GIRK5 to the vegetal pole of Xenopus laevis oocytes is driven by a di-leucine motif. [PDF]
PLoS ONE, 2013 The G protein-coupled inwardly-rectifying potassium channels (known as GIRK or Kir3) form functional heterotetramers gated by G-βγ subunits. GIRK channels participate in heart rate modulation and neuronal postsynaptic inhibition in mammals.
Beatriz Díaz-Bello +4 more
doaj +1 more source
Tyrosine decaging leads to substantial membrane trafficking during modulation of an inward rectifier potassium channel [PDF]
, 2001 Tyrosine side chains participate in several distinct signaling pathways, including phosphorylation and membrane trafficking. A nonsense suppression procedure was used to incorporate a caged tyrosine residue in place of the natural tyrosine at position ...
Brandt, Gabriel S. +7 more
core +3 more sources
Cannabinoid 1 (CB1) receptor arrestin subtype‐selectivity and phosphorylation dependence
British Journal of Pharmacology, Volume 180, Issue 3, Page 369-382, February 2023., 2023 Background and purpose Arrestin or G protein bias may be desirable for novel cannabinoid therapeutics. Arrestin‐2 and arrestin‐3 translocation to CB1 receptor have been suggested to mediate different functions that may be exploited with biased ligands.
Jamie J. Manning +3 more
wiley +1 more source
C-terminal engineering of CXCL12 and CCL5 chemokines: functional characterization by electrophysiological recordings. [PDF]
PLoS ONE, 2014 Chemokines are chemotactic cytokines comprised of 70-100 amino acids. The chemokines CXCL12 and CCL5 are the endogenous ligands of the CXCR4 and CCR5 G protein-coupled receptors that are also HIV co-receptors.
Antoine Picciocchi +9 more
doaj +1 more source
KIR2DL2/2DL3-E(35) alleles are functionally stronger than -Q(35) alleles. [PDF]
, 2016 KIR2DL2 and KIR2DL3 segregate as alleles of a single locus in the centromeric motif of the killer cell immunoglobulin-like receptor (KIR) gene family. Although KIR2DL2/L3 polymorphism is known to be associated with many human diseases and is an important
Bao, Ju +5 more
core +1 more source
Excessive extracellular ATP desensitizes P2Y2 and P2X4 ATP receptors provoking surfactant impairment ending in ventilation-induced lung injury [PDF]
, 2018 Stretching the alveolar epithelial type I (AT I) cells controls the intercellular signaling for the exocytosis of surfactant by the AT II cells through the extracellular release of adenosine triphosphate (ATP) (purinergic signaling). Extracellular ATP is
Blankman, P. (Paul) +10 more
core +5 more sources
Identifying the role of pre-and postsynaptic GABAB receptors in behavior. [PDF]
, 2015 Although many reviews exist characterizing the molecular differences of GABAB receptor isoforms, there is no current review of the in vivo effects of these isoforms.
Boehm, Stephen L., Kasten, Chelsea R.
core +1 more source
Inhibition of G protein-activated inwardly rectifying K+ channels by different classes of antidepressants. [PDF]
PLoS ONE, 2011 Various antidepressants are commonly used for the treatment of depression and several other neuropsychiatric disorders. In addition to their primary effects on serotonergic or noradrenergic neurotransmitter systems, antidepressants have been shown to ...
Toru Kobayashi +2 more
doaj +1 more source
Ethanol Dependence Abolishes Monoamine and GIRK (Kir3) Channel Inhibition of Orbitofrontal Cortex Excitability [PDF]
Neuropsychopharmacology, 2017 Alcohol abuse disorders are associated with dysfunction of frontal cortical areas including the orbitofrontal cortex (OFC). The OFC is extensively innervated by monoamines, and drugs that target monoamine receptors have been used to treat a number of neuropsychiatric diseases, including alcoholism.
Sudarat, Nimitvilai +3 more
openaire +2 more sources