Results 91 to 100 of about 2,276,672 (229)

Can a Selective Serotonin Reuptake Inhibitor Act as a Glutamatergic Modulator?

Current Therapeutic Research, 2017
Sertraline (Zoloft) and fluoxetine (Prozac) are selective serotonin reuptake inhibitors whose antidepressant mechanism of action is classically attributed to an elevation of the extracellular levels of serotonin in the synaptic cleft.
Marcos Emilio Frizzo, PhD
doaj   +1 more source

Peripheral blood biomarkers in multiple sclerosis. [PDF]

, 2015
Multiple sclerosis is the most common autoimmune disorder affecting the central nervous system. The heteroge-neity of pathophysiological processes in MS contributes to the highly variable course of the disease and unpre-dictable response to therapies ...
Acheson, Achiron, Ada Francia, Agmon-Levin, Aktas, Alatab, Alexander, Amorini, Anderson, Antonella D'Ambrosio, Arbour, Arnson, Arrambide, Ascherio, Ascherio, Ascherio, Axtell, Bar-Or, Barkhof, Barkhof, Barteneva, Bartosik-Psujek, Berger, Bertolotto, Bertolotto, Bertolotto, Bianco, Bielekova, Biomarkers Definitions Working Group, Bittner, Bloomgren, Braun, Brettschneider, Brex, Browne, Burger, Bustamante, Bustamante, Buttmann, Buzas, Bălaşa, Cantorna, Carotenuto, Carson, Cermelli, Chabas, Chen, Ciusani, Clifford, Cocucci, Colombo, Comabella, Comabella, Comabella, Comabella, Comi, Confavreux, Correale, Corvol, Cox, Creeke, D'Aurizio, D'Souza, Dalmau, De Jager, De Jager, De Santis, Deisenhammer, Derfuss, Dhib-Jalbut, Distler, Doyle, Du, Egg, Ehling, Eikelenboom, Engelhardt, Esteller, Eulalio, Fabriek, Farrell, Fenoglio, Fialová, Fissolo, Fonalledas Perelló, Fox, Freedman, Friedman, Galboiz, Gandhi, Gao, Ge, Gianchecchi, Gilli, Gilli, Giovannoni, Goldberg, Goodin, Graber, Graber, Gresle, Gresle, Guo, Haak, Haller, Hanke, Harris, Hartung, Hayes, Hecker, Hecker, Hellerqvist, Hinson, Horstman, Huang, Huang, Hur, Inoue, Ioannidis, Jimenez, Johnson, Julien, Junker, Kacperska, Kallaur, Kamath, Kasper, Kayagaki, Keller, Kemppinen, Knox, Korn, Korteweg, Kuenz, Kuhle, Kurtzke, Kvistad, Kwon, Lai, Lalive, Laroni, Lassmann, Lassmann, Lau, Lemire, Leppert, Leray, Lewis, Liang, Lily, Lin, Lindberg, Linington, Liotta, Littman, Liu, Lolli, Lopatinskaya, Lopatinskaya, Losseff, Losseff, Losy, Lovett-Racke, Lowery-Nordberg, Lublin, Lublin, Lucchinetti, Lycke, Lünemann, Lünemann, Major, Malucchi, Marchi, Markiewicz, Markovic-Plese, Martinelli-Boneschi, Marzesco, Masuoka, Mayer, Mazzali, McDonald, Miller, Minagar, Minagar, Minagar, Minagar, Missler, Mitchell, Momen-Heravi, Morel, Moreno, Mowry, Munger, Muralidharan-Chari, Murugaiyan, Myers, Nelissen, Nelissen, Norling, O'Connell, O'Connell, Oliveira, Oliver, Opdenakker, Opsahl, Otaegui, Pachner, Pachner, Pachner, Paola Margutti, Papini, Park, Pawate, Pelajo, Pender, Petereit, Peterson, Petrocca, Poloni, Probstel, Qin, Qu, Quintana, Redell, Reder, Reindl, Reindl, Rieckmann, Rieder, Riverol, Romo-Tena, Rovaris, Rudick, Rudick, Rudick, Sadiq, Salama, Sato, Schwarz, Schwarz, Selmi, Semra, Sendid, Sharief, Sharief, Sharief, Sharief, Shaw, Sheremata, Sievers, Silber, Silvia Zamboni, Siman, Simona Pontecorvo, Simpson, Soldan, Soldan, Sospedra, Srivastava, Stewart, Stüve, Sundström, Sáenz-Cuesta, Sáenz-Cuesta, Tania Colasanti, Tao, Teunissen, Tintoré, Trabattoni, Trampe, Turiák, van Horssen, Varga, Vartanian, Verderio, Villoslada, Virtanen, Vogt, Vogt, Wandinger, Wang, Waschbisch, Waubant, Waubant, Waubant, Waubant, Weinstock-Guttman, Wekerle, Xiao, Yong, Yong, Yousry, Zahednasab, Zang, Zhang, Zhu, Zipp, Zisimopoulou, Zula   +298 more
core   +1 more source

Glial cells in the heart: Implications for their roles in health and disease

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of cardiac autonomic ganglia within epicardial fat pads (posterior heart surface shown), containing vagal postganglionic neuron cell bodies, associated fibres, and glia. These ganglia receive cholinergic input from vagal preganglionic neurons and adrenergic input from sympathetic postganglionic neurons ...
Svetlana Mastitskaya, Rimma Dugarova, Shefeeq M. Theparambil   +2 more
wiley   +1 more source

Vestibular role of KCNQ4 and KCNQ5 K+ channels revealed by mouse models [PDF]

, 2013
The function of sensory hair cells of the cochlea and vestibular organs depends on an influx of K+ through apical mechanosensitive ion channels and its subsequent removal over their basolateral membrane.
Chabbert, Christian, de Zeeuw, Chris I., Frens, Maartens, Heidenreich, Matthias, Jentsch, Thomas J., Spitzmaul, Guillermo Federico, Tolosa, Leonardo, Winkelman, Beerend H. J.   +7 more
core   +3 more sources

Aquaporin-4 and brain edema. [PDF]

, 2007
Aquaporin-4 (AQP4) is a water-channel protein expressed strongly in the brain, predominantly in astrocyte foot processes at the borders between the brain parenchyma and major fluid compartments, including cerebrospinal fluid (CSF) and blood.
A Lehmenkuhler, Alan S. Verkman, AS Verkman, AS Verkman, D Wenzel, DK Binder, DK Binder, DK Binder, DS Prough, GT Manley, H Wen, HJ Reulen, HK Kimelberg, I Klatzo, I Roberts, J Badaut, J Hu, J Li, J Li, JE Rash, JE Rash, K Oshio, KI Auguste, M Amiry-Moghaddam, M Amiry-Moghaddam, M Elkjaer, Marios C. Papadopoulos, MC Papadopoulos, MC Papadopoulos, MC Papadopoulos, NR Saunders, O Bloch, P Agre, P Padmawar, PM Rodier, S Nielsen, S Saadoun, S Saadoun, T Ma   +38 more
core   +2 more sources

Inhibitory effect of tumor necrosis factor-α on the basolateral Kir4.1/Kir5.1 channels in the thick ascending limb during diabetes.

Experimental and Therapeutic Medicine, 2021
Diabetic nephropathy is a major contributor to the morbidity and mortality of patients with diabetes. TNF-α expression is elevated during diabetes and is implicated in the pathogenesis of diabetic nephropathy; however, its underlying molecular mechanisms
Guoyan Zhang, Zhiming Lv, Yang Zhao, R. Chen, Xiangyu Zhan, Weiqun Wang, Hongyu Sui   +6 more
semanticscholar   +1 more source

Direct inhibition of basolateral Kir4.1/5.1 and Kir4.1 channels in the cortical collecting duct by dopamine.

Am J Physiol Renal Physiol, 2013
Zaika OL, Mamenko M, Palygin O, Boukelmoune N, Staruschenko A, Pochynyuk O.   +5 more
europepmc   +2 more sources

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, Volume 13, Issue 9, 13 February 2026.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Unveiling the mechanisms of neuropathic pain suppression: perineural resiniferatoxin targets Trpv1 and beyond

Frontiers in Neuroanatomy, 2023
Neuropathic pain arises from damage or disorders affecting the somatosensory system. In rats, L5 nerve injury induces thermal and mechanical hypersensitivity/hyperalgesia.
Safa Shehab, Hayate Javed, Aishwarya Mary Johnson, Saeed Tariq, Challagandla Anil Kumar, Bright Starling Emerald   +5 more
doaj   +1 more source

Cortical and Striatal Circuits in Huntington's Disease

, 2020
Huntington's disease (HD) is a hereditary neurodegenerative disorder that typically manifests in midlife with motor, cognitive, and/or psychiatric symptoms.
Blumenstock, S., Dudanova, I.
core   +1 more source