Results 111 to 120 of about 800,201 (140)
From metabolism to mood regulation: astrocytes as a driver of depression. [PDF]
Front Cell NeurosciNasu Y, Terunuma M.
europepmc +1 more source
Modulation of Kir4.1 and Kir4.1-Kir5.1 channels by extracellular cations [PDF]
Biochimica Et Biophysica Acta - Biomembranes, 2009 This work demonstrates that extracellular Na+ modulates the cloned inwardly rectifying K+ channels Kir4.1 and Kir4.1-Kir5.1. Whole-cell patch clamp studies on astrocytes have previously indicated that inward potassium currents are regulated by external ...
Mogens Andreasen, Dan Arne Klaerke
exaly +6 more sources
Modulation of Kir4.1 and Kir4.1–Kir5.1 channels by small changes in cell volume
Neuroscience Letters, 2009 Udgivelsesdato: 2009-Jun-26The K+ channels Kir4.1 and Kir4.1-Kir5.1 are expressed in the glial cells of the CNS and are involved in regulation of the K+ homeostasis.
Nanna MacAulay, Dan Arne Klaerke
exaly +5 more sources
High-potency block of Kir4.1 channels by pentamidine: Molecular basis [PDF]
European Journal of Pharmacology, 2017 Inward rectifier potassium (Kir) channels are expressed in almost all mammalian tissues and contribute to a wide range of physiological processes. Kir4.1 channel expression is found in the brain, inner ear, eye, and kidney.
Aldo A Rodríguez-Menchaca +2 more
exaly +4 more sources
Inhibition of Kir4.1 potassium channels by quinacrine. [PDF]
Brain Research, 2017 Inwardly rectifying potassium (Kir) channels are expressed in many cell types and contribute to a wide range of physiological processes. Particularly, Kir4.1 channels are involved in the astroglial spatial potassium buffering. In this work, we examined the effects of the cationic amphiphilic drug quinacrine on Kir4.1 channels heterologously expressed ...
Eloy G Moreno-Galindo +2 more
exaly +3 more sources
Glia, 2023 International audienceNeuronal rhythmogenesis in the spinal cord is correlated with variations in extracellular K + levels ([K + ] e). Astrocytes play important role in [K + ] e homeostasis and compute neuronal information. Yet it is unclear how neuronal
Frédéric Brocard +2 more
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Polyamine Permeation and Rectification of Kir4.1 Channels [PDF]
Channels, 2007 Inward rectifier K(+) (Kir) channels are expressed in multiple neuronal and glial cells. Recent studies have equated certain properties of exogenously expressed Kir4.1 channels with those of native K(+) currents in brain cells, as well as demonstrating the expression of Kir4.1 subunits in these tissues. There are nagging problems however with assigning
Misty Eaton +2 more
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Journal of Physiology, 2001 1. The inwardly rectifying potassium channel Kir5.1 appears to form functional channels only by coexpression with either Kir4.1 or Kir4.2. Kir4.1-Kir5.1 heteromeric channels have been shown to exist in vivo in renal tubular epithelia.
Stephen J. Tucker +2 more
exaly +2 more sources
Role of Kir4.1 channels in growth control of glia [PDF]
Glia, 2007 AbstractThe inwardly rectifying potassium channel Kir4.1 is widely expressed by astrocytes throughout the brain. Kir4.1 channels are absent in immature, proliferating glial cells. The progressive expression of Kir4.1 correlates with astrocyte differentiation and is characterized by the establishment of a negative membrane potential (> −70 mV) and an
Haruki Higashimori, Harald Sontheimer
exaly +3 more sources
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Chloroquine blocks the Kir4.1 channels by an open-pore blocking mechanism
European Journal of Pharmacology, 2017Kir4.1 channels have been implicated in various physiological processes, mainly in the K+ homeostasis of the central nervous system and in the control of glial function and neuronal excitability. Even though, pharmacological research of these channels is very limited.
Eloy G Moreno-Galindo +2 more
exaly +5 more sources