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Brain Sciences, 2020 Epilepsy, characterized by recurrent seizures, affects 1% of the general population. Interestingly, 25% of diabetics develop seizures with a yet unknown mechanism. Hyperglycemia downregulates inwardly rectifying potassium channel 4.1 (Kir4.1) in cultured
Serguei N Skatchkov +2 more
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Inwardly Rectifying Potassium Channel Kir4.1 as a Novel Modulator of BDNF Expression in Astrocytes
International Journal of Molecular Sciences, 2018 Brain-derived neurotrophic factor (BDNF) is a key molecule essential for neural plasticity and development, and is implicated in the pathophysiology of various central nervous system (CNS) disorders. It is now documented that BDNF is synthesized not only
Yukihiro Ohno +2 more
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Astrocyte Kir4.1 expression level territorially controls excitatory transmission in the brain [PDF]
Cell ReportsIntense brain activity elevates extracellular potassium, potentially leading to overexcitation and seizures. Astrocytes are crucial for restoring healthy potassium levels, and an emerging focus on their Kir4.1 channels has reopened the quest into the ...
Kirill Volynski +2 more
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KCNJ10 (Kir4.1) potassium channel knockout abolishes endocochlear potential
American Journal of Physiology-Cell Physiology, 2002Stria vascularis of the cochlea generates the endocochlear potential and secretes K+. K+ is the main charge carrier and the endocochlear potential the main driving force for the sensory transduction that leads to hearing. Stria vascularis consists of two barriers, marginal cells that secrete potassium and basal cells that are coupled via gap junctions
Daniel C, Marcus +3 more
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Inhibition of astroglial Kir4.1 channels by selective serotonin reuptake inhibitors
Brain Research, 2007The inwardly rectifying K+ (Kir) channel Kir4.1 is responsible for astroglial K+ buffering. We recently found that tricyclic antidepressants (TCAs) inhibit Kir4.1 channel currents, which suggests that astroglial Kir currents might be involved in the pharmacological action of antidepressants.
Yukihiro, Ohno +4 more
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Kir4.1 channel- A universal target in ALS glia
2022Mitrečić D, Petravić D, editors. Abstracts: International Conference on Neurological Disorders and Neurorestoration; 2022 May 19-22; Dubrovnik, Croatia. Zagreb: Department of Neurology, University Hospital Centre Zagreb: 2022. p. 13. (Neurologia Croatica; Vol. 71; Suppl. 2).
Anđus, Pavle +3 more
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The Journal of Pharmacology and Experimental Therapeutics, 2007
The inwardly rectifying K(+) (Kir) channel Kir4.1 is responsible for astroglial K(+) buffering. We examined the effects of nortriptyline, a tricyclic antidepressant (TCA), on Kir4.1 channel currents heterologously expressed in HEK293T cells, using a whole-cell patch-clamp technique. Nortriptyline (3-300 microM) reversibly inhibited Kir4.1 currents in a
Suwen, Su +5 more
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The inwardly rectifying K(+) (Kir) channel Kir4.1 is responsible for astroglial K(+) buffering. We examined the effects of nortriptyline, a tricyclic antidepressant (TCA), on Kir4.1 channel currents heterologously expressed in HEK293T cells, using a whole-cell patch-clamp technique. Nortriptyline (3-300 microM) reversibly inhibited Kir4.1 currents in a
Suwen, Su +5 more
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Journal of Theoretical Biology
Astrocytes have an important role in the indirect regulation of neuronal excitability. The abnormalities of their ion channels cause neurons to discharge abnormally, which may induce seizures. The inwardly rectifying potassium channel 4.1 (Kir4.1 channel) and the voltage-gated calcium channel (VGCC) of an astrocyte play important roles in maintaining ...
Yu Rui, Shu Liu, Suyu Liu
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Astrocytes have an important role in the indirect regulation of neuronal excitability. The abnormalities of their ion channels cause neurons to discharge abnormally, which may induce seizures. The inwardly rectifying potassium channel 4.1 (Kir4.1 channel) and the voltage-gated calcium channel (VGCC) of an astrocyte play important roles in maintaining ...
Yu Rui, Shu Liu, Suyu Liu
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Role of spinal astrocytic Kir4.1 channels in neuropathic pain
Rôle des canaux astrocytaires spinaux Kir4.1 dans la douleur neuropathique La douleur neuropathique, qui résiste souvent aux analgésiques courants, représente un problème de santé majeur. Les mécanismes physiopathologiques de la douleur neuropathique sont multifactoriels et méconnus.openaire +1 more source