Results 111 to 120 of about 2,276,672 (229)

Retinal Macroglial Responses in Health and Disease [PDF]

, 2016
Due to their permanent and close proximity to neurons, glial cells perform essential tasks for the normal physiology of the retina. Astrocytes andM¨uller cells (retinal macroglia) provide physical support to neurons and supplement them with several ...
Gallego Collado, Beatriz Isabel, Hoz Montañana, Rosa de, Ramirez Sebastian, Jose Manuel, Ramírez Sebastián, Ana Isabel, Rojas López, María Blanca, Salazar Corral, Juan José, Triviño Casado, Alberto   +6 more
core   +2 more sources

The contribution of TWIK-1 channels to astrocyte K+ current is limited by retention in intracellular compartments

Frontiers in Cellular Neuroscience, 2013
TWIK-1 two-pore domain K+ channels are expressed abundantly in astrocytes. In the present study, we examined the extent to which TWIK-1 contributes to the linear current-voltage (I-V) relationship (passive) K+ membrane conductance, a dominant ...
Wei eWang, Adhytia ePutra, Gary P. Schools, Baofeng eMa, Haijun eChen, Leonard K. Kaczmarek, Jacques eBarhanin, Florian eLesage, Min eZhou   +8 more
doaj   +1 more source

Brain Aquaporin 4 in Hyperammonemia [PDF]

, 2010
In liver failure, congenital enzymopathies of the urea cycle, and other disorders, ammonia may not be properly detoxified and thus hyperammonemia ensues.
Cauli, Omar
core  

Unraveling the Role of Ensheathing Cells and Perineural Fibroblasts in Olfactory Neurogenesis

Glia, Volume 73, Issue 12, Page 2407-2426, December 2025.
Main Points DEOs are similar to satellite glial cells. DECs react to neuronal injury by promoting lipid metabolism, but do not proliferate. ECs reduce gap junctions upon neuronal injury. Perineural fibroblasts also contribute to the injury response. ABSTRACT During development and following injury‐induced neurogenesis, olfactory ensheathing cells (OECs)
Katja Senf, Sandor Nietzsche, Martin Westermann, Eva M. Neuhaus   +3 more
wiley   +1 more source

Lack of significant association between mutations of KCNJ10 or FOXI1 and SLC26A4 mutations in pendred syndrome/enlarged vestibular aqueducts [PDF]

, 2013
Pendred syndrome is a common autosomal recessive disorder causing deafness. Features include sensorineural hearing impairment, goitre, enlarged vestibular aqueducts (EVA) and occasionally Mondini dysplasia.
Bitner-Glindzicz, M, Differ, AM, Jenkins, L, Landa, P, Rajput, K   +4 more
core   +2 more sources

LRRC8A Regulates Outer Hair Cell Volume and Electromotility and is Required for Hearing

Advanced Science, Volume 12, Issue 41, November 6, 2025.
This study identifies LRRC8A‐dependent volume‐regulated anion channels (VRACs) as essential for cochlear outer hair cells' electromotility and auditory signal amplification. LRRC8A deficiency disrupts cell volume control, impairs auditory sensitivity, and causes deafness, while targeted LRRC8A re‐expression restores auditory function.
Shengnan Wang, Yuehui Xi, Qiaojun Fang, Sai Shi, Fei Wang, Fuyu Xian, Zhongyang Zhang, Yuxin Yang, Xishuo Jin, Xiaomin Wang, Chen Cao, Hailin Zhang, Nikita Gamper, Zhigang Xu, Haitao Shen, Ping Lv   +15 more
wiley   +1 more source

Role of astroglial Kir4.1 channels in the pathogenesis and treatment of epilepsy

, 2014
The inwardly rectifying potassium (Kir) channel subunit Kir4.1 is specifically expressed in brain astrocytes and Kir4.1-containing channels (Kir4.1 channels) mediate astroglial spatial potassium (K + ) buffering.
Y. Ohno, Kentaro Tokudome, Naofumi Kunisawa, H. Iha, M. Kinboshi, Takahiro Mukai, T. Serikawa, S. Shimizu   +7 more
semanticscholar   +1 more source

Astroglial Kir4.1 potassium channel deficit drives neuronal hyperexcitability and behavioral defects in Fragile X syndrome mouse model

Nature Communications
Fragile X syndrome (FXS) is an inherited form of intellectual disability caused by the loss of the mRNA-binding fragile X mental retardation protein (FMRP). FXS is characterized by neuronal hyperexcitability and behavioral defects, however the mechanisms
Danijela Bataveljic, Helena Pivonkova, Vidian de Concini, Betty Hébert, Pascal Ezan, Sylvain Briault, Alexis-Pierre Bemelmans, Jacques Pichon, Arnaud Menuet, Nathalie Rouach   +9 more
doaj   +1 more source

Idiopathic epilepsy of childhood and potassium ion channels [PDF]

, 2007
Potassium can affect the development of common seizure type and can be defined seizure susceptibility allele. The existence of inward-rectifying potassium (Kir) channels was first recognized half a century ago. The biophysical fingerprint of Kir channels
Dai, Alper I, Wasay, Mohammad
core   +1 more source

Astrocytes differentially respond to inflammatory autoimmune insults and imbalances of neural activity [PDF]

, 2013
BACKGROUND: Neuronal activity intimately communicates with blood flow through the blood–brain barrier (BBB) in the central nervous system (CNS). Astrocyte endfeet cover more than 90% of brain capillaries and interact with synapses and nodes of Ranvier ...
Chen Gu, Peter Jukkola, Tomas Guerrero, Victoria Gray   +3 more
core   +1 more source