Results 81 to 90 of about 2,276,672 (229)

EAST syndrome: Clinical, pathophysiological, and genetic aspects of mutations in KCNJ10 [PDF]

, 2016
EAST syndrome is a recently described autosomal recessive disorder secondary to mutations in KCNJ10 (Kir4.1), a gene encoding a potassium channel expressed in the brain, eye, ear and kidney.
Abdelhadi, O, Bockenhauer, D, Iancu, D, Kleta, R, Stanescu, H   +4 more
core   +1 more source

Fast ripple‐delta coupling as an early biomarker for post‐traumatic epileptogenesis in repetitive brain injury

Epilepsia Open, EarlyView.
Abstract Objective Traumatic brain injury (TBI) can induce posttraumatic epilepsy (PTE), but early biomarkers for epileptogenesis are lacking. We aimed to investigate electrographic biomarkers before and during posttraumatic seizure development. Methods We used a repetitive diffuse TBI model in mice with continuous video‐EEG monitoring up to 4½ months ...
Oleksii Shandra, Dzenis Mahmutovic, Biswajit Maharathi, Md Adil Arman, Michael J. Benko, Owen Leitzel, Pritom Kumar Saha, Stefanie Robel   +7 more
wiley   +1 more source

Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity

eLife, 2018
Glial support is critical for normal axon function and can become dysregulated in white matter (WM) disease. In humans, loss-of-function mutations of KCNJ10, which encodes the inward-rectifying potassium channel KIR4.1, causes seizures and progressive ...
Lucas Schirmer, Wiebke Möbius, Chao Zhao, Andrés Cruz-Herranz, Lucile Ben Haim, Christian Cordano, Lawrence R Shiow, Kevin W Kelley, Boguslawa Sadowski, Garrett Timmons, Anne-Katrin Pröbstel, Jackie N Wright, Jung Hyung Sin, Michael Devereux, Daniel E Morrison, Sandra M Chang, Khalida Sabeur, Ari J Green, Klaus-Armin Nave, Robin JM Franklin, David H Rowitch   +20 more
doaj   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Aquaporin water channels in the nervous system. [PDF]

, 2013
The aquaporins (AQPs) are plasma membrane water-transporting proteins. AQP4 is the principal member of this protein family in the CNS, where it is expressed in astrocytes and is involved in water movement, cell migration and neuroexcitation.
A Frigeri, A Kimura, A Marmarou, A Rojek, A Rossi, A Rossi, A Tanghe, A Warth, AJ Wilson, AJ Yool, Alan S. Verkman, AS Filippidis, AS Thrane, AS Verkman, AS Verkman, AS Verkman, B Nico, B Nico, B Wu, B Yang, B Yang, B Yang, BG Nandasena, BJ Jin, BJ Jin, C Geers, C Nicholson, CM Niemietz, CS Furman, D Dolman, DC Lu, DJ Lee, DJ Lee, DK Binder, DK Binder, DK Binder, DK Binder, DM Wingerchuk, DR Johnson, E Ishihara, E Migliati, E Solenov, EA Nagelhus, EA Nagelhus, F Pisani, G Soveral, GM Preston, GP Nicchia, GP Nicchia, GP Nicchia, GT Charras, GT Manley, H Gao, H Ikota, H Wolburg, H Wolburg, H Zhang, H Zhang, H Zhang, I Kleffner, II Arcienega, J Badaut, J Badaut, J Badaut, J Fischbarg, J Hu, J Li, J Li, J Ratelade, J Ruiz-Ederra, JD Ho, JD Neely, JD Neely, JE Rash, JJ Iliff, JL Bennett, JL Venero, JM Carbrey, JM Crane, JM Crane, JM Verbavatz, JS Hub, K Heuser, K Oshio, K Oshio, K Oshio, KI Auguste, L Li, L Tradtrantip, L Tradtrantip, L Tradtrantip, M Amiry-Moghaddam, M Amiry-Moghaddam, M Amiry-Moghaddam, M Eilert-Olsen, M Herrera, M Iwamoto, M Matiello, M Nagahama, M Ozu, M Rabinovitch, Marios C. Papadopoulos, MB Arciszewski, MC Papadopoulos, MC Papadopoulos, MC Papadopoulos, MC Papadopoulos, MC Papadopoulos, MC Sun, MG Mola, MJ Tait, MM Thi, MS Hsu, NH Bass, NN Haj-Yasein, O Bloch, O Bloch, P Hofman, P Padmawar, PW Phuan, R Aharon, RA Fenton, S Jarius, S Nielsen, S Nielsen, S Noell, S Saadoun, S Saadoun, S Saadoun, S Saadoun, S Saadoun, S Saadoun, S Saadoun, S Saadoun, S Strohschein, SD Shields, SM Richardson, SR Hinson, T Ma, T Ma, T Tani, T Walz, V Benfenati, VA Lennon, VA Lennon, VA Skucas, VJ Huber, VJ Huber, VM Loitto, W Yang, X Feng, X Yao, X Yu, XN Zeng, Y Cui, Y Fan, Y Fan, Y Hiroaki, Y Yukutake, Z Li, Z Vajda, Z Zador   +161 more
core   +1 more source

Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against [PDF]

, 2023
Multiple sclerosis (MS) is a progressive inflammatory demyelinating disease of the CNS. Increasing evidence suggests that vulnerable neurons in MS exhibit fatal metabolic exhaustion over time, a phenomenon hypothesized to be caused by chronic ...
Acuna, Claudio, Budde, Thomas, Calabresi, Peter A., Campos, Joaquin, Cerina, Manuela, Chavali, Manideep, Cordano, Christian, Cruz-Herranz, Andres, D'Este, Elisa, Delank, Anna, Disse, Paul, Dyckow, Julia, Engelhardt, Maren, Fazio, Luca, Fitzgerald, Kathryn C., Friese, Manuel A., Gharagozloo, Marjan, Green, Ari J., Heidenreich, Matthias, Hemmer, Bernhard, Jentsch, Thomas J., Kapell, Hannah, Lerma-Martin, Celia, Mayer, Christina, Meuth, Seven G., Moebius, Wiebke, Muentefering, Thomas, Naik, Venu Narayanan, Nave, Klaus-Armin, Platten, Michael, Probstel, Anne-Katrin, Rowitch, David H., Rychlik, Nicole, Sabeur, Khalida, Schirmer, Lucas, Schwarz, Sophia, Seebohm, Guiscard, Sin, Jung Hyung, Sonner, Jana K., Srivastava, Rajneesh, Stadelmann, Christine, Zulji, Amel   +41 more
core   +1 more source

Detection of potassium channel KIR4.1 antibodies in Multiple Sclerosis patients

Journal of Immunological Methods, 2017
The presence of KIR4.1 antibodies has been proposed to be a characteristic of Multiple Sclerosis (MS). This could have a significant impact on disease management. However, the validation of the initial findings has failed till date. Conflicting results have been attributed to difficulties in isolating the lower-glycosylated (LG) KIR4.1 expressed in ...
Marnetto F., Valentino P., Caldano M., Bertolotto A.   +3 more
openaire   +3 more sources

Kir4.1 Channel Expression Is Essential for Parietal Cell Control of Acid Secretion [PDF]

Journal of Biological Chemistry, 2011
Kir4.1 channels were found to colocalize with the H(+)/K(+)-ATPase throughout the parietal cell (PC) acid secretory cycle. This study was undertaken to explore their functional role. Acid secretory rates, electrophysiological parameters, PC ultrastructure, and gene and protein expression were determined in gastric mucosae of 7-8-day-old Kir4.1 ...
Song, Penghong, Groos, Stephanie, Riederer, Brigitte, Feng, Zhe, Krabbenhoeft, Anja, Manns, Michael P., Smolka, Adam, Hagen, Susan J., Neusch, Clemens, Seidler, Ursula   +9 more
openaire   +3 more sources

Brain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model

Small Methods, EarlyView.
This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto, Nine R. Kok, Philipp C. Hauger, Manon Karsten‐van Diepen, Michael de Kok, Nanne J. Paauw, Susanne M. A. van der Pol, Joline P. Nugteren‐Boogaard, Peter L. Hordijk, Stephanie D. Beekhuis‐Hoekstra, Susan Gibbs, Nienke M. de Wit, Helga E. de Vries   +12 more
wiley   +1 more source

Kir4.1/Kir5.1 channels possess strong intrinsic inward rectification determined by a voltage-dependent K+-flux gating mechanism

The Journal of General Physiology, 2021
Inward rectification of Kir channels is attributed to a voltage-dependent block of the channel pore by intracellular cations. Marmolejo-Murillo et al.
L. G. Marmolejo-Murillo, I. Aréchiga-Figueroa, Eloy G. Moreno-Galindo, T. Ferrer, Rodrigo Zamora-Cárdenas, R. Navarro-Polanco, J. Sánchez-Chapula, Aldo A. Rodríguez-Menchaca   +7 more
semanticscholar   +1 more source