Results 161 to 170 of about 2,756 (195)

Molecular Mechanisms of Dysregulated LH and FSH Secretion in Human Reproductive Failure. [PDF]

Biomedicines
Zikopoulos A, Moustakli E, Potiris A, Paraschos VS, Katopodis P, Machairoudias P, Antsaklis P, Kathopoulis N, Anagnostaki I, Stavros S.   +9 more
europepmc   +1 more source

Hypothyroidism Alters Uterine Kisspeptin System and Activity Modulators in Cyclic Rats. [PDF]

Int J Mol Sci
da Silva TQM, Barbosa EM, Santos LC, Oliveira LS, Cunha MCDSG, de Macedo IO, Martins BGC, Oliveira CL, Rodrigues NP, Araújo-Lopes R, Szawka RE, Silva JF.   +11 more
europepmc   +1 more source

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Physiological and pathological roles of locally expressed kisspeptin and KISS1R in the endometrium

Human Reproduction, 2023
Abstract Kisspeptins, encoded by the KISS1 gene, are a family of polypeptides that bind the kisspeptin receptor (KISS1R) to perform biological functions. Produced mainly in the hypothalamus, these neuropeptides regulate the pulsatile secretion of GnRH and trigger the hypothalamus–pituitary–gonadal axis.
Li Nie, Jieyu Zhang, Dong Zhi Yuan
exaly   +3 more sources

Conformational Change in the Ligand-Binding Pocket via a KISS1R Mutation (P147L) Leads to Isolated Gonadotropin-Releasing Hormone Deficiency [PDF]

Journal of the Endocrine Society, 2017
Context: Kisspeptin receptor (KISS1R) is expressed in hypothalamic gonadotropin-releasing hormone neurons and responsible for pubertal onset and reproductive functions. KISS1R mutations remain a rare cause of congenital hypogonadotropic hypogonadism (CHH)
Tadato Yonekawa, Hideyuki Sakoda, Msamitsu Nakazato   +2 more
exaly   +1 more source

KISS1/KISS1R and Breast Cancer: Metastasis Promoter

Seminars in Reproductive Medicine, 2019
AbstractKisspeptins (KPs), peptide products of the kisspeptin-1 (KISS1) gene, are the endogenous ligands for the KISS1 receptor, KISS1R, which is a G protein-coupled receptor. In many human tumors, KISS1 functions as a metastasis-suppressor gene and KISS1/KISS1R signaling has antimetastatic and tumor-suppressor roles. On the contrary, emerging evidence
Stephania, Guzman, Muriel, Brackstone, Frederic, Wondisford, Andy V, Babwah, Moshmi, Bhattacharya   +4 more
openaire   +2 more sources

Changes in Methylation Patterns of Kiss1 and Kiss1r Gene Promoters across Puberty

Genetics & Epigenetics, 2013
The initiation of mammalian puberty is underpinned by an increase in Kisspeptin (Kiss1) signaling via its receptor (Kiss1r/GPR54) on gonadotropin-releasing hormone (GnRH) neurons. Animals and humans with loss-of-function mutations in Kiss1 or Kiss1r fail to go through puberty.
Jo-Ann Stanton, Christine Jasoni, Neil Gemmell   +2 more
exaly   +3 more sources