Results 171 to 180 of about 2,756 (195)

Role of the Kiss1/Kiss1r system in the regulation of pituitary cell function

Molecular and Cellular Endocrinology, 2016
Kisspeptin (Kiss1) is an amidated neurohormone that belongs to the RF-amide peptide family, which has a key role in the control of reproduction. Specifically, kisspeptin regulates reproductive events, including puberty and ovulation, primarily by activating the surface receptor Kiss1r (aka GPR54), at hypothalamic gonadotropin-releasing hormone (GnRH ...
Justo P Castaño, Manuel D Gahete, Manuel Tena-Sempere   +2 more
exaly   +3 more sources

Mutational analysis of KISS1 and KISS1R in idiopathic central precocious puberty

Journal of Pediatric Endocrinology and Metabolism, 2014
The genetic background of idiopathic central precocious puberty (ICPP) is not well understood. The genetic activation of pubertal onset is thought to arise from the effect of multiple genes. Familial ICPP has been reported suggesting the existence of monogenic causes of ICPP.
Leticia Silveira
exaly   +3 more sources

Presence and function of kisspeptin/KISS1R system in swine ovarian follicles

Theriogenology, 2018
Kisspeptin and its receptor KISS1R are involved in the neuroendocrine regulation of mammalian reproduction and their role on follicular development and function can be hypothesized. The present work was designed to confirm the immunopresence of kisspeptin and its receptor in the ovary of swine and to study the effects of kisspeptin 10 and its ...
Margherita Maranesi, Massimo Zerani, Giuseppina Basini   +2 more
exaly   +4 more sources

Serum stability of selected decapeptide agonists of KISS1R using pseudopeptides

Bioorganic & Medicinal Chemistry Letters, 2012
Metastin/kisspeptin, a 54-amino acid peptide, is the ligand of the G-protein-coupled receptor KISS1R which plays a key role in pathways that regulate reproduction and cell migration in many endocrine and gonadal tissues. The N-terminally truncated decapeptide, metastin(45-54), has 3-10 times higher receptor affinity and intracellular calcium ion ...
Taiji, Asami, Naoki, Nishizawa, Yoshihiro, Ishibashi, Kimiko, Nishibori, Masaharu, Nakayama, Yasuko, Horikoshi, Shin-ichi, Matsumoto, Masashi, Yamaguchi, Hirokazu, Matsumoto, Naoki, Tarui, Tetsuya, Ohtaki, Chieko, Kitada   +11 more
openaire   +2 more sources

A clinicopathological analysis of KISS1 and KISS1R expression in colorectal cancer

Apmis, 2015
Kisspeptins, the products of the KISS1 gene have tumor suppressing and antimetastatic properties. We aimed to study KISS1 and KISS1R expression in colorectal cancer. We analyzed KISS1 and KISS1R expression using immunohistochemistry and image analysis in
Ioannis Kostakis, Gregory Kouraklis, Michael Koutsilieris   +2 more
exaly   +1 more source

Escitalopram as a modulator of proopiomelanocortin, kisspeptin, Kiss1R and MCHR1 gene expressions in the male rat brain

Molecular Biology Reports, 2020
Neuropeptides are important, multifunctional regulatory factors of the nervous system, being considered as a novel, atypical sites of antidepressants action.
Ryszard Wiaderkiewicz, K Bogus, Łukasz Filipczyk   +2 more
exaly   +1 more source

The role of neuropeptides and neurotransmitters on kisspeptin/kiss1r-signaling in female reproduction

Journal of Chemical Neuroanatomy, 2018
Reproductive function is regulated by the hypothalamic-pituitary-gonads (HPG) axis. Hypothalamic neurons synthesizing kisspeptin play a fundamental role in the central regulation of the timing of puberty onset and reproduction in mammals. Kisspeptin is a regulator of gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH).
Saman Saedi, Arezoo Khoradmehr, Jafarzadeh Shirazi Mohammad Reza, Amin Tamadon   +3 more
openaire   +2 more sources

KISS1/KISS1R SIGNAL SYSTEM AND ITS ROLE IN THE CARCINOGENESIS

Genes & Cells, 2019
The KISS1 / KISS1R signaling system can serve as a regulator of metastasis of tumors and is a potential prognostic marker of tumor processes. The action of kisspeptin10 on the Era-negative non - malignant breast epithelial cells or KISS1R expression in these cells can induce passage to the mesenchymal phenotype and to stimulate the invasiveness.
M. V Mnikhovich, T. V Bezuglova, L. V Kaktursky, K. V Bunkov, A. S Tuchkova, M. I Trifonov, E. S Mishina   +6 more
openaire   +1 more source

Trypsin resistance of a decapeptide KISS1R agonist containing an N-methylarginine substitution

Bioorganic & Medicinal Chemistry Letters, 2012
Metastin/kisspeptin is an amidated peptide with 54 amino acid residues isolated from human placental tissues as a ligand of the orphan G-protein-coupled receptor KISS1R that is expressed throughout the central nervous system and in a variety of endocrine and gonadal tissues. Compared to the full-length metastin protein, the N-terminal truncated peptide
Taiji, Asami, Naoki, Nishizawa, Yoshihiro, Ishibashi, Kimiko, Nishibori, Yasuko, Horikoshi, Hirokazu, Matsumoto, Tetsuya, Ohtaki, Chieko, Kitada   +7 more
openaire   +2 more sources

Modulation of the hypothalamic-pituitary-gonadal axis by selective ligands of the KISS1R.

Current opinion in investigational drugs (London, England : 2000), 2010
The kisspeptin/kisspeptin receptor (KISS1R) system is a critical regulator of reproductive function. The kisspeptins are potent stimulators of the hypothalamic-pituitary-gonadal (HPG) axis via their actions ongonadotropin-releasing hormone. Therefore, kisspeptins represent putative drug targets for the treatment of reproductive diseases. Kisspeptins of
Murphy, Kevin G., Thompson, Emily L.
openaire   +1 more source