Results 171 to 180 of about 2,946 (202)
KISS1R: Hallmarks of an Effective Regulator of the Neuroendocrine Axis [PDF]
Neuroendocrinology, 2015 Kisspeptin (KP) is now well recognized as a potent stimulator of gonadotropin-releasing hormone (GnRH) secretion and thereby a major regulator of the neuroendocrine-reproductive axis. KP signals via KISS1R, a G protein-coupled receptor (GPCR) that activates the G proteins Gα<sub>q/11</sub>. Modulation of the interaction of KP with KISS1R is
Andy V Babwah, Robert P. Millar
exaly +7 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Physiological and Pathological Roles of Locally Expressed Kisspeptin and KISS1R in the Endometrium
Human Reproduction, 2023Abstract Kisspeptins, encoded by the KISS1 gene, are a family of polypeptides that bind the kisspeptin receptor (KISS1R) to perform biological functions. Produced mainly in the hypothalamus, these neuropeptides regulate the pulsatile secretion of GnRH and trigger the hypothalamus–pituitary–gonadal axis.
Li Nie, Jieyu Zhang, Dongzhi Yuan
exaly +3 more sources
Presence and Function of Kisspeptin/KISS1R System in Swine Ovarian Follicles
Theriogenology, 2018Kisspeptin and its receptor KISS1R are involved in the neuroendocrine regulation of mammalian reproduction and their role on follicular development and function can be hypothesized. The present work was designed to confirm the immunopresence of kisspeptin and its receptor in the ovary of swine and to study the effects of kisspeptin 10 and its ...
Margherita Maranesi +2 more
exaly +4 more sources
Changes in Methylation Patterns of Kiss1 and Kiss1r Gene Promoters Across Puberty
Genetics & Epigenetics, 2013 The initiation of mammalian puberty is underpinned by an increase in Kisspeptin (Kiss1) signaling via its receptor (Kiss1r/GPR54) on gonadotropin-releasing hormone (GnRH) neurons. Animals and humans with loss-of-function mutations in Kiss1 or Kiss1r fail to go through puberty.
Jo-Ann Stanton +2 more
exaly +3 more sources
KISS1/KISS1R and Breast Cancer: Metastasis Promoter
Seminars in Reproductive Medicine, 2019AbstractKisspeptins (KPs), peptide products of the kisspeptin-1 (KISS1) gene, are the endogenous ligands for the KISS1 receptor, KISS1R, which is a G protein-coupled receptor. In many human tumors, KISS1 functions as a metastasis-suppressor gene and KISS1/KISS1R signaling has antimetastatic and tumor-suppressor roles. On the contrary, emerging evidence
Stephania, Guzman +4 more
openaire +2 more sources
A Clinicopathological Analysis of KISS1 and KISS1R Expression in Colorectal Cancer
Apmis, 2015 Kisspeptins, the products of the KISS1 gene have tumor suppressing and antimetastatic properties. We aimed to study KISS1 and KISS1R expression in colorectal cancer. We analyzed KISS1 and KISS1R expression using immunohistochemistry and image analysis in
Ioannis D Kostakis +2 more
exaly +2 more sources
Role of the Kiss1/Kiss1r System in the Regulation of Pituitary Cell Function
Molecular and Cellular Endocrinology, 2016Kisspeptin (Kiss1) is an amidated neurohormone that belongs to the RF-amide peptide family, which has a key role in the control of reproduction. Specifically, kisspeptin regulates reproductive events, including puberty and ovulation, primarily by activating the surface receptor Kiss1r (aka GPR54), at hypothalamic gonadotropin-releasing hormone (GnRH ...
Justo P. Castaño +2 more
exaly +3 more sources
Journal of Chemical Neuroanatomy, 2018
Reproductive function is regulated by the hypothalamic-pituitary-gonads (HPG) axis. Hypothalamic neurons synthesizing kisspeptin play a fundamental role in the central regulation of the timing of puberty onset and reproduction in mammals. Kisspeptin is a regulator of gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH).
Saman Saedi +3 more
openaire +2 more sources
Reproductive function is regulated by the hypothalamic-pituitary-gonads (HPG) axis. Hypothalamic neurons synthesizing kisspeptin play a fundamental role in the central regulation of the timing of puberty onset and reproduction in mammals. Kisspeptin is a regulator of gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH).
Saman Saedi +3 more
openaire +2 more sources
Serum stability of selected decapeptide agonists of KISS1R using pseudopeptides
Bioorganic & Medicinal Chemistry Letters, 2012Metastin/kisspeptin, a 54-amino acid peptide, is the ligand of the G-protein-coupled receptor KISS1R which plays a key role in pathways that regulate reproduction and cell migration in many endocrine and gonadal tissues. The N-terminally truncated decapeptide, metastin(45-54), has 3-10 times higher receptor affinity and intracellular calcium ion ...
Taiji, Asami +11 more
openaire +2 more sources
Mutational analysis of KISS1 and KISS1R in idiopathic central precocious puberty
Journal of Pediatric Endocrinology and Metabolism, 2014The genetic background of idiopathic central precocious puberty (ICPP) is not well understood. The genetic activation of pubertal onset is thought to arise from the effect of multiple genes. Familial ICPP has been reported suggesting the existence of monogenic causes of ICPP.
Marina, Krstevska-Konstantinova +6 more
openaire +2 more sources