Results 181 to 190 of about 2,946 (202)

KISS1/KISS1R SIGNAL SYSTEM AND ITS ROLE IN THE CARCINOGENESIS

Genes & Cells, 2019
The KISS1 / KISS1R signaling system can serve as a regulator of metastasis of tumors and is a potential prognostic marker of tumor processes. The action of kisspeptin10 on the Era-negative non - malignant breast epithelial cells or KISS1R expression in these cells can induce passage to the mesenchymal phenotype and to stimulate the invasiveness.
M. V Mnikhovich, T. V Bezuglova, L. V Kaktursky, K. V Bunkov, A. S Tuchkova, M. I Trifonov, E. S Mishina   +6 more
openaire   +1 more source

Trypsin resistance of a decapeptide KISS1R agonist containing an N-methylarginine substitution

Bioorganic & Medicinal Chemistry Letters, 2012
Metastin/kisspeptin is an amidated peptide with 54 amino acid residues isolated from human placental tissues as a ligand of the orphan G-protein-coupled receptor KISS1R that is expressed throughout the central nervous system and in a variety of endocrine and gonadal tissues. Compared to the full-length metastin protein, the N-terminal truncated peptide
Taiji, Asami, Naoki, Nishizawa, Yoshihiro, Ishibashi, Kimiko, Nishibori, Yasuko, Horikoshi, Hirokazu, Matsumoto, Tetsuya, Ohtaki, Chieko, Kitada   +7 more
openaire   +2 more sources

Modulation of the hypothalamic-pituitary-gonadal axis by selective ligands of the KISS1R.

Current opinion in investigational drugs (London, England : 2000), 2010
The kisspeptin/kisspeptin receptor (KISS1R) system is a critical regulator of reproductive function. The kisspeptins are potent stimulators of the hypothalamic-pituitary-gonadal (HPG) axis via their actions ongonadotropin-releasing hormone. Therefore, kisspeptins represent putative drug targets for the treatment of reproductive diseases. Kisspeptins of
Murphy, Kevin G., Thompson, Emily L.
openaire   +1 more source

Structural basis for Kisspeptin-10 selectivity toward KISS1R: computational insights

In Silico Pharmacology
Kisspeptin-10 (KP-10), the bioactive core fragment of kisspeptin neuropeptides, has emerged as a modulator of reward-related behaviors beyond its canonical role in reproductive neuroendocrinology. While behavioral studies indicate that KP-10 promotes impulsive and compulsive-like phenotypes in rodent models, the molecular mechanisms underlying these ...
Maria A. Netesa, Sarng S. Pyurveev, Andrei A. Lebedev, Eugenii R. Bychkov, Ekaterina V. Skorb, Sergey Shityakov, Petr D. Shabanov   +6 more
openaire   +2 more sources

Functional Analysis of the Emerging Roles for the KISS1/KISS1R Signaling Pathway in Cancer Metastasis

Journal of Genetics and Genomics, 2022
Jing Liu, Hiroyuki Inuzuka, Jianping Guo
exaly  

KISS1R Gene

2020
openaire   +1 more source

Lesions of KNDy and Kiss1R Neurons in the Arcuate Nucleus Produce Different Effects on LH Pulse Patterns in Female Sheep

Endocrinology, 2023
Robert L Goodman, Elizabeth C Bowdridge
exaly  

KISS1R And ANKRD31 Cooperate to Enhance Leydig Cell Gene Expression via the Cytoskeletal-Nucleoskeletal Pathway

Frontiers in Cell and Developmental Biology, 2022
Gilda Cobellis, Riccardo Pierantoni, Teresa Chioccarelli   +2 more
exaly  

KISS1R Signaling Promotes Invadopodia Formation in Human Breast Cancer Cell via β-arrestin2/ERK

Cellular Signalling, 2016
Andy V Babwah, Eva A Turley, Bhattacharya, Moshmi   +2 more
exaly  

β-Arrestin Mediates the Desensitization and Internalization of KISS1R

2011
Maryse Ahow, Neerja Sharma, Christine Glidewell-Kenney, Macarena Pampillo, Douglas Fraser, Pamela L Mellon, Andy V Babwah   +6 more
openaire   +1 more source