Results 41 to 50 of about 16,602 (265)

Timing of maternal exposure and fetal sex determine the effects of low-level chemical mixture exposure on the fetal neuroendocrine system in sheep [PDF]

, 2016
We have shown that continuous maternal exposure to the complex mixture of environmental chemicals (ECs) found in human biosolids (sewage sludge), disrupts mRNA expression of genes crucial for development and long-term regulation of hypothalamo-pituitary ...
Bellingham, M., Cotinot, C., Evans, N.P., Fowler, P.A., MacDonald, E.S., Mandon-Pepin, B., Rhind, S., Sharpe, R.M.   +7 more
core   +2 more sources

Kisspeptin and Testicular Function—Is It Necessary? [PDF]

International Journal of Molecular Sciences, 2020
The role of kisspeptin in stimulating hypothalamic GnRH is undisputed. However, the role of kisspeptin signaling in testicular function is less clear. The testes are essential for male reproduction through their functions of spermatogenesis and steroidogenesis.
Aditi Sharma, Thilipan Thaventhiran, Suks Minhas, Waljit S. Dhillo, Channa N. Jayasena   +4 more
openaire   +5 more sources

The Role of Kisspeptin in the Control of the Hypothalamic-Pituitary-Gonadal Axis and Reproduction

Frontiers in Endocrinology, 2022
The discovery of kisspeptin as a critical central regulatory factor of GnRH release has given people a novel understanding of the neuroendocrine regulation in human reproduction.
Qinying Xie, Yafei Kang, Chenlu Zhang, Ye Xie, Chuxiong Wang, Jiang Liu, Caiqian Yu, Hu Zhao, Donghui Huang   +8 more
doaj   +1 more source

Conditional kisspeptin neuron-specific Kiss1 knockout with newly generated Kiss1-floxed and Kiss1-Cre mice replicates a hypogonadal phenotype of global Kiss1 knockout mice

The Journal of Reproduction and Development, 2020
The present study aimed to evaluate whether novel conditional kisspeptin neuron-specific Kiss1 knockout (KO) mice utilizing the Cre-loxP system could recapitulate the infertility of global Kiss1 KO models, thereby providing further evidence for the ...
Kana IKEGAMI, Teppei GOTO, Sho NAKAMURA, Youki WATANABE, Arisa SUGIMOTO, Sutisa MAJARUNE, Kei HORIHATA, Mayuko NAGAE, Junko TOMIKAWA, Takuya IMAMURA, Makoto SANBO, Masumi HIRABAYASHI, Naoko INOUE, Kei-ichiro MAEDA, Hiroko TSUKAMURA, Yoshihisa UENOYAMA   +15 more
doaj   +1 more source

Role of Kisspeptin and Neurokinin B in Puberty in Female Non-Human Primates

Frontiers in Endocrinology, 2018
In human patients, loss-of-function mutations in the genes encoding kisspeptin (KISS1) and neurokinin B (NKB) and their receptors (KISS1R and NK3R, respectively) result in an abnormal timing of puberty or the absence of puberty.
Ei Terasawa, Ei Terasawa, James P. Garcia, Stephanie B. Seminara, Kim L. Keen   +4 more
doaj   +1 more source

Receptor deorphanization in an echinoderm reveals kisspeptin evolution and relationship with SALMFamide neuropeptides

BMC Biology, 2022
Background Kisspeptins are neuropeptides that regulate reproductive maturation in mammals via G-protein-coupled receptor-mediated stimulation of gonadotropin-releasing hormone secretion from the hypothalamus.
Nayeli Escudero Castelán, Dean C. Semmens, Luis Alfonso Yañez Guerra, Meet Zandawala, Mario dos Reis, Susan E. Slade, James H. Scrivens, Cleidiane G. Zampronio, Alexandra M. Jones, Olivier Mirabeau, Maurice R. Elphick   +10 more
doaj   +1 more source

Effect of Peripheral Administration of Kisspeptin-10 on Dynamic LH Secretion in Prepubertal Ewes [PDF]

Asian-Australasian Journal of Animal Sciences, 2012
The aim of the present study was to clarify the effect of kisspeptin-10 on LH secretion in prepubertal ewes. In experiment 1, prepubertal ewes fitted with indwelling jugular catheters were randomly assigned to receive 0, 0.5, 1 or 2 mg of kisspeptin-10 ...
Jun Wang, Lei Sun, Tao Zhang, Haizhu Zhou, Yujie Lou   +4 more
doaj   +1 more source

Mutual interaction of kisspeptin, estrogen and bone morphogenetic protein-4 activity in GnRH regulation by GT1-7 cells [PDF]

, 2013
Reproduction is integrated by interaction of neural and hormonal signals converging on hypothalamic neurons for controlling gonadotropin-releasing hormone (GnRH).
Glidewell-Kenney, Christine, Inagaki, Kenichi, Lawson, Mark A., Makino, Hirofumi, Nakamura, Eri, Ogura-Ochi, Kanako, Otsuka, Fumio, Terasaka, Tomohiro, Toma, Kishio, Tsukamoto, Naoko   +9 more
core   +1 more source

Pacemaking kisspeptin neurons [PDF]

Experimental Physiology, 2013
New findings What is the topic for this review?This review focuses on analysis of the electrophysiological properties of hypothalamic kisspeptin neurons. What advances does it highlight?Molecular and cellular electrophysiological analysis of kisspeptin neurons reveals that they express the critical pacemaker channels for generating burst‐firing ...
Martin J. Kelly, Chunguang Zhang, Oline K. Rønnekleiv, Jian Qiu   +3 more
openaire   +3 more sources

Seasonal Variation in the Gonadotropin-Releasing Hormone Response to Kisspeptin in Sheep: Possible Kisspeptin Regulation of the Kisspeptin Receptor [PDF]

Neuroendocrinology, 2012
Kisspeptin signaling in the hypothalamus appears critical for the onset of puberty and driving the reproductive axis. In sheep, reproduction is seasonal, being activated by short days and inhibited by long days. During the non-breeding (anestrous) season, gonadotropin-releasing hormone (GnRH) and gonadotropin secretion is reduced, as is the expression ...
Alexandra Roa, Jeremy Troy Smith, Qun Li, Iain J. Clarke   +3 more
openaire   +3 more sources