Results 41 to 50 of about 21,456 (303)

Neuroendocrine Regulation of Stress‐Induced T Cell Dysfunction during Lung Cancer Immunosurveillance via the Kisspeptin/GPR54 Signaling Pathway

Advancement of science, 2022
Emerging evidence suggests that physiological distress is highly correlated with cancer incidence and mortality. However, the mechanisms underlying psychological challenges‐mediated tumor immune evasion are not systematically explored.
Su Zhang, Fangfei Yu, Anran Che, Binghe Tan, Chenshen Huang, Yuxue Chen, Xiaohong Liu, Qi Huang, Wenying Zhang, Chengbin Ma, M. Qian, Mingyao Liu, Juliang Qin, Bing Du   +13 more
semanticscholar   +1 more source

The Correlation between Hormonal Disturbance in PCOS Women and Serum Level of Kisspeptin

International Journal of Endocrinology, 2020
Background. Kisspeptin is a neuropeptide that upregulates gonadotropin-releasing hormone (GnRH) secretion. It is an essential element for the luteinizing hormone (LH) surge and ovulation.
Razaw O. Ibrahim, Shirwan H. Omer, Chro N. Fattah   +2 more
doaj   +1 more source

Targeting hepatic kisspeptin receptor ameliorates nonalcoholic fatty liver disease in a mouse model

Journal of Clinical Investigation, 2022
Nonalcoholic fatty liver disease (NAFLD), the most common liver disease, has become a silent worldwide pandemic. The incidence of NAFLD correlates with the rise in obesity, type 2 diabetes, and metabolic syndrome.
Stephania Guzman, M. Drăgan, H. Kwon, Vanessa de Oliveira, Shi-Tao Rao, V. Bhatt, K. Kalemba, Ankit M. Shah, V. Rustgi, Heng Wang, P. Bech, A. Abbara, C. Izzi-Engbeaya, P. Manousou, J. Y. Guo, G. Guo, S. Radovick, W. Dhillo, F. Wondisford, A. Babwah, M. Bhattacharya   +20 more
semanticscholar   +1 more source

Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54

Proceedings of the National Academy of Sciences of the United States of America, 2005
Alan G Hendrick, Didier Lomet, Samuel A J R Aparicio   +2 more
exaly   +2 more sources

Investigating the KNDy hypothesis in humans by co-administration of kisspeptin, neurokinin B and naltrexone in men [PDF]

, 2016
Context: A subpopulation of hypothalamic neurons co-localise three neuropeptides namely kisspeptin, neurokinin B (NKB) and dynorphin collectively termed KNDy neurons. Animal studies suggest they interact to affect pulsatile GnRH release (KNDy hypothesis);
Abbara, A, Bassett, P, Bloom, S, COMNINOS, A, Dhillo, WS, Jayasena, C, Mizamtsidi, M, Narayanaswamy, S, Papadopoulou, D, Prague, J, Shah, A, Veldhuis, J   +11 more
core   +1 more source

Transcriptome profiling of kisspeptin neurons from the mouse arcuate nucleus reveals new mechanisms in estrogenic control of fertility

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance The arcuate nucleus (ARC) of the mediobasal hypothalamus is critically involved in hormonal communication from ovary to brain. Negative estrogen feedback to kisspeptin synthesizing neurons of the ARC is a crucial determinant of hypothalamic ...
Balázs Göcz, Éva Rumpler, M. Sárvári, K. Skrapits, Szabolcs Takács, I. Farkas, Veronika Csillag, Sarolta H Trinh, Zsuzsanna Bardóczi, Yvette Ruska, N. Solymosi, S. Póliska, Zsuzsanna Szőke, L. Bartoloni, Y. Zouaghi, A. Messina, N. Pitteloud, Ross C. Anderson, R. Millar, R. Quinton, Stephen M. Manchishi, W. Colledge, E. Hrabovszky   +22 more
semanticscholar   +1 more source

The Effects of 5-Hydroxytryptamine and Interaction With Kisspeptin in Controlling Ghrelin and Adiponectin Secretion [PDF]

International Journal of Basic Science in Medicine, 2022
Introduction: 5-Hydroxytryptamine (5HT) and kisspeptin are satiety factors, and ghrelin and adiponectin are orexigenic peptides. In this study, the mediating role of 5HT in the effects of GPR54 receptor blocking on ghrelin and adiponectin secretion was ...
Maryam Kamvar, Fariba Mahmoudi, Fatemeh Mohammadzadeh, Homayoun Khazali, Abolfazl Bayrami   +4 more
doaj   +1 more source

Kisspeptin Overcomes GnRH Neuronal Suppression Secondary to Hyperprolactinemia in Humans

Journal of Clinical Endocrinology and Metabolism, 2022
Context Hyperprolactinemia suppresses gonadotropin-releasing hormone (GnRH)-induced luteinizing hormone (LH) pulses. The hypothalamic neuropeptide kisspeptin potently stimulates the secretion of GnRH. The effects of exogenous kisspeptin administration on
Kateřina Hošková, N. Bryant, Margaret E. Chen, L. Nachtigall, Margaret F. Lippincott, Ravikumar Balasubramanian, S. Seminara   +6 more
semanticscholar   +1 more source

The Role of the Brain in the Pathogenesis and Physiology of Polycystic Ovary Syndrome (PCOS). [PDF]

, 2019
Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder, affecting at least 10% of women of reproductive age. PCOS is typically characterized by the presence of at least two of the three cardinal features of hyperandrogenemia (high ...
Coutinho, Eulalia A, Kauffman, Alexander S   +1 more
core   +1 more source

Opioidergic pathways and kisspeptin in the regulation of female reproduction in mammals

Frontiers in Neuroscience, 2022
Endogenous opioid peptides have attracted attention as critical neuropeptides in the central mechanism regulating female reproduction ever since the discovery that arcuate dynorphin neurons that coexpress kisspeptin and neurokinin B (NKB), which are also
Y. Uenoyama, Hitomi Tsuchida, Mayuko Nagae, Naoko Inoue, H. Tsukamura   +4 more
semanticscholar   +1 more source