Results 1 to 10 of about 5,745 (144)
Lactylated SPTAN1 Accelerates Hepatocellular Carcinoma Progression by Promoting NOTCH1/HES1 Activation and Immunosuppression [PDF]
Advanced ScienceNonerythrocytic alphaII‐spectrin (SPTAN1) is crucial for neuronal functions, yet its role in oncogenic processes remains inadequately characterized. This study investigates the lactylation (kla) modification of SPTAN1 (SPTAN1‐kla) and its mechanistic ...
Zengbin Wang +8 more
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kLa MEASUREMENT IN BIOREACTORS
Chemical Engineering Transactions, 2010 preview not available - see full-text PDF article.
F. Scargiali +3 more
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Nano-Engineered Delivery of the Pro-Apoptotic KLA Peptide: Strategies, Synergies, and Future Directions [PDF]
BiomoleculesAntimicrobial peptides have been increasingly recognized as potential anticancer agents, with the KLA peptide (KLAKLAK2) being one of the most well-known and successful examples.
Yunmi Cho, Ha Gyeong Kim, Eun-Taex Oh
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Lysine lactylation in diseases: beyond histone lactylation [PDF]
Cell Death and DiseaseLactylation, a recently identified post-translational modification, was initially characterized as lysine residue modification in histone subunits that regulates gene transcription via epigenetic mechanisms.
Yiming Liu +6 more
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ESM1 and protein lysine L-lactylation modification (Pan-kla) in ovarian cancer: coexpression, clinical significance, and prognostic value [PDF]
Diagnostic PathologyBackground Ovarian cancer (OC) remains a highly lethal gynaecologic malignancy. Endothelial cell-specific molecule 1 (ESM1) and protein lysine L-lactylation modification (Pan-kla) are key players in tumour microenvironment regulation, which involves ...
Wenchao Zhou +6 more
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Metabolites, 2023 Protein lysine lactylation (Kla) is a novel protein acylation reported in recent years, which plays an important role in the development of several diseases with pathologically elevated lactate levels, such as tumors.
Wenhua Huang +7 more
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Identification of lysine-lactylated substrates in gastric cancer cells
iScience, 2022 Summary: Cancer cells tend to utilize aerobic glycolysis to generate energy and metabolites; the end product of aerobic glycolysis is lactate, which promotes lysine lactylation (Kla). Kla is a newly discovered histone post-translational modification (PTM)
Dawei Yang +5 more
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Proceedings of the 23rd international conference on Parallel architectures and compilation, 2014 This paper proposes a new algorithmic paradigm — k-level asynchronous (KLA) — that bridges level-synchronous and asynchronous paradigms for processing graphs. The KLA paradigm enables the level of asynchrony in parallel graph algorithms to be parametrically varied from none (level-synchronous) to full (asynchronous).
null Harshvardhan +3 more
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Lysine lactylation (Kla) might be a novel therapeutic target for breast cancer
BMC Medical Genomics, 2023 Background Histone lysine lactylation (Kla) is a newly identified histone modification, which plays a crucial role in cancer progression. Hence, we determined the prognostic value of Kla in breast cancer (BC).
Jian Deng, Xinyi Liao
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FSL-Kla: A few-shot learning-based multi-feature hybrid system for lactylation site prediction
Computational and Structural Biotechnology Journal, 2021 As a novel lactate-derived post-translational modification (PTM), lysine lactylation (Kla) is involved in diverse biological processes, and participates in human tumorigenesis.
Peiran Jiang +7 more
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