Recent Advances of Lysine Lactylation in Prokaryotes and Eukaryotes [PDF]
Frontiers in Molecular BiosciencesLysine lactylation is a newly discovered protein post-translational modification that plays regulatory roles in cell metabolism, growth, reprogramming, and tumor progression.
Zhao Wenjuan, Zhifang Li
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Lactate and Lysine Lactylation of Histone Regulate Transcription in Cancer [PDF]
HeliyonHistone lysine modifications were well-established epigenetic markers, with many types identified and extensively studied. The discovery of histone lysine lactylation had revealed a new form of epigenetic modification.
Yin Ku, Zhipeng Gong, Wenjing Zhou
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Lysine lactylation in neutrophil functional remodeling across diverse disease contexts [PDF]
Frontiers in ImmunologyLactate, traditionally regarded as a product of glycolytic metabolism, is increasingly recognized as a metabolite that can influence cellular signaling and protein post-translational modification, including lysine lactylation (Kla).
Yushu Wang +5 more
doaj +2 more sources
Protein Lysine Lactylation in DNA Damage Response: Regulatory Mechanisms and Emerging Functions [PDF]
BiomoleculesGenomic DNA is constantly exposed to endogenous and exogenous stresses that can cause different types of DNA damage. DNA double-strand breaks (DSBs) are among the most damaging forms of DNA lesions, as persistent breaks can compromise genome stability ...
Xinke Pei +10 more
doaj +2 more sources
Lysine lactylation regulates ATF4-mediated stress responses under glucose starvation in canine hemangiosarcoma [PDF]
Frontiers in Veterinary ScienceExcess lactate is produced in tumor cells by aerobic glycolysis and regulates gene expressions by histone lactylation. However, how histone lactylation functions under glucose-limited conditions remains unknown.
Tamami Suzuki +21 more
doaj +2 more sources
First Lysine Lactylation Profiling in Vibrio alginolyticus and Initial Characterization of VaCobQ as a Candidate Delactylase [PDF]
MicroorganismsVibrio alginolyticus is a common pathogenic bacterium and can cause diseases in aquaculture animals. Lysine lactylation (Kla) is a novel post-translational modification (PTM) that has been confirmed to play critical roles in key biological processes ...
Yujia Zhang +8 more
doaj +2 more sources
Lysine lactylation in diseases: beyond histone lactylation [PDF]
Cell Death and DiseaseLactylation, a recently identified post-translational modification, was initially characterized as lysine residue modification in histone subunits that regulates gene transcription via epigenetic mechanisms.
Yiming Liu +6 more
doaj +2 more sources
Deciphering novel enzymatic and non-enzymatic lysine lactylation in Salmonella [PDF]
Emerging Microbes and InfectionsLysine lactylation, a novel post-translational modification, is involved in multiple cellular processes. The role of lactylation remains largely unknown, especially in bacteria.
Chuanzhen Zhang +8 more
doaj +2 more sources
Sirt5 preserves mitochondrial homeostasis to improve cardiac function in ischemia-reperfusion injury by inhibiting ANT2 lysine lactylation modification [PDF]
Cellular and Molecular Life SciencesMyocardial ischemia-reperfusion (IR) injury, a prevalent heart disease, disrupts mitochondrial homeostasis, affecting heart energy metabolism. The role of mitochondrial protein Sirt5 in protecting the heart from IR injury is explored in mice.
Simeng Li +11 more
doaj +2 more sources
Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation in Asthenozoospermia [PDF]
Molecular and Cellular ProteomicsXuejiang Guo, Yueshuai Guo, Xianlin Xu
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