Results 31 to 40 of about 119,118 (204)

Lactate-Mediated Lysine Lactylation in Renal Fibrosis: Current Progress and Challenges. [PDF]

FASEB J
ABSTRACT Renal fibrosis constitutes the core pathological hallmark of chronic kidney disease (CKD) progression. Its intricate pathogenesis and the paucity of efficacious clinical interventions have elevated it to a critical global public health concern.
Wang W, Xu K, Xu Y, Ge X, Lv Y.
europepmc   +3 more sources

Systematic analysis of lysine lactylation in nucleus pulposus cells. [PDF]

iScience
Nucleus pulposus (NP) resides in hypoxic microenvironment and NP cells (NPCs), primarily reply on glycolysis and producing high levels of lactate. Intracellular lactate drives lysine lactylation (Kla) as a newly epigenetic modification. However, the impact of Kla on NPCs remains unknown.
Sheng L, Xu H, Wang Y, Ni J, Xiang T, Xu H, Zhou X, Wei K, Dai J.   +8 more
europepmc   +4 more sources

Identification of lysine-lactylated substrates in gastric cancer cells

iScience, 2022
Cancer cells tend to utilize aerobic glycolysis to generate energy and metabolites; the end product of aerobic glycolysis is lactate, which promotes lysine lactylation (Kla). Kla is a newly discovered histone post-translational modification (PTM) that plays important roles in regulating gene expression. However, Kla in non-histone mammalian proteins is
Dawei Yang, Jie Yin, Liuqun Shan, Xingling Yi, Wei Zhang, Yongbin Ding   +5 more
openaire   +3 more sources

Lysine lactylation (Kla) might be a novel therapeutic target for breast cancer. [PDF]

BMC Med Genomics, 2023
Abstract Background Histone lysine lactylation (Kla) is a newly identified histone modification, which plays a crucial role in cancer progression. Hence, we determined the prognostic value of Kla in breast cancer (BC). Methods We obtained RNA expression profiles of BC from ...
Deng J, Liao X.
europepmc   +4 more sources

PBertKla: a protein large language model for predicting human lysine lactylation sites. [PDF]

BMC Biol
Background Lactylation is a newly discovered type of post-translational modification, primarily occurring on lysine (K) residues of both histones and non-histones to exert diverse effects on target proteins.
Lai H, Luo D, Yang M, Zhu T, Yang H, Luo X, Wei Y, Xie S, Hong F, Shu K, Dao F, Ding H.   +11 more
europepmc   +2 more sources

Role of lysine lactylation in neoplastic and inflammatory pulmonary diseases (Review). [PDF]

Int J Mol Med
Protein lysine lactylation is a ubiquitous and post‑translational modification of lysine residues that involves the addition of a lactyl group on both histone and non‑histone proteins. This process plays a pivotal role in human health and disease and was first discovered in 2019.
Wang S, Zheng H, Zhao J, Xie J.
europepmc   +3 more sources

Additional file 1 of High-intensity interval training induces lactylation of fatty acid synthase to inhibit lipid synthesis

, 2023
Additional file 1: Fig. S1. HIIT and DCA injection change the plasma fatty acid content and lipid metabolism in iWAT. Fig. S2. HIIT promotes protein lactylation in different tissues. Fig. S3. Supplement detection and profile of lysine lactylation in mice
Wenhua Huang (308204), Hongfeng Jiang (131042), Zheng Xing (335154), Xuefei Chen (470026), Jing Zhang (17010535), Yanjun Li (46396), Jingbo Zhang (326042), Lanlan Guo (3940025)   +7 more
core   +1 more source

Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells

iScience
Summary: Aerobic glycolysis is a pivotal hallmark of cancers, including colorectal cancer. Evidence shows glycolytic enzymes are regulated by post-translational modifications (PTMs), thereby affecting the Warburg effect and reprograming cancer metabolism.
Zhe Cheng, Huichao Huang, Maoyu Li, Yongheng Chen   +3 more
doaj   +1 more source

Infection-induced lysine lactylation enables herpesvirus immune evasion. [PDF]

Sci Adv
Aerobic glycolysis is a hallmark of many viral infections, leading to substantial accumulation of lactate. However, the regulatory roles of lactate during viral infections remain poorly understood. Here, we report that human cytomegalovirus (HCMV) infection leverages lactate to induce widespread protein lactylation and promote viral spread.
Tyl MD, Merengwa VU, Cristea IM.
europepmc   +3 more sources

Global Profiling of Lysine Acetylation and Lactylation in Kupffer Cells

Among the various cell types that constitute the liver, Kupffer cells (KCs) are responsible for the elimination of gut-derived foreign products. Protein lysine acetylation (Kac) and lactylation (Kla) are dynamic and reversible post-translational ...
Young-Chang Cho (3202704), Eunji Sung (1471240), Sangkyu Lee (228641), Minjia Tan (629800), Wonhwa Lee (1474690), Hyunchae Sim (10984419), Jong-Sup Bae (1443424)   +6 more
core   +5 more sources