Results 41 to 50 of about 119,118 (204)

Epigenetic regulation of cardiac tissue development by lysine lactylation. [PDF]

Hlife
Luan X, Du R, Su G, Yan C, Ren X, Ju K, Jin Y, An Y, Guo D, Tian Z, Huang H, Zhang S.   +11 more
europepmc   +2 more sources

Research progress and prospect of histone lactylation in digestive system tumors [PDF]

Zhongguo aizheng zazhi
Histone lactylation is a novel type of post-translational modification, where a lactate molecule covalently binds to the lysine residues of histones. This modification plays a key role in cellular metabolic reprogramming, particularly in digestive system
ZENG Dandan, LUO Wenfeng, YE Jiazhou, LIN Yan, LIANG Rong
doaj   +3 more sources

Lysine Lactylation of Hemoglobin Promotes Oxygen Release in Red Blood Cells. [PDF]

ACS Omega
Hemoglobin oxygen affinity (HOA) increases during the storage of red blood cells (RBCs), which hinders the oxygen-release efficacy after transfusion. RBCs stored in alkaline preservation solution promote glycolysis and its final product lactate, which is an allosteric regulator of HOA.
Sheng M, Jin H, Tao S, You G, Li W, Chang C, Wang Y, Zhao L, Zhou H.   +8 more
europepmc   +4 more sources

p300‐Mediated H3K18 Lactylation Drives Radiation‐Induced Pulmonary Fibrosis via VIRMA‐Dependent m6A Modification of GATA3

Advanced Science, EarlyView.
Radiation triggers glycolytic reprogramming in alveolar epithelial type II cells, causing pathological lactate accumulation. This metabolic stress drives p300‐mediated H3K18 lactylation at the VIRMA promoter, activating transcription. Elevated VIRMA enriches m6A on GATA3 mRNA, which YTHDF1 stabilizes, ultimately driving epithelial–mesenchymal ...
Junxuan Yi, Mingwei Wang, Duo Yu, Mingqi Zhao, Xinyan Wang, Shiqi Li, Xiaowen Han, Wei Wei, Shunzi Jin   +8 more
wiley   +1 more source

Protein lactylation in kidney diseases

Frontiers in Cell and Developmental Biology
Post-translational modifications (PTMs) regulate protein function and structure through covalent modifications, participating in various physiological and pathological processes.
Yelei Xu, Xinming Li, Xinming Li, Zhiguo Mao, Cheng Xue   +4 more
doaj   +1 more source

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

DLST Succinylation‐Mediated Mitochondrial Metabolic Remodeling and Cuproptosis Resistance Promote Malignant Progression of Lung Adenocarcinoma

Advanced Science, EarlyView.
The DLST K409 succinylation mediated by CPT1A promotes OXPHOS and redox homeostasis through regulating enzyme activity, thereby promoting the malignant progression of LUAD. Notably, the succinylation of DLST can enhance the cuproptosis resistance by inhibiting its lipoylation.
Xuanxuan Li, Peijun Zhou, Xingzhi Peng, Qixin Liu, Wenhui Zeng, Rui Wang, Liangfang Shen, Jinwu Peng, Qin Zhou, Lifang Yang   +9 more
wiley   +1 more source

HAT1 functions as a lactyltransferase and mediates RPA1 lactylation to promote DNA repair and radioresistance in lung adenocarcinoma

Cell Death and Disease
Lysine lactylation is a post-translational modification induced by lactate discovered in recent years. Abnormal lysine lactylation contributes to the occurrence and progression of various tumors.
Jiang He, Tangmin Lai, Yuzu Zhao, Zhiying Zhou, Liu Zhou, Dan Tao, Haonan Yang, Nan Li, Yu He, Shuheng Yang, Zheng Tang, Siwei Zeng, Erha Munai, Yanchen Liu, Yuanyuan Tan, Wei Zhou, Yongzhong Wu   +16 more
doaj   +1 more source

Protein Lactylation: A new jewel in the crown

Asian Journal of Medical Sciences
Lactylation is a newly identified post-translational modification that has emerged as a crucial epigenetic regulator, significantly influencing cellular functions and disease processes. Lactylation involves the addition of lactate, a glycolysis byproduct,
Ruby Dhar , Arun Kumar , Subhradip Karmakar   +2 more
doaj   +1 more source

Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model. [PDF]

Front Cell Dev Biol
IntroductionKawasaki disease (KD) is a medium-vessel vasculitis predominantly affecting children under 5 years of age and may involve the coronary arteries.MethodsA mouse KD model was induced by Candida albicans cell wall extracts (CAWS), cardiac tissues were analyzed through integrated lactylomic and proteomic profiling.
Zhuo W, Zhang M, Tan J, Gao Y, Wang Y, Wang N, Ma J, Zhang J, Liu Z, Lv H, Liu Y.   +10 more
europepmc   +4 more sources