Results 21 to 30 of about 119,118 (204)

Oxygen Glucose Deprivation-Induced Lactylation of H3K9 Contributes to M1 Polarization and Inflammation of Microglia Through TNF Pathway

Biomedicines
Background: Hypoxia-induced M1 polarization of microglia and resultant inflammation take part in the damage caused by hypoxic-ischemic encephalopathy (HIE).
Lu He, Rui Yin, Weijian Hang, Jinli Han, Juan Chen, Bin Wen, Ling Chen   +6 more
doaj   +2 more sources

MeCP2 Lactylation Protects against Ischemic Brain Injury by Transcriptionally Regulating Neuronal Apoptosis

Advanced Science
Lactate plays diverse roles in brain pathophysiology, including ischemic stroke. Here, the role of lysine lactylation, an epigenetic modification of lactate, in cerebral ischemia is investigated.
Min Sun, Yuxin Zhang, Rui Mao, Yan Chen, Pinyi Liu, Lei Ye, Siyi Xu, Junqiu Jia, Shu Shu, Huiya Li, Yanping Yin, Shengnan Xia, Yanting Chen, Yun Xu   +13 more
doaj   +2 more sources

Comprehensive analysis of lysine lactylation in Frankliniella occidentalis. [PDF]

Front Genet, 2022
Western flower thrips (Frankliniella occidentalis) are among the most important pests globally that transmit destructive plant viruses and infest multiple commercial crops. Lysine lactylation (Klac) is a recently discovered novel post-translational modification (PTM).
An D, Song L, Li Y, Shen L, Miao P, Wang Y, Liu D, Jiang L, Wang F, Yang J.   +9 more
europepmc   +4 more sources

Histone Lactylation as an Epigenetic Regulator in Alzheimer’s Disease Pathophysiology: A Narrative Review

Journal of Inflammation Research
Jingkai Tang,1,* Yiwei Zhang,1,* Yibing Wang,1,* Yanxin Fu,1 Jingman Qi,1 Aomeng Xiang,1 Ruoxuan Zhao,1 Ge Tan,1 Huili Deng,2 Xuchang Zhou,2 Liang Wu3 1Department of Sport Rehabilitation, Tianjin University of Sport, Tianjin ...
Tang J, Zhang Y, Wang Y, Fu Y, Qi J, Xiang A, Zhao R, Tan G, Deng H, Zhou X, Wu L   +10 more
doaj   +1 more source

YiaC and CobB regulate lysine lactylation in Escherichia coli. [PDF]

Nat Commun, 2022
Abstract Lysine lactylation (Kla) has recently been reported to participate in regulating transcription in human cells. However, the characterization, regulatory mechanism and functional consequence of Kla in prokaryotes remain unclear. Here, we report that YiaC functions as a lysine lactylase and that CobB serves
Dong H, Zhang J, Zhang H, Han Y, Lu C, Chen C, Tan X, Wang S, Bai X, Zhai G, Tian S, Zhang T, Cheng Z, Li E, Xu L, Zhang K.   +15 more
europepmc   +4 more sources

The TRIM33 Bromodomain Recognizes Histone Lysine Lactylation. [PDF]

ACS Chem Biol
Histone lysine lactylation (Kla) regulates inflammatory gene expression in activated macrophages and mediates the polarization of inflammatory (M1) to reparative (M2) macrophages. However, the molecular mechanisms and key protein players involved in Kla-mediated transcriptional changes are unknown.
Nuñez R, Sidlowski PFW, Steen EA, Wynia-Smith SL, Sprague DJ, Keyes RF, Smith BC.   +6 more
europepmc   +3 more sources

Global profiling of lysine lactylation in human lungs

PROTEOMICS, 2023
AbstractLactate is closely related to various cellular processes, such as angiogenesis, responses to hypoxia, and macrophage polarization, while regulating natural immune signaling pathways and promoting neurogenesis and cognitive function. Lysine lactylation (Kla) is a novel posttranslational modification, the examination of which may lead to new ...
Ye‐Hong Yang, Qiao‐Chu Wang, Jie Kong, Jun‐Tao Yang, Jiang‐Feng Liu   +4 more
openaire   +2 more sources

Global Profiling of Lysine Lactylation in Prostate Cancer Cells. [PDF]

Cancer Genomics Proteomics
Lysine lactylation (Kla) is a recently identified post-translational modification derived from lactate that regulates diverse biological processes. Although Kla has been studied in several cancers, its role in prostate cancer (PC) remains unclear. The objective of this study is to profile Kla in PC in order to explore the mechanisms involved in PC ...
Kim JY, Sim H, Na AY, Choi SY, Lee S.
europepmc   +3 more sources

Systematic identification of the lysine lactylation in the protozoan parasite Toxoplasma gondii. [PDF]

Parasit Vectors, 2022
Abstract Background Lysine lactylation (Kla) is a novelposttranslational modification (PTM) identified in histone and nonhistone proteins of several eukaryotic cells that directly activates gene expression and DNA replication.
Zhao W, Yu H, Liu X, Wang T, Yao Y, Zhou Q, Zheng X, Tan F.   +7 more
europepmc   +4 more sources

Protein Lactylation Critically Regulates Energy Metabolism in the Protozoan Parasite Trypanosoma brucei

Frontiers in Cell and Developmental Biology, 2021
Lysine lactylation has been recognized as a novel post-translational modification occurring on histones. However, lactylation in non-histone proteins, especially in proteins of early branching organisms, is not well understood.
Naiwen Zhang, Naiwen Zhang, Ning Jiang, Ning Jiang, Liying Yu, Liying Yu, Tiandong Guan, Tiandong Guan, Xiaoyu Sang, Xiaoyu Sang, Ying Feng, Ying Feng, Ran Chen, Ran Chen, Qijun Chen, Qijun Chen   +15 more
doaj   +1 more source