Results 11 to 20 of about 119,118 (204)

Global Analysis of Lysine Lactylation of Germinated Seeds in Wheat. [PDF]

Int J Mol Sci, 2023
Protein lactylation is a newly discovered posttranslational modification (PTM) and is involved in multiple biological processes, both in mammalian cells and rice grains. However, the function of lysine lactylation remains unexplored in wheat. In this study, we performed the first comparative proteomes and lysine lactylomes during seed germination of ...
Zhu J, Guo W, Lan Y.
europepmc   +4 more sources

Class I Histone Deacetylases Catalyze Lysine Lactylation [PDF]

Journal of Biological Chemistry
Abstract Metabolism and post-translational modifications (PTMs) are intrinsically linked and the number of identified metabolites that can covalently modify proteins continues to increase. This metabolism/PTM crosstalk is especially true for lactate, the product of anaerobic metabolism following glycolysis.
Nathaniel Snyder, George M. Burslem, Emily Goldberg   +2 more
exaly   +6 more sources

Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis

Nature Chemical Biology
Abstract Lysine l -lactylation (K l -la ) is a novel protein posttranslational modification (PTM) driven by l -lactate.
Di Zhang, Jinjun Gao, Zhijun Zhu, Qianying Mao, Zhiqiang Xu, Pankaj K. Singh, Cornelius C. Rimayi, Carlos Moreno-Yruela, Shuling Xu, Gongyu Li, Yi-Cheng Sin, Yue Chen, Christian A. Olsen, Nathaniel W. Snyder, Lunzhi Dai, Lingjun Li, Yingming Zhao   +16 more
openaire   +5 more sources

The Oncogenic Regulation of Histone Lysine Lactylation [PDF]

, 2021
L-lactate is generated during glycolysis, a metabolic pathway that is widely associated with many physiological and disease related processes. We recently reported the discovery of lysine L-lactylation [K(L-la)] as a novel protein posttranslational modification occurring on histone proteins that can contribute to gene transcription.
Perez-Neut, Mathew
openaire   +2 more sources

Serpina3k lactylation protects from cardiac ischemia reperfusion injury

Nature Communications
Lactate produced during ischemia-reperfusion injury is known to promote lactylation of proteins, which play controversial roles. By analyzing the lactylomes and proteomes of mouse myocardium during ischemia-reperfusion injury using mass spectrometry, we ...
Le Wang, Dandan Li, Fang Yao, Shanshan Feng, Chao Tong, Rongjia Rao, Meiyan Zhong, Xianqiang Wang, Wei Feng, Zhan Hu, Bo Jin, Li Wang, Shengshou Hu, Bingying Zhou   +13 more
doaj   +2 more sources

Protein lactylation: a metabolic signal driving cancer therapy resistance

Cell Death Discovery
Unlike normal cells, which primarily rely on oxidative phosphorylation, cancer cells reprogram their metabolism by preferentially utilizing glycolysis even in the presence of oxygen to generate ATP.
Silvia D’amico, Sara Giovannini, Gerry Melino, Angelo Peschiaroli, Francesca Bernassola   +4 more
doaj   +2 more sources

Lactylation of HMGB1 at K177 Drives Nuclear Export of TIAR to Promote Hypoxia‐Induced Stress Granule Formation

Advanced Science
HMGB1, one of the most abundant nuclear non‐histone proteins, also performs extracellular functions, and its nuclear export mechanisms have been extensively studied.
Chengyu Li, Zhaojun Liu, Linjie Zhu, Gang Wu, Chen Fu, Hongmin Li, Tong He, Ming Shen, Honglin Liu   +8 more
doaj   +2 more sources

Research Progress of Lactylation in Age-related Diseases [PDF]

Zhongguo quanke yixue
Lactylation (Kla) is a novel mechanism of protein post-translational modification, which is formed by covalent coupling of lactate produced by glycolysis with lysine residues, mainly including histone lactylation and non-histone lactylation.
WU Miaomiao, LI Pengfei, XU Linhui, KANG Lihua, JI Min, WANG Yong, GUAN Huaijin
doaj   +2 more sources

Lactylation: From Molecular Insights to Disease Relevance

Biomolecules
Lactylation, referring to the covalent coupling of the lactyl group with lysine residues, is a recently defined post-translational modification. It has been demonstrated that lactylation can alter protein transcription, thereby affecting the transmission
Yao Xu, Lu Zhang, Dong Shang, Hong Xiang
doaj   +2 more sources

Lactylation as a metabolic-epigenetic nexus in epilepsy: Mechanisms and therapeutic implications

Neurobiology of Disease
Lactylation is a novel post-translational modification (PTM) mediated by lactate, which dynamically regulates protein functions and gene expression by covalently attaching lactate groups to lysine residues. Recent studies have shown that abnormal lactate
Ting Chen, Sha Wen, Ling Gong, Xianfeng Hou, Lian Dong, Ying Bai, Zucai Xu   +6 more
doaj   +2 more sources