Results 11 to 20 of about 12,544 (218)

kLa MEASUREMENT IN BIOREACTORS

Chemical Engineering Transactions, 2010
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F. Scargiali, A. Busciglio, F. Grisafi, A. Brucato   +3 more
doaj   +2 more sources

Co-Delivery of 5-Fluorouracil and Paclitaxel in Mitochondria-Targeted KLA-Modified Liposomes to Improve Triple-Negative Breast Cancer Treatment

Pharmaceuticals, 2022
In this research, KLA-modified liposomes co-loaded with 5-fluorouracil and paclitaxel (KLA-5-FU/PTX Lps) were developed, and their antitumor activity against triple-negative breast cancer (TNBC) was evaluated.
Tianyu Chen, Hui Chen, Yichun Jiang, Qi Yan, Shuling Zheng, Min Wu   +5 more
doaj   +2 more sources

HADHA ^K406 Lactylation Regulates Metabolic Reprogramming and Suppresses Immune Responses in Gastric Cancer. [PDF]

Adv Sci (Weinh)
HADHA K406 lactylation fuels fatty acid β‐oxidation and HMGCR‐dependent cholesterol biosynthesis, fostering immunosuppressive MDSCs and exhausted CD8+ T cells in gastric cancer. Loss of this modification blocks cholesterol production, remodels the tumor microenvironment, and tumor growth is suppressed via combined inhibition of HMGCR and LDHA ...
Feng M, Jiao Q, Zhu J, Ren Y, Teng X, Su X, Li Z, Cai Y, Liu X, Wang Y, Zhang G.   +10 more
europepmc   +2 more sources

ACAT1-Mediated SP1-K694 Lactylation Promotes M1 Macrophage Polarization via TREM1 Transcription in COPD. [PDF]

Adv Sci (Weinh)
Upon cigarette smoke exposure(CSE), LDHA expression is increased in lung macrophages, promoting the conversion of pyruvate to lactate and elevating the lactylation level of SP1 at the K694 site. This, in turn, enhances SP1 enrichment at the TREM1 promoter, increases TREM1 expression, promoted M1 macrophage polarization, and triggers the secretion of ...
Lin L, Zhang P, Song Q, Li T, Zeng Y, Chen P.   +5 more
europepmc   +2 more sources

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation. [PDF]

Adv Sci (Weinh)
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Tian Y, Ma S, Yang B, Gao F, Guo H, Liu H, Wu X, Cui W, Dong J, Lin Q, Ge Y, Ma J, Zhao J, Zhang Y, Xue D, Tian J, Zhang Z, Wang K, Xu M, Feng D, Zhou J, Qu Y.   +21 more
europepmc   +2 more sources

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated-Acute Kidney Injury. [PDF]

Adv Sci (Weinh)
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Liang H, Jiang J, Yin H, Liu C, Huang H, Luo Y, Zhu M, Wang Q.   +7 more
europepmc   +2 more sources

Modeling the time-dependence of the photoreflectance spectroscopy on ultra-shallow As+ ion implanted silicon

Results in Optics, 2022
Using a high throughput Photoreflectance (PR) spectroscopy setup, a significant temporal behavior of the PR spectroscopy from a wide range of silicon (Si) wafers is observed, induced by optical heating effect.
Houssam Chouaib
doaj   +1 more source

Identification of SIRT3 as an eraser of H4K16la

iScience, 2023
Summary: Lysine lactylation (Kla) is a novel histone post-translational modification discovered in late 2019. Later, HDAC1-3, were identified as the robust Kla erasers.
Zhuming Fan, Zhiyang Liu, Nan Zhang, Wenyu Wei, Ke Cheng, Hongyan Sun, Quan Hao   +6 more
doaj   +1 more source

Terrorism of the Kosovo Liberation Army [PDF]

Baština
This scientific paper analyzes aspects of the actions of the Kosovo Liberation Army (KLA) in the context of armed conflicts in the Balkans, with the aim of determining the extent to which the activities of this organization can be qualified as terrorism.
Bursać Boris Lj
doaj   +1 more source

Gambaran Pemenuhan Hak Anak serta Faktor-Faktor yang Mendukung pada Klaster Kesehatan Dasar dan Kesejahteraan dalam Implementasi Kebijakan Kota Layak Anak Kota Bukittinggi tahun 2019

Jurnal Kesehatan Andalas, 2020
Abstrak Salah satu upaya pemerintah untuk mendukung pemenuhan dan perlindungan hak anak dengan mengembangkan Kabupaten/ Kota Layak Anak (KLA). Kota Bukittinggi sudah menginisiasi kebijakan KLA sejak tahun 2015, tetapi masih ada permasalahan anak yang ...
Darmayanti Darmayanti, Nur Indrawaty Lipoeto   +1 more
doaj   +1 more source