Results 1 to 10 of about 12,544 (218)

Identification of Lysine Lactylation (Kla)-Related lncRNA Signatures Using XGBoost to Predict Prognosis and Immune Microenvironment in Breast Cancer Patients

Scientific Reports
Breast cancer (BC) stands as a predominant global malignancy, significantly contributing to female mortality. Recently uncovered, histone lysine lactylation (kla) has assumed a crucial role in cancer progression.
Jianlin Shen
exaly   +3 more sources

Lysine lactylation in glioma: from metabolic stress to epigenetic remodeling and therapeutic resistance [PDF]

Frontiers in Cell and Developmental Biology
Glioma is characterized by profound metabolic reprogramming and sustained lactate accumulation; however, the mechanisms by which lactate-rich metabolic stress is translated into stable malignant phenotypes remain incompletely understood.
Xiaosong Hu, Xiaosong Hu, Li Yang, Li Yang, Yanghao Hu, Yanghao Hu, Hongjuan Cui, Hongjuan Cui   +7 more
doaj   +2 more sources

Lysine lactylation‐mediated post‐translational modification: Molecular mechanisms and therapeutic target exploration in tumour drug resistance [PDF]

Clinical and Translational Medicine
Background Tumour drug resistance remains a major hurdle in cancer treatment, with post‐translational modifications (PTMs) playing a pivotal role in this process.
Juan Li, Yan Shang, Haojie Wu, Shenglong Yang, Maiqun Zuo, Hailong Zhao   +5 more
doaj   +2 more sources

The role of lactylation in age-related diseases: a molecular perspective [PDF]

PeerJ
Lactylation (Kla) is a novel post-translation protein modification regulation mechanism realized by the covalent coupling of lactate generated by glycolysis and lysine residues. Lactylation primarily includes histone Kla and non-histone Kla.
Pengfei Li, Miaomiao Wu, Linhui Xu, Min Ji, Huaijin Guan   +4 more
doaj   +3 more sources

Global Profiling of Protein Lysine Lactylation in Mouse Cardiac Hypertrophy: A Lactylome Analysis [PDF]

Journal of Cardiovascular Development and Disease
Background: Cardiac hypertrophy, a major feature of heart failure, is closely linked to metabolic remodeling and energy deficiency. Lysine lactylation (Kla), a recently discovered post-translational modification (PTM), has been implicated in various ...
Wengen Zhu, Siyu Guo, Yunyao Yang, Yugang Dong, Chen Liu, Cong Chen   +5 more
doaj   +2 more sources

Nano-Engineered Delivery of the Pro-Apoptotic KLA Peptide: Strategies, Synergies, and Future Directions

Biomolecules
Antimicrobial peptides have been increasingly recognized as potential anticancer agents, with the KLA peptide (KLAKLAK2) being one of the most well-known and successful examples.
Eun-Taex Oh, Ha Gyeong Kim, Yunmi Cho
exaly   +3 more sources

Lysine lactylation (Kla) might be a novel therapeutic target for breast cancer

BMC Medical Genomics, 2023
Background Histone lysine lactylation (Kla) is a newly identified histone modification, which plays a crucial role in cancer progression. Hence, we determined the prognostic value of Kla in breast cancer (BC).
Jian Deng, Xinyi Liao
doaj   +1 more source

High-Intensity Interval Training Induces Protein Lactylation in Different Tissues of Mice with Specificity and Time Dependence

Metabolites, 2023
Protein lysine lactylation (Kla) is a novel protein acylation reported in recent years, which plays an important role in the development of several diseases with pathologically elevated lactate levels, such as tumors.
Wenhua Huang, Jie Su, Xuefei Chen, Yanjun Li, Zheng Xing, Lanlan Guo, Shitian Li, Jing Zhang   +7 more
doaj   +1 more source

Identification of lysine-lactylated substrates in gastric cancer cells

iScience, 2022
Summary: Cancer cells tend to utilize aerobic glycolysis to generate energy and metabolites; the end product of aerobic glycolysis is lactate, which promotes lysine lactylation (Kla). Kla is a newly discovered histone post-translational modification (PTM)
Dawei Yang, Jie Yin, Liuqun Shan, Xingling Yi, Wei Zhang, Yongbin Ding   +5 more
doaj   +1 more source

FSL-Kla: A few-shot learning-based multi-feature hybrid system for lactylation site prediction

Computational and Structural Biotechnology Journal, 2021
As a novel lactate-derived post-translational modification (PTM), lysine lactylation (Kla) is involved in diverse biological processes, and participates in human tumorigenesis.
Peiran Jiang, Wanshan Ning, Yunshu Shi, Chuan Liu, Saijun Mo, Haoran Zhou, Kangdong Liu, Yaping Guo   +7 more
doaj   +1 more source