Results 41 to 50 of about 12,544 (218)

KLA

, 2014
This paper proposes a new algorithmic paradigm - k-level asynchronous (KLA) - that bridges level-synchronous and asynchronous paradigms for processing graphs.
Amato, Nancy M., Rauchwerger, Lawrence, Adam Fidel, Fidel, Adam, Lawrence Rauchwerger, Nancy M. Amato, Harshvardhan   +6 more
core   +1 more source

DeepKla: An attention mechanism‐based deep neural network for protein lysine lactylation site prediction

iMeta, 2022
As a newly discovered protein posttranslational modification, lysine lactylation (Kla) plays a pivotal role in various cellular processes. High throughput mass spectrometry is the primary approach for the detection of Kla sites.
Hao Lv, Fu‐Ying Dao, Hao Lin
doaj   +1 more source

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, EarlyView.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source

Biomechanical Properties Required for the Reduction of Knee Adduction Moment Using Gait Modification in Individuals With Obesity

Archives of Rehabilitation Research and Clinical Translation
Objective: To investigate the effects of gait modification on the knee lever arm (KLA) in individuals with obesity. Design: This study was designed as a retrospective, cross-sectional, observational study to investigate the impact of gait modifications ...
Munkhdelger Dorjravdan, BSc, Kimihiko Mori, PT, PhD, Tomohiro Ushikubo, PhD, Takanari Kubo, PT, PhD, Yasuaki Arima, PT, PhD, Naoto Mano, PT, PhD, Masanori Wakida, PT, PhD, Yuta Chujo, PT, PhD, Meguru Taguchi, MD, Yutaka Kimura, MD, PhD, Kimitaka Hase, MD, PhD   +10 more
doaj   +1 more source

p300‐Mediated H3K18 Lactylation Drives Radiation‐Induced Pulmonary Fibrosis via VIRMA‐Dependent m6A Modification of GATA3

Advanced Science, EarlyView.
Radiation triggers glycolytic reprogramming in alveolar epithelial type II cells, causing pathological lactate accumulation. This metabolic stress drives p300‐mediated H3K18 lactylation at the VIRMA promoter, activating transcription. Elevated VIRMA enriches m6A on GATA3 mRNA, which YTHDF1 stabilizes, ultimately driving epithelial–mesenchymal ...
Junxuan Yi, Mingwei Wang, Duo Yu, Mingqi Zhao, Xinyan Wang, Shiqi Li, Xiaowen Han, Wei Wei, Shunzi Jin   +8 more
wiley   +1 more source

An in-tether chiral center modulates the proapoptotic activity of the KLA peptide

, 2017
The helical peptide KLA (KLAKLAKKLAKLAK) is a well-known inducer of cellular apoptosis, acting to disrupt the mitochondrial membrane. However, its weak cellular uptake impedes development of any further applications.
Hailing Chen, Longjian Chen, Yuan Tian, YuJie Wu, Jingxu Li, Feng Yin, Zigang Li, Kuan Hu   +7 more
core   +1 more source

ANALISIS PELAKSANAAN PROGRAM KABUPATEN LAYAK ANAK (KLA) DI DESA PASIR KERANJI KECAMATAN PASIR PENYU KABUPATEN INDRAGIRI HULU [PDF]

, 2017
Penelitian ini bertujuan untuk mengetahui sejauh mana Pelaksanaan Program Kabupaten Layak Anak (KLA) di Desa Pasir Keranji Kecamatan Pasir Penyu Kabupaten Indragiri Hulu. Informan dalam penelitiuan ini adalah orang yang terlibat dalam KLA ini seperti
MOULID DIANA
core   +1 more source

Worth the Effort to Achieve the City of Children in Surakarta Makassar

Jurnal Bina Praja, 2015
This study is about child-friendly city (KLA). This research is motivated by the lack of attention of the local government in protecting children and the issuance of Law No.
Moh. Ilham A. Hamudy
doaj   +1 more source

Systematic Analysis of Lysine Lactylation in the Plant Fungal Pathogen Botrytis cinerea

Frontiers in Microbiology, 2020
Lysine lactylation (Kla) is a newly discovered histone post-translational modification (PTM), playing important roles in regulating transcription in macrophages. However, the extent of this PTM in non-histone proteins remains unknown. Here, we report the
Mingming Gao, Ning Zhang, Wenxing Liang
doaj   +1 more source

Lactylation‐Driven PROS1‐TYRO3‐CARF Signaling Promotes Therapy‐Induced Senescence Escape and Radioresistance in Meningioma

Advanced Science, EarlyView.
A glycolysis‐driven epigenetic switch promotes therapy resistance in meningioma. Increased lactate production enhances histone H3K27 lactylation, which activates PROS1 secretion. Secreted PROS1 engages TYRO3 signaling to degrade the senescence regulator CARF, allowing cancer cells to escape growth arrest.
Zhuohang Wang, Qixiang Zhang, Keman Liao, Xiaoyu Liu, Hongchi Zhang, Yunsheng Chen, Yuxiao Ma, Yikui Liu, Aoqian Xu, Yuhao Sun, Jiayi Chen, Liuguan Bian, Baofeng Wang   +12 more
wiley   +1 more source