Results 91 to 100 of about 12,544 (218)

Challenges in meeting the mass transfer demands of high‐density perfusion cultures in single‐use bioreactors

Biotechnology Progress, EarlyView.
Abstract Increasing protein therapeutics production by adopting intensified perfusion cultures places high demand on the mass transfer capabilities of single‐use bioreactors (SUB). Here, we compare these capabilities for four SUB designs against worst‐case O2 transfer requirements for supporting Chinese hamster ovary (CHO) perfusion cultures. Impact of
Anita B. Dabek, Anthony M. Beaney, Mauran Mahendra, Mikayla Olin, Anastasia Eftychidou, Joanna D. Kolacz, Natalia Papalamprou, Marissa R. Dickson, Patrick Romann, Colin Jaques   +9 more
wiley   +1 more source

Lactylation in concert with other post-translational modifications: Regulatory networks and disease implications

Cell Investigation
Lactate and lysine lactylation (Kla) have evolved from being viewed as metabolic end products to key molecular mediators linking cellular metabolism to chromatin dynamics and signaling outputs.
Ziqi Fu, Ruohan Shi, Li Jiang, Weiwei Zhang, Yuan Liu, Wenquan Chen, Fuzhi Zhu, Rui Chen, Gongsheng Jin, Yuzhong Chen, Jia Liu   +10 more
doaj   +1 more source

İki kardeşte gözlenen konjenital lober amfizem

Sakarya Tıp Dergisi, 2012
Konjenital lober amfizem (KLA) genellikle bir lobda hiperinflasyonla karakterizedir. Sol üst lob (%50) ve sağ orta lob (%30) en sık etkilenmekte olup bunu sağ üst lob izlemektedir. Literatürde aile öyküsü ile KLA arasında bir ilişkiden bahsedilmemektedir.
Atila Türkyılmaz, Atilla Eroğlu, Aysel Kurt, Niyazi Diri, Yener Aydın   +4 more
doaj   +1 more source

Towards Halogen Bonding MOFs: Networking With a Polyiodinated and Perfluorinated Terphenyl Ligand and Divalent Zinc

Chemistry – A European Journal, EarlyView.
One ligand, three new architectures with different intermolecular interactions: a polyhalogenated terphenyl linker with carboxyl groups coordinates Zn2+ to form (i) a metal‐containing hydrogen‐bonded organic framework; (ii) a metal‐organic framework or (iii) one‐dimensional metal‐organic chains with intermolecular halogen bonding and hydrogen bonding ...
Elad Gaver, Christoph J. Vonnemann, Julian Stoesser, Jennifer A. E. Rühle, Mark A. Iron, Linda J. W. Shimon, Michal Lahav, Stefan M. Huber, Milko E. van der Boom   +8 more
wiley   +1 more source

Global profiling of protein lactylation in pancreatic ductal adenocarcinoma

Scientific Reports
Cancer cells dramatically increase L-lactate production, fueling lysine lactylation (Kla) – a posttranslational modification that rewires protein function and links metabolic flux to gene and pathway regulation. Although emerging studies implicate Kla in
Daniela Toledo, Samuel Abidemi Oluwole, Solomon Owiredu, Grace Carr, Christian Agatemor   +4 more
doaj   +1 more source

A lumped modelling framework for the epoxidation of vegetable oils and fatty acid methyl esters

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract Epoxidized vegetable oils and fatty acid methyl esters are promising bio‐based alternatives to phthalates for plasticizer applications. Their synthesis typically involves the reaction of unsaturated double bonds with peracetic acid in a biphasic liquid–liquid system, where the simultaneous occurrence of reaction and phase partitioning makes ...
Irene Presti, Carlo Pirola, Francesco Megna, Federico Galli   +3 more
wiley   +1 more source

Effect of ultrasonic irradiations on gas-liquid mass transfer coefficient (kLa); Experiments and modelling

, 2016
Sonochemical reactors have proven to be very useful for intensification of various reaction systems. However, there is a lack of understanding in mass transfer mechanism under ultrasonication due to dependency of mass transfer on various parameters.
Parthasarathy, R., Ghotli, R.A., Davoody, M., Abdul Raman, Abdul Aziz, Asgharzadehahmadi, S.   +4 more
core   +1 more source

HBO1 catalyzes lysine lactylation and mediates histone H3K9la to regulate gene transcription

Nature Communications
Lysine lactylation (Kla) links metabolism and gene regulation and plays a key role in multiple biological processes. However, the regulatory mechanism and functional consequence of Kla remain to be explored.
Ziping Niu, Chen Chen, Siyu Wang, Congcong Lu, Zhiyue Wu, Aiyuan Wang, Jing Mo, Jianji Zhang, Yanpu Han, Ye Yuan, Yingao Zhang, Yong Zang, Chaoran He, Xue Bai, Shanshan Tian, Guijin Zhai, Xudong Wu, Kai Zhang   +17 more
doaj   +1 more source

High Cell Density Cultivation of HEK293 Cells Using a 2L Membrane-Stirred Bioreactor. [PDF]

Biotechnol Bioeng
ABSTRACT The use of perfusion systems for the continuous cultivation of animal cells at high cell density (HCD) for the production of recombinant proteins, viruses, and viral vectors has many advantages. Besides an enhancement of volumetric productivity and high cell viability, the product quality can be improved through a steady‐state environment ...
Jacobtorweihe L, van Heuvel Y, Scheiermann K, Bongartz P, Genzel Y, Reichl U.   +5 more
europepmc   +2 more sources

Optimal subsampling for regression with mixed‐type predictors

Canadian Journal of Statistics, EarlyView.
Abstract Subsampling has emerged as an appealing strategy to mitigate the computational and storage challenges imposed by large datasets. Recent subsampling techniques have shown notable computational gains for data dominated by numerical predictors. However, real‐world datasets frequently contain both numerical and categorical predictors.
Jiaqing Zhu, Lin Wang, Fasheng Sun
wiley   +1 more source