Results 111 to 120 of about 12,544 (218)

Towards a single empirical correlation to predict kLa across scales and processes

open access: yes, 2014
Mathematical models are increasingly used in fermentation. Nevertheless, one of the major limitations of these models is that the parameters they include are process specific, e.g. the volumetric mass transfer coefficient (kLa).
Stocks, Stuart M.   +3 more
core  

Lysine lactylation in diseases: beyond histone lactylation

open access: yesCell Death and Disease
Lactylation, a recently identified post-translational modification, was initially characterized as lysine residue modification in histone subunits that regulates gene transcription via epigenetic mechanisms.
Yiming Liu   +6 more
doaj   +1 more source

Stripping‐based approach for the recovery of volatile fatty acids from anaerobic digestion digestate: preliminary experimental investigations and modelling

open access: yesJournal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Volatile fatty acids (VFAs) are widely used across industries: as intermediates in chemical production (e.g., solvents and polymers), in pharmaceuticals and cosmetics, and as preservatives and health‐promoting additives in food and animal feed. Emerging applications also include bioplastics, bioenergy, and biotechnology.
Simeone Chianese   +6 more
wiley   +1 more source

Apoptosis induced by kla with or without HPRP-A1.

open access: yes, 2019
(A) MCF-7 and A549 cells were treated with various concentrations of kla with or without 4 μM HPRP-A1 for 12 h, and then the rates of early and late apoptosis of (B) MCF-7 and (C) A549 cells were measured using a FITC-Annexin V/PI kit and flow cytometry (
Cuihua Hu (4794147)   +3 more
core   +1 more source

Slice‐Wise Quality Assessment of High b Value Breast DWI via Deep Learning‐Based Artifact Detection

open access: yesJournal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Diffusion‐weighted imaging (DWI) can support lesion detection and characterization in breast MRI. Therefore, DWI is increasingly being incorporated into breast MRI protocols to address some of the shortcomings of routine clinical breast MRI.
Ameya Markale   +13 more
wiley   +1 more source

Rhaponticin Blocks Glycolysis‐Mediated Histone Lactylation to Suppress Tongue Squamous Cell Carcinoma via HIF‐1α Activity Inhibition

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Tongue squamous cell carcinoma (TSCC) often develops therapeutic resistance. Metabolic reprogramming, particularly the glycolysis/lactate/histone lactylation axis, is a critical driver of tumor progression and therapy resistance. This study investigated the anti‐tumor mechanism of Rhaponticin (Rha), focusing on the metabolic/epigenetic axis ...
Yuan Wu   +7 more
wiley   +1 more source

Enhanced anticancer efficacy of paclitaxel through multistage tumor-targeting liposomes modified with RGD and KLA peptides

open access: yes, 2017
Jiawei Sun,1 Lei Jiang,2 Yi Lin,3 Ethan Michael Gerhard,4 Xuehua Jiang,1 Li Li,3 Jian Yang,4 Zhongwei Gu3 1West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, 2Department of Pharmaceutics, China Pharmaceutical University, Nanjing ...
Yang J   +7 more
core  

Transmission‐Mode Silicon‐Rich Nitride Mie‐Void Metasurfaces in the Visible

open access: yesLaser &Photonics Reviews, EarlyView.
Transmission‐mode Mie‐void metasurfaces are demonstrated in silicon‐rich nitride, where localized void resonances hybridize with slab‐guided and Fabry–Pérot‐like modes in a finite film, producing a quantified avoided crossing between coupled modes. Controlled void depth tunes the visible transmission spectrum, enabling structural color and spatial ...
Oren Goldberg, Noa Mazurski, Uriel Levy
wiley   +1 more source

Extreme Silk Toughness in Caerostris Spiders Is Limited to Adult Females

open access: yesIntegrative Zoology, EarlyView.
We ask whether species with exceptionally tough silk, like Caerostris bark spiders, show different developmental patterns in silk toughness between ontogenetic stages and sexes. We found that only large females produce exceptionally tough silk with higher initial stiffness, while juvenile females as well as adult and juvenile males produce inferior ...
Matjaž Gregorič   +4 more
wiley   +1 more source

Comprehensive analysis of lysine lactylation and its potential biological significance in clear cell renal cell carcinoma

open access: yesEuropean Journal of Medical Research
Background Clear cell renal cell carcinoma (ccRCC) is a common histological subtype of malignant renal neoplasm. Protein lysine lactylation (Kla) plays a crucial role in tumor metabolic reprogramming.
Bangbei Wan   +4 more
doaj   +1 more source

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