This comprehensive review summarizes gastric cancer epidemiology, multifactorial risk factors (like infectious, dietary, genetic), pathogenesis such as precancerous evolution, molecular alterations, and a focus on the bidirectional interactions between gastric cancer cells and macrophages in the tumor microenvironment.
Yixuan Xin +6 more
wiley +1 more source
Lactylation in cancer: a new frontier in metabolic-epigenetic regulation and clinical practice. [PDF]
Zhang Y +6 more
europepmc +1 more source
Protein Lactylation in Cancer: From Mechanisms to Therapy
Increased glycolysis and lactate accumulation promote histone and nonhistone protein lactylation, linking tumor metabolic reprogramming to treatment adaptation. Lactylation enhances DNA repair, suppresses antitumor immunity, strengthens antioxidant defenses, and facilitates cell‐cycle checkpoint escape, collectively promoting resistance to chemotherapy,
Wentian Huang +8 more
wiley +1 more source
Cysteine Thioaldehydes: Photolytic Generation, Reactivity, and Biological Implications
Photolysis of cysteine phenacylsulfides bearing non‐conjugating electron‐withdrawing substituents leads to high conversions into cysteine thioaldehydes through a Norrish type‐II pathway. This methodology enabled the study of the aqueous reactivity of these important biosynthetic intermediates, which, depending on peptide sequence, pH and buffer ...
Ardra Karthika +9 more
wiley +2 more sources
XGBoost-Assisted Effluent Ammonium Buffer-First Aeration Scheduling for Wastewater Treatment Under Influent Disturbances: A BSM2 Study. [PDF]
Ren H +5 more
europepmc +1 more source
This review examines how histone modifications integrate aging, metabolic dysfunction and neuroinflammation to shape persistent, cell‐type‐specific chromatin states in Alzheimer's disease. By distinguishing causal regulation from association through perturbation, persistence and reversibility, it highlights metabolic–epigenetic feedback loops and ...
Junyi Liang +7 more
wiley +1 more source
Activation-induced cytidine deaminase sustains glycolytic flux through MYST1 acetyltransferase-dependent lactylation in hepatocellular carcinoma. [PDF]
Jiao J, Zhang K, Li B, Yang A, Lv Z.
europepmc +1 more source
ABSTRACT Only 5% of the Haitian population is fully bilingual in French and Kreyòl. On the contrary, 95% of the population is monolingual in the native language, Kreyòl. The purpose of this research is to examine the attitudes of Haitian high school students toward Kreyòl and French, particularly as official languages, and investigate the effects of ...
Gerdine Michel Ulysse
wiley +1 more source
Antibiotic tolerance coupled with limited benefit from drainage: Clinical challenges in <i>Klebsiella pneumoniae</i> liver abscess. [PDF]
Gong Z +5 more
europepmc +1 more source
Daily Heat Stress Induces Donor‐Side Limitation of PSI Via Downregulation of the Cyt b6f Complex
ABSTRACT The rapidly warming climate is driving increasingly frequent and intense heat waves worldwide, posing major challenges to plant metabolism and growth. Despite the central role of photosynthesis in plant growth, the effects of prolonged heat stress on the primary reactions of photosynthesis remain poorly understood.
Laura Laihonen +5 more
wiley +1 more source

