Results 61 to 70 of about 5,771 (170)

SATB2 Mediates H3K9 Delactylation by Recruiting HDAC3 to Repress LCN2 and Inhibit Lung Tumor Growth and Metastasis

Advanced Science, EarlyView.
This study highlights the capacity for tumor suppressor SATB2 to recruit HDAC3 and catalyze histone H3K9 delactylation, thereby repress transcription of the oncogene LCN2. This novel epigenetic‐metabolic axis inhibits the growth and metastasis of non‐small cell lung cancer, delineating a new mechanistic pathway with potential therapeutic relevance ...
Ting Wen, Lihua Yang, Shuang Cai, Yunxia Liu, Jianan Fan, Peng Wu, Beibei Gao, Xiaoge Xie, Hong Sun, Sida Qin, Qiao Yi Chen   +10 more
wiley   +1 more source

Identification of lysine lactylation (kla)-related lncRNA signatures using XGBoost to predict prognosis and immune microenvironment in breast cancer patients

Scientific Reports
Breast cancer (BC) stands as a predominant global malignancy, significantly contributing to female mortality. Recently uncovered, histone lysine lactylation (kla) has assumed a crucial role in cancer progression.
Feng Lin, Hang Li, Huan Liu, Jianlin Shen, Lemin Zheng, Shunyi Huang, Yu Chen   +6 more
doaj   +1 more source

Lactylation Reprogramming in the Bone Infection Microenvironment Identifies PGK1 K361 as a Potential Therapeutic Target for Osteogenic Dysfunction

Advanced Science, EarlyView.
Staphylococcus aureus (S. aureus) infection creates a high‐lactate microenvironment, promoting p300‐mediated lactylation of PGK1 at lysine 361 (K361). Lactylated PGK1 translocates to the mitochondrial outer membrane and interacts with VDAC3. This interaction triggers FtMt downregulation, iron accumulation, and excessive PINK1/Parkin‐mediated mitophagy,
Han‐jun Qin, Si‐ying He, Ting‐hui Xiao, Da‐mao Dai, Xin‐jia Hu, Nan Jiang   +5 more
wiley   +1 more source

HYDRODYNAMICS OF A CONCENTRIC TUBES AIRLIFT REACTOR

Diyala Journal of Engineering Sciences, 2010
In airlift reactors transport phenomena are achieved by pneumatic agitation and circulation occurs in a defined cyclic pattern through a loop. In the present work, the effect of geometrical relations on gas holdup and liquid velocity, and consequently ...
Aseel Abd Aljabbar
doaj  

Perilaku Masyarakat Desa Terpencil Menonton Tayangan Televisi

Aplikasia, 2017
Pada tahun 2011, Kementerian Negara Pemberdayaan Perempuandan Perlindungan Anak (Kemenneg PPPA) menginisiasi Kabupaten/Kota Layak Anak (KLA) sebagai suatu sistem pembangunan berbasis hak anak di level kabupaten atau kota melalui pengintegrasian komitmen ...
Abdul Rozak
doaj   +1 more source

Fabrication of High‐Density Multimodal Neural Probes Based on Heterogeneously Integrated CMOS

Advanced Science, EarlyView.
A chiplet‐based methodology democratizes active neural probe development on standard bulk CMOS services. This yields the first probe combining high‐density electrophysiology (416 electrodes) with calcium imaging (832 photodiodes) and complete on‐chip signal processing across 13 shanks.
Ju Hee Mun, Miji Kim, Wooyeon Shin, Yongjun Park, Kanghwan Kim, Il‐Joo Cho, Jae Won Shim, Min Soo Kim, Sunwoo Lee, Jeongjin Kim, Changhyuk Lee   +10 more
wiley   +1 more source

Quo Vadis Partisipasi Masyarakat Dalam Kebijakan Kabupaten Layak Anak (KLA) Sleman

Aplikasia, 2017
Pada tahun 2011, Kementerian Negara Pemberdayaan Perempuandan Perlindungan Anak (Kemenneg PPPA) menginisiasi Kabupaten/Kota Layak Anak (KLA) sebagai suatu sistem pembangunan berbasis hak anak di level kabupaten atau kota melalui pengintegrasian komitmen ...
Muhammad Izzul Haq
doaj   +1 more source

Redox‐Responsive Polymeric Nanocapsules for Enhanced Tumor‐Targeted Delivery of Antimicrobial Peptides

Advanced Science, EarlyView.
This study presents a modular redox‐responsive nanocapsule platform that enables enhanced tumor‐targeted delivery of antimicrobial peptides. Using melittin as an example, the system achieves controlled activation within the tumor microenvironment, improving intratumoral accumulation while minimizing systemic toxicity.
Lin Tang, Yajian Li, Xiaoyin Lv, Jianmei Guo, Yijia Zhang, Yuqi Lin, Kaili Nie, Jian Zeng, Ming Zhang, Qiong Dai   +9 more
wiley   +1 more source

Solution Processed Polymer Source‐Gated Transistors for Zero‐Power Photosensing

Advanced Electronic Materials, EarlyView.
This study demonstrates the first solution‐processed bulk heterojunction organic source‐gated transistors (OSGTs) and photo‐OSGTs fabricated using DPP‐DTT: PCBM. Copper‐electrode OSGTs show deep off‐state at zero gate‐source voltage, channel length‐independent on‐state current, and low voltage saturation (γ = 0.22).
Eva Bestelink, Ahmed Wafic, Mattia Scagliotti, Dimitar Kutsarov, Imalka Jayawardena, Matteo Rapisarda, Radu A. Sporea   +6 more
wiley   +1 more source

An Increasing Prominent Disease of Klebsiella pneumoniae Liver Abscess: Etiology, Diagnosis, and Treatment

Gastroenterology Research and Practice, 2013
Background. During the past two decades, Klebsiella pneumoniae (K. pneumoniae) had surpassed Escherichia coli (E. coli) as the predominant isolate from patients with pyogenic liver abscess (PLA) in Asian countries, the United States, and Europe, and it ...
Yun Liu, Ji-yao Wang, Wei Jiang
doaj   +1 more source