Krüppel‐Like Factor 4, a Hub Gate for Cell Crosstalk in Tumor Microenvironment [PDF]
Cancer MedicineObjective Krüppel‐like factor 4 (KLF4) is a zinc finger transcription factor that plays context‐dependent roles in cancer. It functions as either a tumor suppressor or an oncogene depending on tumor type and cellular context.
Min Tang +5 more
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KLF4 transactivates TRIM29 expression and modulates keratin network
Biochemistry and Biophysics Reports, 2021 The Krüppel-like factor 4 (KLF4) is well known to be a conserved zinc-containing transcription factor that participates in diverse biological processes such as cell proliferation and differentiation. In this study, we found KLF4 can bind specific site in
Runqing Huang, Yang Fu, Yanhong Deng
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Mechanism of miR-206 in Regulating KLF4 and Affecting Th17 Cell Differentiation in Neutrophil Asthma Inflammation [PDF]
Journal of Asthma and AllergyLiting Feng, Yingna Li, Lulu Zhang, Yanqing Xing, Rujie Huo, Erjing Cheng, Xinrui Tian Department of Gerontology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of ChinaCorrespondence: Xinrui Tian, Department of ...
Feng L +6 more
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Cancer Medicine, 2020 Krüppel‐like factor 4 (KLF4) has a tumor suppressor role in the progression of gastric cancer (GC), and inhibition or loss of KLF4 expression was identified in GC.
Rongrong Zhao +7 more
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Circular RNA hsa_circ_0099188 regulates inducible nitric oxide synthase and chemokine transcription in macrophages by targeting the hsa-miR-381-3p/PPP3CA and hsa-miR-381-3p/KLF4 pathways in response to 4,4'-methylene diphenyl diisocyanate-glutathione conjugate exposure. [PDF]
Toxicol SciLin CC, Law BF, Hettick JM.
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Evaluation of miR-107, DAPK1, and KLF4 Expression in Colorectal Tumors and Effect of Oxaliplatin and 5-FU on their Levels in Colorectal Cancer Cell Lines [PDF]
Middle East Journal of Cancer, 2021 Background: In recent years, the role of micro-RNAs in the cancer pathophysiology has attracted a great deal of scientific attention. MiRNAs regulate a variety of cellular functions, such as apoptosis, differentiation and migration by targeting oncogenic
Sahar Safaei +8 more
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KLF4 transcription factor in tumorigenesis
Cell Death Discovery, 2023 AbstractKrüppel-like transcriptional factor is important in maintaining cellular functions. Deletion of Krüppel-like transcriptional factor usually causes abnormal embryonic development and even embryonic death. KLF4 is a prominent member of this family, and embryonic deletion of KLF4 leads to alterations in skin permeability and postnatal death.
Zhihong He, Jie He, Keping Xie
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Zhongliu Fangzhi Yanjiu, 2021 Objective To investigate the role of LncRNAs-MEG3 in the carcinogenesis and progression of nasopharyngeal carcinoma (NPC) and the possible molecular mechanism. Methods qRT-PCR was used to detect the content of MEG3 and miR-543 in NPC cells.
NING Jiayu +4 more
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Endothelial KLF4: Crippling Vascular Injury? [PDF]
Journal of the American Heart Association, 2014 The health of the vascular endothelium is critical for normal vascular physiologic function, and dysfunction of the endothelium can lead to development of vascular disease, such as atherosclerosis and thrombosis.
Tugal, Derin +2 more
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Interplay Between KLF4, STAT, IRF, and NF-κB in VSMC and Macrophage Plasticity During Vascular Inflammation and Atherosclerosis. [PDF]
Int J Mol SciLopacinska N, Wesoly J, Bluyssen HAR.
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