Results 91 to 100 of about 55,031 (288)

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

Investigation and Comparison of Communication Network and Expression of KLF4 and POU5F1 Genes During Spermatogenesis [PDF]

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām
Introduction:  Spermatogenesis is the primary process of sperm production occuring in seminiferous tubules. Spermatogonial stem cells (SSCs) have the ability for self-renewal, differentiation, and the transmission of genetic information to subsequent ...
Maedeh Yazdani Dizicheh, Hossein Azizi, Dariush Gholami, Amir Khaki   +3 more
doaj  

Regenerative Medicine for the Aging Brain [PDF]

, 2014
In the central nervous system, cholinergic and dopaminergic (DA) neurons are among the cells most susceptible to the deleterious effects of age. Thus, the basal forebrain cholinergic system is known to undergo moderate neurodegenerative changes during ...
Goya, Rodolfo Gustavo, Hereñú, Claudia Beatriz, López León, Micaela, Reggiani, Paula Cecilia   +3 more
core   +2 more sources

Manipulation of KLF4 Expression Generates iPSCs Paused at Successive Stages of Reprogramming [PDF]

, 2014
The detailed mechanism of reprogramming somatic cells into induced pluripotent stem cells (iPSCs) remains largely unknown. Partially reprogrammed iPSCs are informative and useful for understanding the mechanism of reprogramming but remain technically ...
Ayakawa Daisuke, Chen Chen, Fukuda Aya, Hisatake Koji, Kato Tetsuo, Nakanishi Mahito, Nishimura Ken, Ohtaka Manami, Oinam Lalhaba, Shiomitsu Emi, 久武 幸司, 福田 綾, 西村 健   +12 more
core   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

The critical role of KLF4 in regulating the activation of A1/A2 reactive astrocytes following ischemic stroke

Journal of Neuroinflammation, 2023
Background We have previously demonstrated that the expression of kruppel-like transcription factor-4 (KLF-4) is upregulated in astrocytes following acute ischemic stroke (AIS) and found that KLF4 confers vascular protection against cerebral ischemic ...
Cong Wang, Longxuan Li
doaj   +1 more source

Gain-of-function oncogenic mutations in TP53 enhance defined factor-mediated cellular reprogramming [PDF]

, 2011
Cancer is a disorder with various genetic and epigenetic alterations. Genetic alterations such as mutations, i.e., substitutions, amplifications, and deletions of nucleotide sequences, are largely irreversible, whereas epigenetic alterations can be ...
Dyah Laksmi Dewi, Hideshi Ishii, Jeong Ho Moon, Jeong Ho Moon, Kazuyoshi Yamamoto, Masaki Mori, Shinpei Nishikawa, Yoshihiro Kano, Yoshiyuki Fujiwara, Yuichiro Doki   +9 more
core   +2 more sources

Contribution of Gli1+ Adventitial Stem Cells to Smooth Muscle Cells in Atherosclerosis and Vascular Injury

Advanced Science, EarlyView.
Gli1+ adventitial stem cells (ASCs) have been thought to generate smooth muscle cells (SMCs) in atherosclerosis. Using a dual‐recombinase lineage tracing to exclude ectopic labeling, Wang et al. found that Gli1+ ASCs do not contribute to SMCs in atherosclerotic plaques.
Haixiao Wang, Xiuzhen Huang, Jialing Mou, Enci Wang, Yan Li, Wenjuan Pu, Yao Xie, Xiaoling Guo, Lixin Wang, Maoping Chu, Bin Zhou, Chao Niu   +11 more
wiley   +1 more source

Krüppel-like Factor 4-Deficient Cells Are Sensitive to Etoposide-Induced DNA Damage

Current Issues in Molecular Biology
Krüppel-like factor 4 (KLF4) is a highly conserved zinc-finger transcription factor involved in cellular processes such as development, differentiation, and cell cycle regulation.
Maxwell H. Rubinstein, Aidan Conroy, Elisabeth L. Pezzuto, Hadeel Al Qoronz, Patrick Wertimer, Engda G. Hagos   +5 more
doaj   +1 more source

KLF4 Promotes Angiogenesis by Activating VEGF Signaling in Human Retinal Microvascular Endothelial Cells. [PDF]

PLoS ONE, 2015
The transcription factor Krüppel-like factor 4 (KLF4) has been implicated in regulating cell proliferation, migration and differentiation in a variety of human cells and is one of four factors required for the induction of pluripotent stem cell ...
Yinan Wang, Chuanhe Yang, Qingqing Gu, Michelle Sims, Weiwang Gu, Lawrence M Pfeffer, Junming Yue   +6 more
doaj   +1 more source