Results 111 to 120 of about 55,031 (288)

The Microbiota Shapes Central Nervous System Myelination in Early Life

Advanced Science, EarlyView.
Gut microbiota shapes brain development by regulating myelination and glial cell maturation in early life. Using germ‐free (GF) mice and zebrafish, this study reveals sex‐ and age‐dependent effects on myelin growth, integrity, and related gene expression.
Caoimhe M. K. Lynch, Emily G. Knox, Daniel Soong, Thomaz F. S. Bastiaanssen, Kalevi Trontti, Gabriel S. S. Tofani, Sophia Ivaschuk, Michael K. Collins, Donia Arafa, Jatin Nagpal, Iiris Hovatta, David A. Lyons, Gerard Clarke, John F. Cryan   +13 more
wiley   +1 more source

KLF4 defines the efficacy of the epidermal growth factor receptor inhibitor, erlotinib, in triple-negative breast cancer cells by repressing the EGFR gene

Breast Cancer Research, 2020
Background Triple-negative breast cancer (TNBC) is characterized by high rates of recurrence and poor overall survival. This is due, in part, to a deficiency of targeted therapies, making it essential to identify therapeutically targetable driver ...
Melyssa S. Roberts, Lindsey J. Anstine, Viviane S. Finke, Benjamin L. Bryson, Bryan M. Webb, Kristen L. Weber-Bonk, Darcie D. Seachrist, Parth R. Majmudar, Ruth A. Keri   +8 more
doaj   +1 more source

12‐HETE Is an Endogenous Modulator of BLT2 Triggering Vascular Degeneration, Dissection, and Rupture

Advanced Science, EarlyView.
In thoracic aortic dissection (TAD), elevated levels of the arachidonic acid metabolite 12‐HETE, produced by macrophage‐specific 12/15‐lipoxygenase (12/15‐LOX), bind to the BLT2 receptor on vascular cells. This activates the NOX‐1/ROS/NF‐κB signaling pathway, leading to IL‐6 release.
Yuyu Li, Jiaqi Yu, Weiyao Chen, Xue Wang, Xin Tan, Jing Cui, Yihao Wang, Xuan Xu, Rui Lin, Zhengkai Wang, Wenxi Jiang, Yongliang Zhong, Jie Du, Yuan Wang   +13 more
wiley   +1 more source

Klf4 Alleviates Lipopolysaccharide-Induced Inflammation by Inducing Expression of MCP-1 Induced Protein 1 to Deubiquitinate TRAF6

Cellular Physiology and Biochemistry, 2018
Background/Aims: Inflammation is an essential component of innate immunity against pathogens, but is tightly regulated, such as by Krüppel-like factor 4 (Klf4), to prevent injury.
Zhenzhen Li, Yanhui Jia, Shichao Han, Xingqin Wang, Fu Han, Julei Zhang, Wei Zhang, Hao Guan, Dahai Hu   +8 more
doaj   +1 more source

USP11 degrades KLF4 via its deubiquitinase activity in liver diseases [PDF]

, 2021
Heeyoung Yang, Daeui Park, Jeong-ho Ryu, Tamina Park   +3 more
openalex   +1 more source

PACAP neuropeptide promotes Hepatocellular Protection via CREB-KLF4 dependent autophagy in mouse liver Ischemia Reperfusion Injury. [PDF]

, 2020
Organ ischemia reperfusion injury (IRI), associated with acute hepatocyte death, remains an unresolved problem in clinical orthotopic liver transplantation (OLT).
Busuttil, Ronald W, Gao, Feng, Ji, Haofeng, Kupiec-Weglinski, Jerzy W, Liu, Yuanxing, Shen, Xiu-da, Xue, Zhengze, Zhang, Cheng, Zhang, Yu, Zheng, Shusen   +9 more
core  

Senescent Synovial Intimal Fibroblasts Aggravate Osteoarthritis by Regulating Macrophage Polarization and Chondrocyte Phenotype Through ANGPTL4‐α5β1 Axis

Advanced Science, EarlyView.
Senescent synovial intimal fibroblasts (SIF) are identified as key drivers of osteoarthritis. They promote M1 macrophage polarization and cartilage degeneration via the ANGPTL4–α5β1 axis, regulated by transcription factors EGR1 and ATF3. Pharmacological inhibition of this pathway alleviates disease, revealing SIF senescence as a promising therapeutic ...
Muhai Deng, Yunsheng Jiang, Zhiyu Chen, Kaiquan Chen, Na Cao, Yang Huang, Zhengxue Quan, Cheng Chen   +7 more
wiley   +1 more source

Regulation of the adaptation to ER stress by KLF4 facilitates melanoma cell metastasis via upregulating NUCB2 expression

Journal of Experimental & Clinical Cancer Research, 2018
Background Adaptation to ER stress has been indicated to play an important role in resistance to therapy in human melanoma. However, the relationship between adaptation to ER stress and cell metastasis in human melanoma remains unclear.
Dongmei Zhang, Jingrong Lin, Yulin Chao, Lu Zhang, Lei Jin, Na Li, Ruiping He, Binbin Ma, Wenzhi Zhao, Chuanchun Han   +9 more
doaj   +1 more source

Cigarette Smoke Initiates Oxidative Stress-Induced Cellular Phenotypic Modulation Leading to Cerebral Aneurysm Pathogenesis. [PDF]

, 2018
OBJECTIVE: Cigarette smoke exposure (CSE) is a risk factor for cerebral aneurysm (CA) formation, but the molecular mechanisms are unclear. Although CSE is known to contribute to excess reactive oxygen species generation, the role of oxidative stress on ...
Ali, Muhammad S., Chalouhi, Nohra, Ding, Dale, Dumont, Aaron S., Hare, Joshua M., Hasan, David M., Jabbour, Pascal, Martinez Lege, Alejandra, Owens, Gary K, Pascale, Crissey L., Starke, Robert M., Thompson, John W., Toborek, Michal   +12 more
core   +2 more sources

Microenvironment‐Guided Evolution of ssDNA‐SWCNT Probes for Selective Recognition of Aggressive Prostate Cancer Phenotypes

Advanced Science, EarlyView.
Random ssDNA–SWCNT(single strand DNA‐single walled carbon nanotube) library is functionally screened and evolved using high‐throughput 3D prostate tumor spheroids via iterative positive and negative selection, enabling the identification of NIR‐II fluorescent ssDNA‐SWCNT nanoprobe specific for prostate cancer.
Dakyeon Lee, Seok‐Hyeon Lee, Yunseo Jung, Jeongho Lee, Min‐Seo Choi, SaeOck Oh, Sungjee Kim, Byoung Soo Kim, Sanghwa Jeong   +8 more
wiley   +1 more source