Results 131 to 140 of about 55,031 (288)

Supplementary Methods, Tables 1-3, Figures 1-10 from Prognostic Value and Function of KLF4 in Prostate Cancer: RNAa and Vector-Mediated Overexpression Identify KLF4 as an Inhibitor of Tumor Cell Growth and Migration

, 2023
Ji Wang, Robert F. Place, Vera Huang, Xiaoling Wang, Emily J. Noonan, Clara E. Magyar, Jiaoti Huang, Long‐Cheng Li   +7 more
openalex   +1 more source

Rejuvenation by cell reprogramming: A new horizon in gerontology [PDF]

, 2018
The discovery of animal cloning and subsequent development of cell reprogramming technology were quantum leaps as they led to the achievement of rejuvenation by cell reprogramming and the emerging view that aging is a reversible epigenetic process. Here,
Brown, Oscar Alfredo, Canatelli Mallat, Martina, Chiavellini, Priscila, Goya, Rodolfo Gustavo, Hereñú, Claudia Beatriz, Lehmann, Marianne   +5 more
core   +2 more sources

Linezolid prevents fibroblast activation and ameliorates tissue fibrosis by inhibition of mitochondrial translation

Arthritis &Rheumatology, Accepted Article.
Background Beyond its role as a ribosome‐targeting antibiotic, linezolid was recently shown to modulate immune responses by inhibiting mitochondrial translation. Since mitochondrial dysfunction is implicated in various fibrotic diseases, including systemic sclerosis (SSc), this study aimed to evaluate the antifibrotic potential of linezolid and ...
Xuezhi Hong, Yanhua Xiao, Haodong Qi, Shihao Zhu, Tim Filla, Andrea‐Hermina Györfi, Yi‐Nan Li, Meilin Xu, Langxian Zhi, Thuong Trinh‐Minh, Clara Dees, Georg Schett, Jörg H.W. Distler, Alexandru‐Emil Matei   +13 more
wiley   +1 more source

Evaluating the miR-302b and miR-145 expression in formalin-fixed paraffin-embedded samples of esophageal squamous cell carcinoma [PDF]

, 2015
Background: MicroRNAs are involved in key cellular processes regulating, and their misregulation is linked to cancer. The miR-302-367 cluster is exclusively expressed in embryonic stem and carcinoma cells.
Khajehei, M., Khalili, M., Khavanin, A., Mansour Samaei, N., Mowla, S.J., Nouraei, N., Tabrizi, M., Vasei, M.   +7 more
core  

Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model. [PDF]

, 2016
We aimed to understand the genetic control of cardiac remodeling using an isoproterenol-induced heart failure model in mice, which allowed control of confounding factors in an experimental setting.
Avetisyan, Rozeta, Gong, Ke Wei, Lusis, Aldons J, Rau, Christoph, Ren, Shuxun, Romay, Milagros C, Stolin, Gabriel, Wang, Jessica Jen-Chu, Wang, Yibin   +8 more
core   +3 more sources

Combinatorial expression of glial transcription factors induces Schwann cell‐specific gene expression in mouse embryonic fibroblasts

Developmental Dynamics, EarlyView.
Abstract Background Schwann cells provide peripheral nerve trophic support, myelinate axons, and assist in repair. However, Schwann cell repair capacity is limited by chronic injury, disease, and aging. Schwann cell reprogramming is a cellular conversion strategy that could provide a renewable cell supply to repair injured nerves.
Lauren Belfiore, Anjali Balakrishnan, Yacine Touahri, Dawn Zinyk, Humna Noman, Satoshi Okawa, Jeff Biernaskie, Carol Schuurmans   +7 more
wiley   +1 more source

Acetylation-dependent regulation of essential iPS-inducing factors: a regulatory crossroad for pluripotency and tumorigenesis [PDF]

, 2015
Induced pluripotent stem (iPS) cells can be generated from somatic cells by coexpression of four transcription factors: Sox2, Oct4, Klf4, and c-Myc.
Dai, Xiangpeng, Inuzuka, Hiroyuki, Lau, Alan W, Liu, Pengda, Liu, Yueyong   +4 more
core   +1 more source

Single‐cell sequencing reveals potential novel insights into appendage‐patterning and joint‐development in a spider

Developmental Dynamics, EarlyView.
Abstract Background Jointed appendages represent one of the key innovations of arthropods, and thus understanding the development and evolution of these structures is important for the understanding of the evolutionary success of Arthropoda. In this paper, we analyze a cell cluster that was identified in a previous single‐cell sequencing (SCS ...
Brenda I. Medina‐Jiménez, Graham E. Budd, Ralf Janssen   +2 more
wiley   +1 more source

The Effect of Physalis angulata L. Administration on Gene Expressions Related to Lung Fibrosis Resolution in Mice-Induced Bleomycin

Journal of Experimental Pharmacology
Ummul Khair Imaduddin,1 Afiat Berbudi,2,* Enny Rohmawaty3,* 1Graduate School of Master Program in Anti Aging and Aesthetic Medicine, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia; 2Parasitology Division, Department ...
Imaduddin UK, Berbudi A, Rohmawaty E
doaj  

Data from Inactivation of the p53–KLF4–CEBPA Axis in Acute Myeloid Leukemia

, 2023
Katja Seipel, Miguel Teixera Marques, Marie-Ange Bozzini, Christina Meinken, Beatrice U. Mueller, Thomas Pabst   +5 more
openalex   +1 more source