Results 141 to 150 of about 55,031 (288)

Deguelin Attenuates Non-Small-Cell Lung Cancer Cell Metastasis by Upregulating PTEN/KLF4/EMT Signaling Pathway [PDF]

, 2022
Guohua Lu, Yinan Yao, Xiaochen Zhang, Dawei Cui, Jianying Zhou   +4 more
openalex   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Additional file 10 of LINC00629 protects osteosarcoma cell from ER stress-induced apoptosis and facilitates tumour progression by elevating KLF4 stability

, 2023
Yuan Wang, Shuo Zheng, Jian Han, Na Li, Renchen Ji, Xiaodong Li, Chuanchun Han, Wenzhi Zhao, Lu Zhang   +8 more
openalex   +1 more source

A global role for zebrafish klf4 in embryonic erythropoiesis

Mechanisms of Development, 2007
There are two waves of erythropoiesis, known as primitive and definitive waves in mammals and lower vertebrates including zebrafish. The founding member of the Kruppel-like factor (KLF) family of CACCC-box binding proteins, EKLF/Klf1, is essential for definitive erythropoiesis in mammals but only plays a minor role in primitive erythropoiesis ...
Gardiner, M. R., Gongora, M. M., Grimmond, S. M., Perkins, A. C.   +3 more
openaire   +3 more sources

Evaluation of commonly used ectoderm markers in iPSC trilineage differentiation. [PDF]

, 2019
Patient-derived induced pluripotent stem cells (iPSCs) have become a promising resource for exploring genetics of complex diseases, discovering new drugs, and advancing regenerative medicine.
Iacovino, Michelina, Iribarren, Carlos, Krauss, Ronald M, Kuang, Yu-Lin, Mattis, Aras N, Medina, Marisa W, Munoz, Antonio, Nalula, Gilbert, Sanchez, Gabriela, Sanghez, Valentina, Santostefano, Katherine E, Terada, Naohiro   +11 more
core  

Reprogramming SREBP1‐dependent lipogenesis and inflammation in high‐risk breast with licochalcone A: A novel path to cancer prevention

International Journal of Cancer, EarlyView.
What's New? Endocrine drugs repurposed from treatment protocols are the primary medications available for breast cancer (BC) prevention in at‐risk women. Adverse effects, however, significantly minimize uptake and prevention impact. Here, the authors investigated licochalcone A (LicA), a non‐endocrine anti‐inflammatory agent with reported hematologic ...
Atieh Hajirahimkhan, Elizabeth T. Bartom, Carolina H. Chung, Xingyu Guo, Kyli Berkley, Seyyedmohsen Hosseinibarkooie, Zahra Assadi, Shao Huan Samuel Weng, Raymond Moellering, Oukseub Lee, Ruohui Chen, Wonhwa Cho, Sriram Chandrasekaran, Susan E. Clare, Seema A. Khan   +14 more
wiley   +1 more source

Sirt6 regulates autophagy in AGE-treated endothelial cells via KLF4

, 2021
Jing Tong, Bing Ji, Yanhua Gao, Hao Lin, Ping Fan, Fei Chen, Xuebo Liu   +6 more
openalex   +1 more source

MicroRNA and transcription factor co-regulatory networks and subtype classification of seminoma and non-seminoma in testicular germ cell tumors [PDF]

, 2020
Recent studies have revealed that feed-forward loops (FFLs) as regulatory motifs have synergistic roles in cellular systems and their disruption may cause diseases including cancer.
Eischen, Christine M., Jia, Peilin, Li, Aimin, Mallik, Saurav, Mitra, Ramkrishna, Qin, Guimin, Zhao, Zhongming   +6 more
core   +2 more sources

Nano‐plastics disrupt systemic metabolism by remodeling the bile acid–microbiota axis and driving hepatic–intestinal dysfunction

iMeta, EarlyView.
The pervasiveness of microplastic pollution poses a growing health risk, yet its long‐term metabolic consequences remain poorly defined. Here, we exposed mice to polyethylene terephthalate nanoparticle (NP) and combined histopathology, biochemistry, metabolomics, and metagenomics to resolve their interactions.
Yi Zhang, Zheng Lin, Runtong Huang, Yang Zhang, Lei Wang, Zan Fu, Chao Wang, Shuai Xiao, Heru Pramono, Kui Xu, Zhimin Xu, Yulong Yin   +11 more
wiley   +1 more source

Overexpression of DNA demethylase ten-eleven translocation 3 mediates high expression of Krüppel-like factor 4 in the skin lesions of patients with psoriasis vulgaris

陆军军医大学学报
Objective To investigate the molecular mechanism of DNA methylation of the abnormally high expression of Krüppel-like factor 4 (KLF4) in psoriasis vulgaris lesions.
ZHANG Shuai, LUO Wen, ZHANG Lian
doaj   +1 more source