Results 11 to 20 of about 55,031 (288)
Molecular basis for modulation of the p53 target selectivity by KLF4 [PDF]
, 2012 The tumour suppressor p53 controls transcription of various genes involved in apoptosis, cell-cycle arrest, DNA repair and metabolism. However, its DNA-recognition specificity is not nearly sufficient to explain binding to specific locations in vivo ...
Brandt, Tobias +4 more
core +14 more sources
Transcriptional Regulation of Adipogenesis by KLF4 [PDF]
Cell Metabolism, 2008 While adipogenesis is known to be controlled by a complex network of transcription factors, less is known about the transcriptional cascade that initiates this process. We report here the characterization of Krüppel-like factor 4 (KLF4) as an essential early regulator of adipogenesis.
Birsoy, Kıvanç +2 more
openaire +2 more sources
MiRrored Regulation of KLF2 and KLF4 [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2012 A healthy organism demands much from its endothelium; constance in homeostatic control of blood fluidity, vascular tone, interaction with circulating blood cells, maintenance of barrier functions, and, when appropriate, creation of new blood vessels. Breakdown in any of these functions, anywhere in the 60,000 miles of vessels in the human body, leads ...
Anne, Hamik, Mukesh K, Jain
openaire +2 more sources
KLF4 Regulates Metabolic Homeostasis in Response to Stress [PDF]
Cells, 2021 Cancerous cells are detrimental to the human body and can be incredibly resilient against treatments because of the complexities of molecular carcinogenic pathways. In particular, cancer cells are able to sustain increased growth under metabolic stress due to phenomena like the Warburg effect.
Andrew Blum +6 more
openaire +3 more sources
KLF4 targets RAB26 and decreases 5-FU resistance through inhibiting autophagy in colon cancer
Cancer Biology & Therapy, 2023 Background Accumulating studies demonstrated that resistance of colon cancer (CC) to 5-fluorouracil (5-FU) contributes to adverse prognosis. We investigated how Kruppel-like factor 4 (KLF4) affected 5-FU resistance and autophagy in CC cells. Methods KLF4
Yu Zheng +8 more
doaj +1 more source
Klf4 protects thymus integrity during late pregnancy
Frontiers in Immunology, 2023 Pregnancy causes abrupt thymic atrophy. This atrophy is characterized by a severe decrease in the number of all thymocyte subsets and qualitative (but not quantitative) changes in thymic epithelial cells (TECs). Pregnancy-related thymic involution is triggered by progesterone-induced functional changes affecting mainly cortical TECs (cTECs). Remarkably,
Lucyle Depoërs +9 more
openaire +3 more sources
Open Life Sciences, 2020 Accumulating evidence suggests that dysregulation of long non-coding RNAs is closely associated with various human diseases, including Parkinson’s disease (PD). However, the role of nuclear-enriched abundant transcript 1 (NEAT1) in the PD process remains
Liu Jiyao +6 more
doaj +1 more source
Food & Nutrition Research, 2020 Background: Anthocyanins (ACNs) are capable of suppressing breast cancer growth; however, investigation on the effect and mechanism of ACNs on epithelial-to-mesenchymal transition (EMT), and cell migration and invasion in breast cancer cells is limited ...
Dahu Chen +6 more
doaj +1 more source
Expression of Kruppel-like factor KLF4 in mouse hair follicle stem cells contributes to cutaneous wound healing. [PDF]
PLoS ONE, 2012 Kruppel-like factor KLF4 is a transcription factor critical for the establishment of the barrier function of the skin. Its function in stem cell biology has been recently recognized. Previous studies have revealed that hair follicle stem cells contribute
Juan Li +7 more
doaj +1 more source
Phosphoproteomics identifies a bimodal EPHA2 receptor switch that promotes embryonic stem cell differentiation [PDF]
, 2020 Embryonic Stem Cell (ESC) differentiation requires complex cell signalling network dynamics, although the key molecular events remain poorly understood.
Budzyk, Manon +10 more
core +2 more sources