Results 91 to 100 of about 22,228 (254)

Centrally circulating α-klotho inversely correlates with human obesity and modulates arcuate cell populations in mice

Molecular Metabolism, 2021
Objective: Our laboratory recently identified the centrally circulating α-klotho protein as a novel hypothalamic regulator of food intake and glucose metabolism in mice. The current study aimed to investigate novel molecular effectors of central α-klotho
Taylor Landry, Peixin Li, Daniel Shookster, Zhiying Jiang, Hongli Li, Brenton Thomas Laing, Wyatt Bunner, Theodore Langton, Qingchun Tong, Hu Huang   +9 more
doaj  

Plasma S-Klotho level affects the risk of hyperuricemia in the middle-aged and elderly people

European Journal of Medical Research, 2022
Background Soluble Klotho (S-Klotho) is an anti-aging protein mainly secreted by the kidneys. Hyperuricemia is prevalent among middle-aged and elderly individuals, which affects the development of various chronic diseases.
Haitao Xie, Ning Li, Guowei Zhou, Qian Liu, Haiyan Wang, Jie Han, Le Shen, Peng Yu, Jiandong Chen, Xiaohu Chen   +9 more
doaj   +1 more source

Spectroscopic survey of M--type asteroids [PDF]

, 2010
M-type asteroids, as defined in the Tholen taxonomy (Tholen, 1984), are medium albedo bodies supposed to have a metallic composition and to be the progenitors both of differentiated iron-nickel meteorites and enstatite chondrites.
A. Migliorini, B. E. Clark, E. Dotto, M. A. Barucci, M. Ockert-bell, S. Fornasier, Sonia Fornasier   +6 more
core   +1 more source

Klotho exerts protection in chronic kidney disease associated with regulating inflammatory response and lipid metabolism

Cell & Bioscience
Background The anti-aging protein Klotho plays a protective role in kidney disease, but its potential as a biomarker for chronic kidney disease (CKD) is controversial.
Junhui Liu, Huaicheng Wang, Qinyu Liu, Shushu Long, Yanfang Wu, Nengying Wang, Wei Lin, Gang Chen, Miao Lin, Junping Wen   +9 more
semanticscholar   +1 more source

Associations Between Serum Soluble α-Klotho and the Prevalence of Specific Cardiovascular Disease

Frontiers in Cardiovascular Medicine, 2022
Objective Accumulating experimental evidence has identified the beneficial effects of the anti-aging protein, serum soluble α-Klotho, on longevity, and the cardiovascular system.
Junpeng Xu, Rui-Xiang Zeng, Mülder He, Shan-Shan Lin, Liheng Guo, Minzhou Zhang   +5 more
semanticscholar   +1 more source

Association between serum cotinine and α-Klotho levels among adults: Findings from the National Health and Nutrition Examination Survey 2007–2016

Tobacco Induced Diseases, 2022
Introduction Serum cotinine is a sensitive and specific marker of tobacco smoke exposure. α-Klotho is an anti-ageing molecule, which plays an important role in several diseases.
Yu Yao, Ying Long, Fa-Wang Du, Yong Zhao, Xiao-Bin Luo   +4 more
doaj   +1 more source

Relationships of serum FGF23 and α-klotho with atherosclerosis in patients with type 2 diabetes mellitus

Cardiovascular Diabetology
Background Compelling evidence suggests that calcium/phosphorus homeostasis-related parameters may be linked to diabetes mellitus and cardiovascular events.
Jiao Bi, Mei Zheng, Ke Li, Siwei Sun, Zihang Zhang, Nana Yan, Xueping Li   +6 more
semanticscholar   +1 more source

Association between serum klotho levels and cardiovascular disease risk factors in older adults

BMC Cardiovascular Disorders, 2022
Background Klotho deficiency is a significant predictor of cardiovascular disease (CVD)-related mortality and morbidity. However, research assessing the association between klotho and individual risk factors of CVD is limited. This study aimed to explore
Jaeho Lee, Donghoon Kim, Hyo-jung Lee, Ju-Young Choi, J. Min, Kyoung-bok Min   +5 more
semanticscholar   +1 more source

Skeletal muscle as a regulator of the longevity protein, Klotho [PDF]

, 2014
Klotho is a powerful longevity protein that has been linked to the prevention of muscle atrophy, osteopenia, and cardiovascular disease. Similar anti-aging effects have also been ascribed to exercise and physical activity.
Ambrosio, F, Avin, KG, Coen, PM, Dubé, JJ, Goodpaster, BH, Huang, W, O'Doherty, RM, Sowa, GA, Stolz, DB   +8 more
core   +1 more source

Klotho protein in neurodegenerative disorders [PDF]

Neurological Sciences, 2018
The Klotho protein is a recently discovered protein and its overexpression is associated with life extension. Klotho deficiency or silencing of the Klotho gene in mice leads to an accelerated aging and short life, whereas overexpression of Klotho in mice extends lifespan.
Magdalena Torbus-Paluszczak, Wojciech Bartman, Monika Adamczyk-Sowa   +2 more
openaire   +3 more sources