Results 91 to 100 of about 33,787 (326)

Klotho to Treat Kidney Fibrosis [PDF]

Journal of the American Society of Nephrology, 2013
Sixteen years ago, defective expression of the murine klotho gene was found to result in a syndrome resembling human aging.[1][1] Tubular kidney cells were the main sites of Klotho expression.
Maria D, Sanchez-Niño, Ana B, Sanz, Alberto, Ortiz   +2 more
openaire   +2 more sources

Olink Proteomics Analysis Reveals Heterogeneous Responses to FcRn Blockade in Anti‐AChR Antibody‐Positive Myasthenia Gravis: FGF‐19 as a Novel Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo, Deyou Peng, Zhouao Zhang, Mingjin Yang, Xinyan Guo, Tianyu Ma, Xiaoyu Huang, Mingming Xu, Linlin Fu, Yong Zhang   +9 more
wiley   +1 more source

Characteristics of urinary and serum soluble Klotho protein in patients with different degrees of chronic kidney disease

BMC Nephrology, 2012
Background Klotho is a single-pass transmembrane protein, which appears to be implicated in aging. The purpose of the present study was to characterize the relationship between the soluble Klotho level and renal function in patients with various degrees ...
Akimoto Tetsu, Yoshizawa Hiromichi, Watanabe Yuko, Numata Akihiko, Yamazaki Tomoyuki, Takeshima Eri, Iwazu Kana, Komada Takanori, Otani Naoko, Morishita Yoshiyuki, Ito Chiharu, Shiizaki Kazuhiro, Ando Yasuhiro, Muto Shigeaki, Kuro-o Makoto, Kusano Eiji   +15 more
doaj   +1 more source

Serum α-Klotho associated with oral health among a nationally representative sample of US adults

Frontiers in Endocrinology, 2022
BackgroundLow klotho is associated with aging-related traits. However, no study has assessed the association between klotho and oral health in a large sample of population.
Guo-Qiang Chen, Guo-Qiang Chen, Yao Duan, Jin-Feng Wang, Ying Lian, Xiu-Li Yin   +5 more
doaj   +1 more source

Klotho exerts protection in chronic kidney disease associated with regulating inflammatory response and lipid metabolism

Cell & Bioscience
Background The anti-aging protein Klotho plays a protective role in kidney disease, but its potential as a biomarker for chronic kidney disease (CKD) is controversial.
Junhui Liu, Huaicheng Wang, Qinyu Liu, Shushu Long, Yanfang Wu, Nengying Wang, Wei Lin, Gang Chen, Miao Lin, Junping Wen   +9 more
semanticscholar   +1 more source

Klotho, Aging, and the Failing Kidney

Frontiers in Endocrinology, 2020
Klotho has been recognized as a gene involved in the aging process in mammals for over 30 years, where it regulates phosphate homeostasis and the activity of members of the fibroblast growth factor (FGF) family.
Sarah J Buchanan, E. Combet, P. Stenvinkel, P. Shiels   +3 more
semanticscholar   +1 more source

Novel functions of circulating Klotho [PDF]

Bone, 2017
A significant portion of the key biological functions of αKlotho (αKL) and its cognate ligand Fibroblast growth factor-23 (FGF23) have been revealed through the study of rare diseases of mineral metabolism. These findings have far reaching implications for common disorders such as chronic kidney disease-mineral bone disorder (CKD-MBD).
Hum, Julia M., O’Bryan, Linda, Smith, Rosamund C., White, Kenneth E.   +3 more
openaire   +2 more sources

A Simplified Three‐Tailed N‐Alkyl Phosphoramidate Lipid Platform Enables Inguinal Adipose‐Accumulated mRNA Delivery for Anti‐Obesity Therapy

Advanced Science, EarlyView.
This study develops an mRNA therapy encoding a long‐acting GLP‐1/FGF21 fusion protein. A three‐tailed ionizable lipid engineered three‐component lipid nanoparticle delivers the mRNA to inguinal adipose tissue. In obese mice, this targeted, dual‐hormone treatment potently reduces body weight, fat mass, presenting a localized strategy for metabolic ...
Bin Ma, Yunxuan Liu, Huijuan Zhang, Yian Fang, Yizhe Xue, Junsheng Xue, Ziqiong Jiang, Tianyan Zhou, Yanyun Hao, Fei Xie, Lei Miao   +10 more
wiley   +1 more source

Inflammation and premature aging in advanced chronic kidney disease [PDF]

, 2017
Systemic inflammation in end-stage renal disease (ESRD) is an established risk factor for mortality and a catalyst for other complications which are related to a premature aging phenotype, including muscle wasting, vascular calcification and other forms ...
Casper G. Schalkwijk, Frank M. van der Sande, Jeroen P. Kooman, Kaysen GA, Len A. Usvyat, Marijke J. Dekker, Paul G. Shiels, Peter Kotanko, Peter Stenvinkel, Witko-Sarsat V   +9 more
core   +1 more source

Relationships of serum FGF23 and α-klotho with atherosclerosis in patients with type 2 diabetes mellitus

Cardiovascular Diabetology
Compelling evidence suggests that calcium/phosphorus homeostasis-related parameters may be linked to diabetes mellitus and cardiovascular events. However, few studies have investigated the association of fibroblast growth factor 23 (FGF23), α-klotho and ...
Jiao Bi, Mei Zheng, Ke Li, Siwei Sun, Zihang Zhang, Nana Yan, Xueping Li   +6 more
semanticscholar   +1 more source