Results 121 to 130 of about 33,787 (326)

Endometrial Stromal Cell Senescence: A Non‐Negligible Factor in Recurrent Pregnancy Loss

iMetaMed, EarlyView.
As populations age, links between female reproductive aging and infertility are increasingly evident. Cellular senescence, characterized by near‐irreversible cell‐cycle arrest and accumulation of damage, can impair tissue function. In the endometrium, aberrant senescence of endometrial stromal cells (EnSCs) may compromise receptivity, hinder embryo ...
Shuang Wu, Cenlan Bu, Qinzheng Xu, Xi Cheng, Junrong Zhang, Jinling Chen, Yun‐Zhao Xu   +6 more
wiley   +1 more source

A Controlled Increase in Dietary Phosphate Elevates BP in Healthy Human Subjects. [PDF]

, 2018
Background Despite epidemiologic evidence for increased cardiovascular morbidity and mortality associated with both high dietary and serum phosphate in humans with normal renal function, no controlled phosphate intervention studies of systemic ...
Bestmann, Lukas, Hulter, Henry N, Krapf, Reto, Mohammad, Jaber, Scanni, Roberto   +4 more
core  

Klotho is highly expressed in the chief sites of regulated potassium secretion, and it is stimulated by potassium intake

Scientific Reports
Klotho regulates many pathways in the aging process, but it remains unclear how it is physiologically regulated. Because Klotho is synthesized, cleaved, and released from the kidney; activates the chief urinary K+ secretion channel (ROMK) and stimulates ...
Hyun Jun Jung, Truyen D. Pham, Xiao-Tong Su, Teodora Veronica Grigore, Joost G. Hoenderop, Hannes Olauson, Susan M. Wall, David H. Ellison, Paul A. Welling, Lama Al-Qusairi   +9 more
doaj   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Spectroscopic survey of M--type asteroids [PDF]

, 2010
M-type asteroids, as defined in the Tholen taxonomy (Tholen, 1984), are medium albedo bodies supposed to have a metallic composition and to be the progenitors both of differentiated iron-nickel meteorites and enstatite chondrites.
A. Migliorini, B. E. Clark, E. Dotto, M. A. Barucci, M. Ockert-bell, S. Fornasier, Sonia Fornasier   +6 more
core   +1 more source

Reduced Circulating α‐Klotho Levels Are Associated With Elevated Mortality and Arterial Calcifications of Aorta and Iliac Arteries

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background α‐Klotho is a multifunctional protein implicated in vascular aging. Declining Klotho levels are associated with arterial stiffness, endothelial dysfunction, and vascular calcification.
Elias Hellou, Parvin Kalhor, Ali Babaie, Nadia Akhiyat, Negin Mahmoudi Hamidabad, Valentina Nardi, Matteo Manzato, Kai Nogami, Elizabeth Copley, Lilach O Lerman, Amir Lerman   +10 more
doaj   +1 more source

Adherence to Mediterranean Diet and Soluble Klotho Level: The Value of Food Synergy in Aging [PDF]

, 2022
Shou‐En Wu, Ying-Jen Chen, Wei‐Liang Chen   +2 more
openalex   +1 more source

Emerging Therapeutic Strategies in Anti‐Aging Medicine: A Comprehensive Review

Medicine Bulletin, EarlyView.
ABSTRACT Aging is orchestrated by interconnected hallmarks such as genomic instability, mitochondrial dysfunction, cellular senescence, and disrupted intercellular communication, which collectively drive chronic disease progression. Recent advances have expanded therapeutic opportunities to include pharmacological agents, gene and epigenome editing ...
Yundong Peng, Rui Li, Huan Li, Jun Zhou, Xuanshi Liu, Guilherme Valente, Tatiana de Campos Melo, Sifan Chen, Lei Gu   +8 more
wiley   +1 more source

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source

Efficacy and safety of SGLT2 inhibitor on insulin resistance and hyperglycemia in Werner syndrome—A case report

Journal of Diabetes Investigation, EarlyView.
Dapagliflozin improved glycemic control and insulin resistance while preserving skeletal muscle mass, body weight, and renal function over 2 years in a patient with Werner syndrome. These findings suggest that SGLT2 inhibitors may be used safely with beneficial effects in patients with Werner syndrome.
Takashi Yagi, Daisuke Aotani, Chie Hasegawa, Yuki Shimizu, Hiroyuki Koyama, Yoshiro Maezawa, Koutaro Yokote, Tomohiro Tanaka   +7 more
wiley   +1 more source