Results 11 to 20 of about 14,696 (214)

Klotho inhibits growth and promotes apoptosis in human lung cancer cell line A549 [PDF]

Journal of Experimental & Clinical Cancer Research, 2010
Background Klotho, as a new anti-aging gene, can shed into circulation and act as a multi-functional humoral factor that influences multiple biological processes.
Zhao Weihong, Wang Xueli, Chen Bo, Wu Jianqing   +3 more
doaj   +2 more sources

Klotho and aging [PDF]

Biochimica et Biophysica Acta (BBA) - General Subjects, 2009
The klotho gene encodes a single-pass transmembrane protein that forms a complex with multiple fibroblast growth factor (FGF) receptors and functions as an obligatory co-receptor for FGF23, a bone-derived hormone that induces negative phosphate balance.
Makoto Kuro‐o
openaire   +4 more sources

Sex differences in the association between serum α-Klotho levels and hyperlipidemia: a cross-sectional study from NHANES 2013–2016 [PDF]

Scientific Reports
This study assessed the association between serum α-Klotho levels and hyperlipidemia. The aim was to ascertain the potential of serum α-Klotho levels as a predictive biomarker for hyperlipidemia.
Yu Han, Chao Liu, Ying Nie, Xijuan Jiang, Na An, Yabin Qin, Yinghua Ma, Zhihua An, Yile Zhao   +8 more
doaj   +2 more sources

Pathobiology of the Klotho Antiaging Protein and Therapeutic Considerations

Frontiers in Aging, 2022
The α-Klotho protein (henceforth denoted Klotho) has antiaging properties, as first observed in mice homozygous for a hypomorphic Klotho gene (kl/kl). These mice have a shortened lifespan, stunted growth, renal disease, hyperphosphatemia, hypercalcemia ...
Gérald J. Prud’homme, Gérald J. Prud’homme, Mervé Kurt, Qinghua Wang, Qinghua Wang   +4 more
doaj   +1 more source

Reduced Plasma Levels of α-Klotho and Their Correlation With Klotho Polymorphisms in Elderly Patients With Major Depressive Disorders

Frontiers in Psychiatry, 2021
Background: Recent literature suggests that α-Klotho, a widely recognized anti-aging protein, is involved in longevity as well as in many diseases, including Alzheimer's disease, and depression.
Xiang Gao, Zuoli Sun, Guangwei Ma, Yuhong Li, Min Liu, Guofu Zhang, Hong Xu, Yane Gao, Jixuan Zhou, Qi Deng, Rena Li, Rena Li   +11 more
doaj   +1 more source

Retinoic acid induces hyaluronic acid production through the klotho-mediated EGFR signaling pathway in human epidermal keratinocytes [PDF]

Archives of Biological Sciences, 2022
All-trans retinoic acid (RA) is an effective anti-aging chemical substance widely used in skin-care products. RA compromises epidermal differentiation and induces keratinocyte proliferation, causing hyaluronic acid production through mechanisms that are ...
Choi Hyangtae, Lee Yonghee, Park Won-seok, Kim Beom Joon, Lee Chang Seok   +4 more
doaj   +1 more source

Klotho endows hepatoma cells with resistance to anoikis via VEGFR2/PAK1 activation in hepatocellular carcinoma. [PDF]

PLoS ONE, 2013
Klotho was originally characterized as an aging suppressor gene that predisposed Klotho-deficient mice to premature aging-like syndrome. Although Klotho was recently reported to exhibit tumor suppressive properties during various malignant ...
Lin Chen, Haiou Liu, Jing Liu, Yu Zhu, Le Xu, Hongyong He, Heng Zhang, Shanshan Wang, Qian Wu, Weisi Liu, Yidong Liu, Deng Pan, Shifang Ren, Jiejie Xu, Jianxin Gu   +14 more
doaj   +1 more source

Protective effects of klotho on palmitate-induced podocyte injury in diabetic nephropathy.

PLoS ONE, 2021
The anti-aging gene, klotho, has been identified as a multi-functional humoral factor and is implicated in multiple biological processes. However, the effects of klotho on podocyte injury in diabetic nephropathy are poorly understood.
Jeong Suk Kang, Seung Seob Son, Ji-Hye Lee, Seong Woo Lee, Ah Reum Jeong, Eun Soo Lee, Seung-Kuy Cha, Choon Hee Chung, Eun Young Lee   +8 more
doaj   +1 more source

Analysis of Immune Responses in Acinetobacter baumannii-Infected Klotho Knockout Mice: A Mouse Model of Acinetobacter baumannii Infection in Aged Hosts

Frontiers in Immunology, 2020
Acinetobacter baumannii is an important opportunistic pathogen that primarily afflicts elderly people. To clarify the pathogenicity of A. baumannii in the elderly, we investigated immune responses to A.
Yoshinori Sato, Shigeru Tansho-Nagakawa, Tsuneyuki Ubagai, Yasuo Ono   +3 more
doaj   +1 more source

Klotho supplementation reverses renal dysfunction and interstitial fibrosis in remnant kidney.

Kidney & Blood Pressure Research, 2023
Introduction: While recent investigations show that klotho exerts reno-protective actions, it has not been fully addressed whether klotho protein supplementation reverses renal damage.
Tsuneo Takenaka, Arif Hasan, Takeshi Marumo, Tsutomu Inoue, Takashi Miyazaki, Hiromichi Suzuki, Yoshifumi Kurosaki, Naohito Ishii, Akira Nishiyama, Matsuhiko Hayashi   +9 more
doaj   +1 more source