Results 11 to 20 of about 33,787 (326)

Interactions of sclerostin with FGF23, soluble klotho and vitamin D in renal transplantation [PDF]

, 2017
Relationships of Sclerostin, a bone anti-anabolic protein, with biomarkers of mineral bone disorders in chronic kidney disease are still unsettled, in particular in kidney transplant (KTR).
Farcomeni, Alessio, Fassino, Valeria, Leonangeli, Cristiana, Mazzaferro, Sandro, Muci, MARIA LUISA, Pasquali, Marzia, Rotondi, Silverio, Tartaglione, Lida   +7 more
core   +9 more sources

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source

Klotho endows hepatoma cells with resistance to anoikis via VEGFR2/PAK1 activation in hepatocellular carcinoma. [PDF]

PLoS ONE, 2013
Klotho was originally characterized as an aging suppressor gene that predisposed Klotho-deficient mice to premature aging-like syndrome. Although Klotho was recently reported to exhibit tumor suppressive properties during various malignant ...
Lin Chen, Haiou Liu, Jing Liu, Yu Zhu, Le Xu, Hongyong He, Heng Zhang, Shanshan Wang, Qian Wu, Weisi Liu, Yidong Liu, Deng Pan, Shifang Ren, Jiejie Xu, Jianxin Gu   +14 more
doaj   +1 more source

Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice

Nature Aging, 2023
Platelet factors regulate wound healing and can signal from the blood to the brain1,2. However, whether platelet factors modulate cognition, a highly valued and central manifestation of brain function, is unknown.
Cana Park, Oliver Hahn, Shweta Gupta, Arturo J. Moreno, Francesca Marino, Blen Kedir, Dan Wang, Saul A. Villeda, T. Wyss-Coray, D. Dubal   +9 more
semanticscholar   +1 more source

The Role and Molecules Mechanism of Klotho in Renal Injury in Salt-sensitive Hypertension [PDF]

Zhongguo quanke yixue, 2023
Background Klotho is closely related to the occurrence and development of kidney disease. Salt-sensitive hypertension (SSH) is often accompanied by kidney disease.
ZHAO Wei, TANG Rongjie, YANG Shanshan, YANG Fang, SUN Feng, LIAN Qiufang
doaj   +1 more source

Age-related matrix stiffening epigenetically regulates α-Klotho expression and compromises chondrocyte integrity

Nature Communications, 2023
Extracellular matrix stiffening is a quintessential feature of cartilage aging, a leading cause of knee osteoarthritis. Yet, the downstream molecular and cellular consequences of age-related biophysical alterations are poorly understood.
H. Iijima, G. Gilmer, Kai Wang, A. Bean, Yuchen He, Hang Lin, W. Tang, Daniel Lamont, Chia Tai, A. Ito, Jeff Jones, C. Evans, F. Ambrosio   +12 more
semanticscholar   +1 more source

Klotho pathways, myelination disorders, neurodegenerative diseases, and epigenetic drugs [PDF]

, 2020
In this review we outline a rationale for identifying neuroprotectants aimed at inducing endogenous Klotho activity and expression, which is epigenetic action, by definition. Such an approach should promote remyelination and/or stimulate myelin repair by
Chen, Xiaohong, Faller, Douglas V., Glavas, Ioannis P., Harpp, David N., Kanara, Iphigenia, Kodukula, Krishna, Mavrakis, Anastasios N., Moos, Walter H., Pernokas, Julie, Pernokas, Mark, Pinkert, Carl A., Powers, Whitney R., Sampani, Konstantina, Steliou, Kosta, Vavvas, Demetrios G., Zamboni, Robert J.   +15 more
core   +1 more source

Longevity factor klotho enhances cognition in aged nonhuman primates

Nature Aging, 2023
Cognitive dysfunction in aging is a major biomedical challenge. Whether treatment with klotho, a longevity factor, could enhance cognition in human-relevant models such as in nonhuman primates is unknown and represents a major knowledge gap in the path ...
S. Castner, Shweta Gupta, Dan Wang, Arturo J. Moreno, Cana Park, Chen Chen, Yan Poon, Aaron Groen, Kenneth Greenberg, Nathaniel David, Tom Boone, M. Baxter, Graham V. Williams, D. Dubal   +13 more
semanticscholar   +1 more source

Analysis of Immune Responses in Acinetobacter baumannii-Infected Klotho Knockout Mice: A Mouse Model of Acinetobacter baumannii Infection in Aged Hosts

Frontiers in Immunology, 2020
Acinetobacter baumannii is an important opportunistic pathogen that primarily afflicts elderly people. To clarify the pathogenicity of A. baumannii in the elderly, we investigated immune responses to A.
Yoshinori Sato, Shigeru Tansho-Nagakawa, Tsuneyuki Ubagai, Yasuo Ono   +3 more
doaj   +1 more source

Protective effects of klotho on palmitate-induced podocyte injury in diabetic nephropathy.

PLoS ONE, 2021
The anti-aging gene, klotho, has been identified as a multi-functional humoral factor and is implicated in multiple biological processes. However, the effects of klotho on podocyte injury in diabetic nephropathy are poorly understood.
Jeong Suk Kang, Seung Seob Son, Ji-Hye Lee, Seong Woo Lee, Ah Reum Jeong, Eun Soo Lee, Seung-Kuy Cha, Choon Hee Chung, Eun Young Lee   +8 more
doaj   +1 more source