Results 51 to 60 of about 33,787 (326)
Serum Klotho (but not haplotypes) associate with the post-myocardial infarction status of older adults [PDF]
, 2016 The number of deaths from vascular diseases is incredibly high worldwide, and reliable markers for major events are still needed. The current cross-sectional study investigated the association of Klotho haplotypes and Klotho serum levels with classic ...
Almeida, Bruno Ratier S. +10 more
core +7 more sources
Klotho increases antioxidant defenses in astrocytes and ubiquitin–proteasome activity in neurons
Scientific Reports, 2023 Klotho is an antiaging protein, and its levels decline with age and chronic stress. The exogenous administration of Klotho can enhance cognitive performance in mice and negatively modulate the Insulin/IGF1/PI3K/AKT pathway in terms of metabolism.
A. Orellana +5 more
semanticscholar +1 more source
Kidney International, 2011 Klotho is a putative aging suppressor gene encoding a single-pass transmembrane co-receptor that makes the fibroblast growth factor (FGF) receptor specific for FGF-23. In addition to multiple endocrine organs, Klotho is expressed in kidney distal convoluted tubules and parathyroid cells, mediating the role of FGF-23 in bone-kidney-parathyroid control ...
openaire +3 more sources
microRNA-200c regulates KLOTHO expression in human kidney cells under oxidative stress.
PLoS ONE, 2019 KLOTHO deficiency is associated with the progression of kidney dysfunction, whereas its overexpression exerts renoprotective effects. Oxidative stress suppresses KLOTHO expression in renal epithelial cells but upregulates microRNA-200c (miR-200c) in ...
Kenichi Morii +8 more
doaj +1 more source
The Organ Handling of Soluble Klotho in Humans
Kidney & Blood Pressure Research, 2019 Background: Chronic kidney disease (CKD) reduces both Klotho expression and its shedding into circulation, an effect that accelerates progression and cardiovascular complications.
Daniela Picciotto +10 more
doaj +1 more source
Scientific Reports, 2023 Ischemia/reperfusion injury (IRI) of the heart involves the activation of oxidative and proapoptotic pathways. Simultaneously Klotho protein presents anti-aging, antiapoptotic and antioxidative properties.
A. Olejnik +3 more
semanticscholar +1 more source
Growth hormone and Klotho [PDF]
Journal of Endocrinology, 2013 Acromegaly is characterized by excessively high GH and IGF1 levels. Recent data suggest that soluble Klotho (sKlotho) is also elevated in patients with active acromegaly. sKlotho decreases towards normal following removal of the GH-producing pituitary adenoma. TheKlothogene was identified in mice following its accidental disruption by ectopic DNA.
Schmid, Christoph +4 more
openaire +2 more sources
The effects of graded levels of calorie restriction : II. Impact of short term calorie and protein restriction on circulating hormone levels, glucose homeostasis and oxidative stress in male C57BL/6 mice [PDF]
, 2015 This work was supported by BBSRC BB009953/1 awarded to JRS and SEM. PK and CD were funded by the Erasmus exchange programme. JRS, SEM, DD, CG, LC, JJDH, YW, DELP, DL and AD are members of the BBSRC China Partnership Award, BB/J020028/1.Peer ...
Chen, Luonan +12 more
core +5 more sources
International Journal of Cell Biology, 2020 Antiaging protein Klotho exhibits impressive properties of anti-inflammation, however is declined early after intervertebral disc injury, making Klotho restoration an attractive strategy of treating intervertebral disc inflammatory disorders.
Fangfang Bi +4 more
doaj +1 more source
Antioxidants, 2023 Initially discovered by Makuto Kuro-o in 1997, Klotho is a putative aging-suppressor gene when overexpressed and accelerates aging when deleted in mice. Previously, we showed that α-Klotho regulates retinal pigment epithelium (RPE) functions and protects
Shuyan Zhou +6 more
semanticscholar +1 more source