Results 51 to 60 of about 22,228 (254)
American Journal of Nephrology, 2023 Introduction: Kidney stones (KSs) are associated with hematuria and renal failure and pose a significant clinical and public health concern. Diabetes is associated with a higher risk of KSs.
Yuxiuzi Xiao, Zuo Xiao
semanticscholar +1 more source
The relevance of α-KLOTHO to the central nervous system: Some key questions [PDF]
, 2017 α-Klotho is well described as an anti-aging protein, with critical roles in kidney function as a transmembrane co-receptor for FGF23, and as a soluble factor in serum.
Berwick, Daniel Charles +4 more
core +1 more source
Klotho is upregulated in human cardiomyopathy independently of circulating Klotho levels [PDF]
Scientific Reports, 2018 AbstractKlotho is an antiaging protein which exerts known cardioprotection. In kidney, trans-membrane Klotho acts as essential co-receptor of fibroblast growth factor 23 (FGF23). In the heart, soluble Klotho (sKlotho) protects from systolic dysfunction independently of FGF23.
G. Poelzl +9 more
openaire +2 more sources
Clinical Kidney Journal, 2023 Klotho, a multifunctional protein, acts as a co-receptor in fibroblast growth factor 23 and exerts its impact through various molecular pathways, including Wnt, hypoxia-inducible factor and insulin-like growth factor 1 pathways.
M. Kanbay +7 more
semanticscholar +1 more source
Klotho mice: a novel wound model of aged skin. [PDF]
, 2014 BackgroundAs the elderly population continues to expand, it becomes increasingly important to develop treatments to improve wound healing in the elderly.
Yamashita, Ken +3 more
core +2 more sources
The emerging role of cellular senescence in renal diseases [PDF]
, 2020 Cellular senescence represents the state of irreversible cell cycle arrest during cell division. Cellular senescence not only plays a role in diverse biological events such as embryogenesis, tissue regeneration and repair, ageing and tumour occurrence ...
Alpini, Gianfranco +12 more
core +1 more source
Current understanding of klotho [PDF]
Ageing Research Reviews, 2009 Klotho is a new anti-aging gene. Genetic mutation of klotho causes multiple premature aging-like phenotypes and strikingly shortens lifespan. Overexpression of the klotho gene in mice suppresses aging and extends lifespan which may involve the mechanism of suppression of insulin signaling and oxidant stress.
Zhongjie Sun, Yuhong Wang
openaire +3 more sources
Scientific Reports, 2021 The Naked Mole Rat (NMR), Heterocephalus glaber, provides an interesting model for studying biomarkers of longevity due to its long lifespan of more than 30 years, almost ten times longer than that of mice and rats.
M. Morevati +10 more
doaj +1 more source
Frontiers in Endocrinology, 2023 Objective The Klotho protein is a well-documented anti-aging protein known for its diverse biological functions. Hyperlipidemia is an established independent risk factor for various chronic diseases.
Shaohua Yan +4 more
semanticscholar +1 more source
Klotho controls the brain-immune system interface in the choroid plexus. [PDF]
, 2018 Located within the brain's ventricles, the choroid plexus produces cerebrospinal fluid and forms an important barrier between the central nervous system and the blood.
Ho, Kaitlyn +7 more
core +1 more source